Patents by Inventor Anle Yang

Anle Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Plasmin inhibitor, preparation method therefor and application thereof
    Patent number: 12649755
    Abstract: A compound of formula (I) capable of inhibiting plasmin activity, delaying fibrinolysis, and having coagulation and hemostatic activity, pharmaceutically acceptable salts, hydrates, isomers, prodrugs and mixtures thereof, wherein X, and R1 to R5 are as defined in the description.
    Type: Grant
    Filed: December 30, 2021
    Date of Patent: June 9, 2026
    Assignee: SCINNOHUB PHARMACEUTICAL CO., LTD
    Inventors: Anle Yang, Sen Ji, Zhi Wang, Hao Wang, Dewei Zhang, Xiao Wang, Huan Shen, Jie Xiang, Jialing Xian, Yan Wang, Xiao Hu, Xiaodong Zhang, Jun Tang
  • Fluorine-containing heterocyclic derivatives with macrocyclic structure and use thereof
    Patent number: 12428433
    Abstract: Disclosed are a macrocyclic fluorine-containing heterocyclic derivative of formula (I), a preparation method thereof, and a use thereof in treatment of TRK kinase-mediated diseases.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: September 30, 2025
    Assignee: SCINNOHUB PHARMACEUTICAL CO., LTD
    Inventors: Anle Yang, Haoxi Huang, Tonghui Chen, Jie Liang, Dewei Zhang, Jingen Deng, Hongbo Li, Junjie Pu
  • COMPOUND FOR REGULATING AND CONTROLLING 15-PGDH ACTIVITY AND PREPARATION METHOD THEREFOR
    Publication number: 20250154162
    Abstract: The present application relates to a compound represented by formula (I) and used for regulating and controlling the 15-PGDH activity and an application thereof in the pharmaceutical field. The present application further provides a method for preparing the compound of the present application, a composition comprising the compound of the present application, and a pharmaceutical use of the compound in serving as a 15-PGDH inhibitor.
    Type: Application
    Filed: January 20, 2023
    Publication date: May 15, 2025
    Inventors: Anle YANG, Sen JI, Hao WANG, Dewei ZHANG, Xiao WANG, Xinying QIAN, Zhiyong LI, Xiaodong ZHANG, Jun TANG
  • PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Publication number: 20240300986
    Abstract: A compound of formula (I) capable of inhibiting plasmin activity, delaying fibrinolysis, and having coagulation and hemostatic activity, pharmaceutically acceptable salts, hydrates, isomers, prodrugs and mixtures thereof, wherein X, and R1 to R5 are as defined in the description.
    Type: Application
    Filed: December 30, 2021
    Publication date: September 12, 2024
    Inventors: Anle YANG, Sen JI, Zhi WANG, Hao WANG, Dewei ZHANG, Xiao WANG, Huan SHEN, Jie XIANG, Jialing XIAN, Yan WANG, Xiao HU, Xiaodong ZHANG, Jun TANG
  • METHIONINE ADENOSYLTRANSFERASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Publication number: 20240228491
    Abstract: Disclosed are a methionine adenosyltransferase inhibitor represented by formula (I), a preparation method thereof and an application thereof in the pharmaceutical field, wherein R1, R2, R3 and A are as defined in the description and claims.
    Type: Application
    Filed: April 28, 2022
    Publication date: July 11, 2024
    Inventors: Anle YANG, Dewei ZHANG, Lijin DONG, Quanhong HE, Tao YI, Jiang MENG, Lin TIAN, Jie LIANG, Ze FENG, Kai HU, Xiaodong ZHANG, Yi ZHANG, Xi HU, Yanan HOU, Jun TANG
  • PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
    Publication number: 20240124443
    Abstract: The present invention relates to a compound of formula (I) capable of inhibiting plasmin activity and having blood coagulation and hemostasis activity, and a pharmaceutically acceptable salt, hydrate, isomer, prodrug and mixture thereof, wherein R1 to R3 are as defined in the description.
    Type: Application
    Filed: January 28, 2022
    Publication date: April 18, 2024
    Inventors: Anle YANG, Sen JI, Zhi WANG, Hao WANG, Dewei ZHANG, Xiao WANG, Huan SHEN, Jie XIANG, Jialing XIAN, Yan WANG, Xiao HU, Xiaodong ZHANG, Jun TANG
  • FLUORINE-CONTAINING HETEROCYCLIC DERIVATIVES WITH MACROCYCLIC STRUCTURE AND USE THEREOF
    Publication number: 20230044722
    Abstract: Disclosed are a macrocyclic fluorine-containing heterocyclic derivative of formula (I), a preparation method thereof, and a use thereof in treatment of TRK kinase-mediated diseases.
    Type: Application
    Filed: December 11, 2020
    Publication date: February 9, 2023
    Inventors: Anle YANG, Haoxi HUANG, Tonghui CHEN, Jie LIANG, Dewei ZHANG, Jingen DENG, Hongbo LI, Junjie PU
  • Sulfonyl substituted bicyclic compound which acts as ROR inhibitor
    Patent number: 11396503
    Abstract: Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a ROR? inhibitor, said compound has good ROR? inhibitory activity and is expected to be used for treating diseases mediated by a ROR? receptor in mammals.
