Abstract: An aerosolizing delivery device can include a carriage configured to be detachably connected to a mouthpiece and to receive and support an aerosolizable powder-filled cartridges in a desired position relative to the mouthpiece. The carriage can include: a housing defining a reservoir and a carriage outlet, the carriage outlet configured to permit fluid communication between the reservoir and an exterior of the carriage. A surface of the housing can be configured to define a bypass port between the housing and a surface of the mouthpiece when the carriage is assembled with the mouthpiece to form the delivery device.