Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods that detect, utilizing a shape detection neural network, one or more shapes depicted in a digital image. The disclosed systems identify, from the one or more shapes depicted in the digital image, a background region comprising background pixels depicted in the digital image. The disclosed systems determine that the background region depicts solid fill pixels. The disclosed systems determine a prominent color for the solid fill pixels based on determining that the background region depicts solid fill pixels. The disclosed systems generate, from the prominent color, an image layer for the digital image.

Abstract: Digital image text grouping techniques are described. A digital image depicting text is received and a plurality of items of text data are extracted from the digital image. A plurality of text characteristic data is detected, respectively, that is associated with the plurality of items of text data. At least one text group is generated that includes two or more of the plurality of items of text data. The text group is generated by determining similarity of the plurality of items of text data, one to another, based on the plurality of text characteristic data. The at least one text group is presented for display in a user interface.

Abstract: Disclosed herein photopatterned hydrogels, hydrogel-based microfluidic devices, methods of making hydrogel-based microfluidic devices, and methods of using hydrogel-based microfluidic devices.

Abstract: An integrated GHz ultrasonic neuro-cognitive system including a chip-cyborg having a network of biological neurons that forms a biological information processor, which can be controlled by electronics, optics, and GHz ultrasonic beams. In one example, the chip-scale microsystem includes a CMOS chip with RF CMOS and piezoelectric thin film transducers that can generate GHz ultrasonic waves, which can be phased to form narrow beams, achieving significant ultrasonic intensity to affect neurons. With a sufficient number of ultrasonic pixels, the focal point of the beam can be narrow enough to focus effect specific section of a neuron to enhance or decrease synaptic weights owing to ultrasonic radiation forces and acoustic streaming.

Abstract: Disclosed herein are hydrogel structures and methods of making and use thereof. For example, disclosed herein are methods of making a device comprising a hydrogel matrix and a first chamber in the hydrogel matrix, the hydrogel matrix being derived from a prepolymer and the first chamber being perfusable. The methods can, for example, comprise blocking a first portion of a pre-polymerization solution with a first photomask, the pi-polymerization solution comprising the prepolymer, such that the pre-polymerization solution comprises an exposed portion and a first blocked portion. The methods can further comprise irradiating the exposed portion of the pi-polymerization solution and the first photomask with electromagnetic radiation, the first photomask being substantially opaque to the electromagnetic radiation.

Abstract: The present application relates to a silicon nanoprojection device comprising a substrate having a surface and one or more nanoprojection structures having a proximal end attached to said substrate and extending away from the surface of the substrate to a distal end. The one or more nanoprojection structures either have a configuration which tapers narrowingly from the proximal end to the distal end or have an ionic coating. Also disclosed are methods of making and using the silicon nanoprojection device.

Abstract: A gel composition that forms a three dimensional gel microenvironment that is formed of an adhesive protein, a maleimide-functionalized poly alkylene oxide, a linking agent and a nanoparticle, the components forming an interpenetrating network that exhibits improved mechanical and biochemical properties, as well as creates a favorable microenvironment for cellular growth and proliferation. The gel composition also creates a favorable microenvironment for testing various agents on normal or diseased cells, including chemotherapeutic agents on cancer cells or other diseased cells.

Abstract: An integrated GHz ultrasonic neuro-cognitive system including a chip-cyborg having a network of biological neurons that forms a biological information processor, which can be controlled by electronics, optics, and GHz ultrasonic beams. In one example, the chip-scale microsystem includes a CMOS chip with RF CMOS and piezoelectric thin film transducers that can generate GHz ultrasonic waves, which can be phased to form narrow beams, achieving significant ultrasonic intensity to affect neurons. With a sufficient number of ultrasonic pixels, the focal point of the beam can be narrow enough to focus effect specific section of a neuron to enhance or decrease synaptic weights owing to ultrasonic radiation forces and acoustic streaming.

Abstract: The present invention provides for methods of isolating a stem cell or cell derived therefrom from a mixture of cells, for example, a mixture of adherent cells in culture. Cell isolation is achieved by the application of selective detachment forces.

