Patents by Inventor Ann C. Griffin

Ann C. Griffin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection and treatment methods for type I diabetes
    Publication number: 20040002113
    Abstract: Proinsulin peptide compounds that modulate an immunological response by T cells of Type I diabetic subjects are disclosed. The proinsulin peptide compounds of the invention are preferably derived from a region of proinsulin that spans the junction between the B chain and C peptide of proinsulin. Pharmaceutical compositions comprising the proinsulin peptide compounds are also disclosed. An immunological response to a proinsulin peptide compound of the invention can be used as an indicator of Type I diabetes in a subject. Accordingly, the invention provides diagnostic assays for Type I diabetes using the proinsulin peptide compounds. Methods for inhibiting the development or progression of Type I diabetes in a subject by administering a proinsulin peptide compound are also disclosed.
    Type: Application
    Filed: December 17, 2002
    Publication date: January 1, 2004
    Applicant: Trustees of Dartmouth College
    Inventors: Ann C. Griffin, William F. Hickey
  • Proinsulin peptide compounds for detecting and treating type I diabetes
    Publication number: 20030220229
    Abstract: Proinsulin peptide compounds that modulate an immunological response by T cells of Type I diabetic subjects are disclosed. The proinsulin peptide compounds of the invention are preferably derived from a region of proinsulin that spans the junction between the B chain and C peptide of proinsulin. Pharmaceutical compositions comprising the proinsulin peptide compounds are also disclosed. An immunological response to a proinsulin peptide compound of the invention can be used as an indicator of Type I diabetes in a subject. Accordingly, the invention provides diagnostic assays for Type I diabetes using the proinsulin peptide compounds. Methods for inhibiting the development or progression of Type I diabetes in a subject by administering a proinsulin peptide compound are also disclosed.
    Type: Application
    Filed: January 16, 2003
    Publication date: November 27, 2003
    Applicant: Trustees of Dartmouth College
    Inventors: Ann C. Griffin, William F. Hickey
  • Detection methods for type I diabetes
    Patent number: 6509165
    Abstract: Proinsulin peptide compounds that modulate an immunological response by T cells of Type I diabetic subjects are disclosed. The proinsulin peptide compounds of the invention are preferably derived from a region of proinsulin that spans the junction between the B chain and C peptide of proinsulin. Pharmaceutical compositions comprising the proinsulin peptide compounds are also disclosed. An immunological response to a proinsulin peptide compound of the invention can be used as an indicator of Type I diabetes in a subject. Accordingly, the invention provides diagnostic assays for Type I diabetes using the proinsulin peptide compounds. Methods for inhibiting the development or progression of Type I diabetes in a subject by administering a proinsulin peptide compound are also disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 21, 2003
    Assignee: Trustees of Dartmouth College
    Inventors: Ann C. Griffin, William F. Hickey