Abstract: Systems and methods for machine learning architecture for out-of-distribution data detection. The system may include a processor and a memory storing processor-executable instructions that may, when executed, configure the processor to: receive an input data set; generate an out-of-distribution prediction based on the input data set and an auto-encoder, the auto-encoder trained based on a pretext task including a transformation of one or more training data sets for reconstruction, the trained auto-encoder trained for reducing a reconstruction error to encode semantic meaning of the training data sets; and generate a signal for providing an indication of whether the input data set is an out-of-distribution data set.