Abstract: The present invention provides for methods of isolating a stem cell or cell derived therefrom from a mixture of cells, for example, a mixture of adherent cells in culture. Cell isolation is achieved by the application of selective detachment forces.

Abstract: A method for image processing performed by a computing device includes: (a) receiving one or more images and preprocessing the one or more images by extracting one or more features from the one or more images; (b) estimating image homographies (and/or fundamental matrices) based on the one or more features extracted from the one or more images; (c) determining particle trajectories based on composition of the image homographies (and/or fundamental matrices), wherein a particle trajectory comprises image pixel points identified in a subset of the one or more images; and (d) determining a joint estimation of camera pose, camera parameters, and a dense depth map using the particle trajectories.

Abstract: Provided are compositions and methods that relate ex vivo organoids that contain B cells and stromal cells in a three dimensional material includes a hydrogel. The hydrogel can be formed without exposure to ultraviolet light from an electronic ultraviolet light source. The hydrogel contains silicate nanoparticles (SiNPs) that are ionically bonded to a polyampholytic gelatin. The three dimensional material can be held at a temperature of at least 37 degrees Celsius and does not liquefy. The organoids exhibit mechanical properties that are similar to certain lymphoid tissues, and can include a germinal center. Methods of making the organoids are included, as are high throughput screening approaches that use the organoids for screening a variety of test agents. The organoids can synthesize a variety of compounds that can be recovered from the organoids or the organoid culture medium.

Abstract: A method for image processing performed by a computing device includes: (a) receiving one or more images and preprocessing the one or more images by extracting one or more features from the one or more images; (b) estimating image homographies (and/or fundamental matrices) based on the one or more features extracted from the one or more images; (c) determining particle trajectories based on composition of the image homographies (and/or fundamental matrices), wherein a particle trajectory comprises image pixel points identified in a subset of the one or more images; and (d) determining a joint estimation of camera pose, camera parameters, and a dense depth map using the particle trajectories.

Abstract: The present invention provides for methods of isolating a stem cell or cell derived therefrom from a mixture of cells, for example, a mixture of adherent cells in culture. Cell isolation is achieved by the application of selective detachment forces.

Abstract: The present invention provides for methods of isolating a stem cell or cell derived therefrom from a mixture of cells, for example, a mixture of adherent cells in culture. Cell isolation is achieved by the application of selective detachment forces.

Abstract: The present invention provides for methods of isolating a stem cell or cell derived therefrom from a mixture of cells, for example, a mixture of adherent cells in culture. Cell isolation is achieved by the application of selective detachment forces.

Abstract: The present invention provides methods of isolating a cancer-associated cell, such as a cancer stem cell or tumor initiating cell or a cell derived therefrom, from a mixture of cells, for example, a mixture of adherent cells in culture. Cell isolation is achieved by the application of selective detachment forces.

Abstract: A gel composition that forms a three dimensional gel microenvironment that is formed of an adhesive protein, a maleimide-functionalized poly alkylene oxide, a linking agent and a nanoparticle, the components forming an interpenetrating network that exhibits improved mechanical and biochemical properties, as well as creates a favorable microenvironment for cellular growth and proliferation. The gel composition also creates a favorable microenvironment for testing various agents on normal or diseased cells, including chemotherapeutic agents on cancer cells or other diseased cells.

Abstract: The present invention provides for methods of isolating a stem cell or cell derived therefrom from a mixture of cells, for example, a mixture of adherent cells in culture. Cell isolation is achieved by the application of selective detachment forces.

Abstract: One embodiment of the current disclosure relates to an immune-modulating composition comprising a hydrogel-forming polymer, an immune-modulating biomolecule operable to recruit or retain an immune cell, and an antigen-related biomolecule. Another embodiment of the current disclosure relates to a method of providing an antigen to an antigen presenting cell in an animal by administering to the animal at an administration site an immune-modulating composition as described above. Next, one forms a hydrogel in-situ from the hydrogel-forming polymer, then recruits at least one antigen presenting cell to the administration site using the immune-modulating biomolecule, and finally inducing phagocytosis of the at least one antigen-related biomolecule by the antigen presenting cell.