    Type: Grant
    Filed: September 30, 2018
    Date of Patent: July 26, 2022
    Assignees: Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Nanjing Gear Pharma & Tech Co., Ltd.
    Inventors: Xiaolong Wang, Anle Yang, Hongjian Jiang, Jian Zhou, Lei Chen, Xiaolong Jiang, Ling Yang, Hongjiang Xu, Xiaohan Geng
  • SULFONYL SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR
    Publication number: 20200239454
    Abstract: Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a ROR? inhibitor, said compound has good ROR? inhibitory activity and is expected to be used for treating diseases mediated by a ROR? receptor in mammals.
    Type: Application
    Filed: September 30, 2018
    Publication date: July 30, 2020
    Applicants: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., NANJING GEAR PHARMA & TECH CO., LTD.
    Inventors: Xiaolong WANG, Anle YANG, Hongjian JIANG, Jian ZHOU, Lei CHEN, Xiaolong JIANG, Ling YANG, Hongjiang XU, Xiaohan GENG
  • Pyrrolopyrazoles, potent kinase inhibitors
    Patent number: 8530652
    Abstract: Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: September 10, 2013
    Assignees: Agouron Pharmaceuticals, Inc., Pfizer Inc.
    Inventors: Junhu Zhang, Chuangxing Guo, Djamal Bouzida, Liming Dong, Haitao Li, Joseph Timothy Marakovits, Anle Yang, Yufeng Hong
  • PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS
    Publication number: 20120264751
    Abstract: Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
    Type: Application
    Filed: October 6, 2011
    Publication date: October 18, 2012
    Inventors: Junhu ZHANG, Chuangxing Guo, Djamal Bouzida, Liming Dong, Haitao Li, Joseph Timothy Marakovits, Anle Yang, Yufeng Hong
  • Pyrrolopyrazole, potent kinase inhibitors
    Patent number: 8067591
    Abstract: Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
    Type: Grant
    Filed: December 28, 2005
    Date of Patent: November 29, 2011
    Assignees: Agouron Pharmaceuticals, Inc., Pfizer Inc.
    Inventors: Junhu Zhang, Chuangxing Guo, Djamal Bouzida, Liming Dong, Haitao Li, Joseph Timothy Marakovits, Anle Yang, Yufeng Hong
  • Carbonylamino pyrrolopyrazoles, potent kinase inhibitors
    Patent number: 7884117
    Abstract: Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: February 8, 2011
    Assignee: Pfizer Inc.
    Inventors: Junhun Zhang, Anle Yang, Susan Elizabeth Kephart, Liming Dong, Chuangxing Guo, Yufeng Hong, Mary Catherine Johnson, Indrawan James McAlpine, Jayashree Tikhe, Haitao Li
  • PYRROLOPYRAZOLE, POTENT KINASE INHIBITORS
    Publication number: 20100222342
    Abstract: Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
    Type: Application
    Filed: December 28, 2005
    Publication date: September 2, 2010
    Inventors: Junhu Zhang, Chuangxing Guo, Djamal Bouzida, Liming Dong, Haitao Li, Joseph Timothy Marakovits, Anle Yang, Yufeng Hong
  • CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS
    Publication number: 20090318440
    Abstract: Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
    Type: Application
    Filed: December 12, 2006
    Publication date: December 24, 2009
    Inventors: Junhu Zhang, Anle Yang, Susan Elizabeth Kephart, Liming Dong, Chuangxing Guo, Yufeng Hong, Mary Catherine Johnson, Indrawan James Mc Alpine, Jayashree Tikhe, Haitao Li
  • Inhibitors of the HIV integrase enzyme
    Patent number: 7468375
    Abstract: The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: December 23, 2008
    Assignee: Pfizer Inc.
    Inventors: Klaus Ruprecht Dress, Qiyue Hu, Ted William Johnson, Michael Bruno Plewe, Steven Paul Tanis, Hai Wang, Anle Yang, Chunfeng Yin, Junhu Zhang
  • Inhibitors of the Hiv Integrase Enzyme
    Publication number: 20070232644
    Abstract: The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical compositions comprising compounds of formula (I), and their methods of use in treating HIV-infected mammals.
    Type: Application
    Filed: August 26, 2005
    Publication date: October 4, 2007
    Inventors: Klaus Dress, Jon Kuehler, Michael Plewe, Anle Yang, Junhu Zhang
  • Inhibitors of the HIV integrase enzyme
    Publication number: 20050277662
    Abstract: The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
    Type: Application
    Filed: April 25, 2005
    Publication date: December 15, 2005
    Inventors: Klaus Dress, Qiyue Hu, Ted Johnson, Michael Plewe, Steven Tanis, Hai Wang, Anle Yang, Chunfeng Yin, Junhu Zhang