Abstract: A method for rapid data analysis includes receiving and interpreting a first query operating on a first dataset partitioned into shards by a first field; collecting a first data sample from a first set of data shards; calculating a first result to the first query based on analysis of the first data sample; and partitioning a second dataset into shards by a second field based on the first result.

Abstract: An audio projection device having additional features or elements connected therewith. One or more lights or other illuminating elements may be connected with the audio projection device. The one or more lights or other illuminating elements may be disposed so as to illuminate through a portion of the audio projection device. One or more audible or other moveable elements may be connected or contained within a portion of the audio projection device. The one or more audible or moveable elements may be beads, or other spherical or other shaped components (e.g., rigid components) that are configured to make a sound (e.g., rattle) and/or be visible when they make contact with one another and/or other portions of the audio projection device. The audio projection device may be fully or partially transparent such that the one or more audible or moveable elements are viewable through material(s) of the audio projection device.

Abstract: A low alloy, high performance steel having high impact toughness and high ductility, as well as methods of making and heat treating the alloy, are provided. The alloy steel composition consists essentially of about 0.24% to about 0.32% carbon, about 2.00% to about 3.00% chromium, about 0.50% to about 1.50% molybdenum, about 0.05% to about 0.35% vanadium, about 1.00% manganese or less, about 3.00% nickel or less, about 1.50% silicon or less, with minimal impurities, and balance consisting essentially of iron, wherein % is weight percent based on the entire weight of the alloy steel composition. The impurities may include about 0.20% copper or less, about 0.015% phosphorous or less, about 0.012% sulfur or less, about 0.02% calcium or less, about 0.15% nitrogen or less, and/or about 0.025% aluminum or less. Also disclosed is a hardened and tempered article that has high impact toughness, as well as other favorable physical properties.

Abstract: An audio projection device having additional features or elements connected therewith. One or more lights or other illuminating elements may be connected with the audio projection device. The one or more lights or other illuminating elements may be disposed so as to illuminate through a portion of the audio projection device. One or more audible or other moveable elements may be connected or contained within a portion of the audio projection device. The one or more audible or moveable elements may be beads, or other spherical or other shaped components (e.g., rigid components) that are configured to make a sound (e.g., rattle) and/or be visible when they make contact with one another and/or other portions of the audio projection device. The audio projection device may be fully or partially transparent such that the one or more audible or moveable elements are viewable through material(s) of the audio projection device.

Abstract: A low alloy, high performance steel having high impact toughness and high ductility, as well as methods of making and heat treating the alloy, are provided. The alloy steel composition consists essentially of about 0.24% to about 0.32% carbon, about 2.00% to about 3.00% chromium, about 0.50% to about 1.50% molybdenum, about 0.05% to about 0.35% vanadium, about 1.00% manganese or less, about 3.00% nickel or less, about 1.50% silicon or less, with minimal impurities, and balance consisting essentially of iron, wherein % is weight percent based on the entire weight of the alloy steel composition. The impurities may include about 0.20% copper or less, about 0.015% phosphorous or less, about 0.012% sulfur or less, about 0.02% calcium or less, about 0.15% nitrogen or less, and/or about 0.025% aluminum or less. Also disclosed is a hardened and tempered article that has high impact toughness, as well as other favorable physical properties.

Abstract: A new thiophene substituted antitumor antifolate, N{[5-(2,4-diamino-6-pteridinyl)ethyl]2-theonyl}-L-glutamic acid having the structural formula 1 is provided, as well as methods for its preparation. The new thiophene substituted antifolate 1 is a very potent inhibitor of the enzyme dihydrofolate reductase, undergoes moderate polyglutamylation and is transported to tumor cells more effectively than methotrexate. Compound 1 is an excellent inhibitor of tumor cells growth in culture, the potency being superior to methotrexate against CCRF-CEM human lukemia cells.

Abstract: Three new non-polyglutamatable glutamic acid derivatives in the antifolate series are provided as well as procedures for their preparation. These compounds are: 4-amino-4-deoxy-10-deazapteroyl-.tau.-methyleneglutamic acid (1); 4-amino-4-deoxy-10-ethyl-10-deazapteroyl-.tau.-methylene-glutamic acid (2); and 4-amino-4-deoxy-10-deazapteroyl-3-hydroxyglutamic acid (3). None of the compound undergo polyglutamylation as determined by their inability to serve as substrates for folylpolyglutamate synthetase (FPGS). Compounds 1 and 2 are transported more effectively to tumor cells and they are more powerful in inhibiting the growth of human leukemia cells in culture as compared to the standard anticancer drug methotrexate. All three compounds (1, 2, and 3) inhibit human dihydrofolate reductase to the same extent as methotrexate.