Abstract: Provided is an oral Pt(IV) anticancer prodrug containing a 3-bromopyruvate as an axial ligand, with a molecular formula of cis,trans,cis-[Pt(1R,2R-diaminocyclohexane)(OH)(3-bromopyruvate)(C2O4)]. It is a prodrug of oxaliplatin and 3-bromopyruvic acid is a small molecular glycolysis inhibitor. The prodrug is able to simultaneously act on DNA replication and glycolytic pathways of cancer cells, giving full play to the advantage of double-acting targets. The oral Pt(IV) anticancer prodrug is synthesized by using oxaliplatin as a starting material, performing axial oxidation with H2O2 and neutralizing the oxidized product with 3-bromopyruvic acid.

Abstract: Provided are a water-soluble Pd(II) complex, a synthesis method thereof and use thereof as a catalytic precursor. The complex has a chemical name, ammonium dinitrooxalato palladium (II), and a molecular formula of (NH4)2[Pd(NO2)2(C2O4)]·nH2O (n is the number of crystal water). The Pd(II) complex is synthesized by using PdCl2 or [Pd(NH3)2Cl2] as a starting material which is firstly converted into [Pd(NH3)4]Cl2 in ammonium hydroxide, followed by a chemical reaction between [Pd(NH3)4]Cl2 and excessive NaNO2 to produce trans-[Pd(NH3)2(NO2)2] via ligand substitution mechanism, and finally dissolving trans-[Pd(NH3)2(NO2)2] in an aqueous solution of oxalic acid leads to the formation of the target product (NH4)2[Pd(NO2)2(C2O4)]·2H2O. The complex does not contain chlorine and other elements that are harmful to a catalyst, is readily soluble in water and has a low thermal decomposition temperature.

Abstract: Defective pixels in a CMOS array give rise to spot noise that diminishes the integrity of the resulting image. Because CMOS arrays and digital logic can be fabricated on the same integrated circuit using the same processing technology and relatively inexpensive and fast circuit can be employed to digitally filter the pixel data stream and to identify pixels having values that do not fall in the range defined by the immediately neighboring pixels and the deviate from the neighboring pixels by more than a threshold amount. Such conditions would indicate that the deviation is caused by a defective pixel rather than by desired image data. The threshold amount can be preprogrammed or can be provided by a user or can be dynamically set using feedback indicating image quality. The filter would also provide a solution for other sensors such as CCD, although a single chip solution would likely not be possible.

Abstract: The pixels of an image sensor array can be readout (84, 85) in m×n blocks (m, n) that are compatible with the operation of a desired image compression algorithm (14), thereby reducing the amount of memory required by the image compression algorithm.

Abstract: Image enhancement is automatically achieved by calibrating the reference voltage and gain of a differential amplifier and the integration interval so as to provide an input to a differential analog to digital converter (ADC) that utilizes the full dynamic range of the ADC. When used with a CMOS array, the imaging logic can be fabricated on a single chip with the array using combinational logic for fast, inexpensive calibration. Another advantageous feature is the ability to expand a desired portion of the luminance spectrum of the image in order to increase the digital resolution of the resulting image for that portion of the spectrum of interest.

Abstract: Defective pixels in a CMOS array give rise to spot noise that diminishes the integrity of the resulting image. Because CMOS arrays and digital logic can be fabricated on the same integrated circuit using the same processing technology and relatively inexpensive and fast circuit can be employed to digitally filter the pixel data stream and to identify pixels having values that do not fall in the range defined by the immediately neighboring pixels and the deviate from the neighboring pixels by more than a threshold amount. Such conditions would indicate that the deviation is caused by a defective pixel rather than by desired image data. The threshold amount can be preprogrammed or can be provided by a user or can be dynamically set using feedback indicating image quality. The filter would also provide a solution for other sensors such as CCD, although a single chip solution would likely not be possible.

Abstract: The invention provides for the filtering of pixel defects from CMOS imagers. The invention comprises scanning each of a plurality of pixels within a block (420), and designating a pixel as a process pixel (430). The process pixel is then compared to adjacent pixels to see if the process pixel value deviates significantly from an adjacent pixel value (450), to determine if error correction is needed.

Abstract: The pixels of an image sensor array can be readout (84, 85) in m×n blocks (m, n) that are compatible with the operation of a desired image compression algorithm (14), thereby reducing the amount of memory required by the image compression algorithm.