Patents by Inventor Ann E. DeCamp

Ann E. DeCamp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one
    Patent number: 5650523
    Abstract: A process is described for the removal of a silyl protecting group from the 4-hydroxy group of a tetrahydro-pyran-2-one moiety.
    Type: Grant
    Filed: May 6, 1991
    Date of Patent: July 22, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Ann E. DeCamp, Alan T. Kawaguchi, Ralph P. Volante
  • Boronic acid compound
    Patent number: 5618934
    Abstract: The present invention is directed to a compound represented by the structural formula: ##STR1## wherein Z-- represents a negatively charged counterion.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: April 8, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Ann E. DeCamp, Edward J. J. Grabowski, Mark A. Huffman, Lyndon C. Xavier, Nobuyoshi Yasuda, Guo-Jie Ho, David J. Mathre
  • Chiral resolution process
    Patent number: 5457201
    Abstract: A chiral resolution process is described for the purification of a substituted chiral quinazoline, by salt formation with a resolving agent, followed by crystallization.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: October 10, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Nobuyoshi Yasuda, Ann E. DeCamp, Edward J. J. Grabowski
  • Preparation of 2-aryl carbapenems
    Patent number: 5442056
    Abstract: The present invention is directed to a process of making 2-aryl carbapenems of formula 1 from a compound of formula A.
    Type: Grant
    Filed: May 17, 1994
    Date of Patent: August 15, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Ann E. DeCamp, Edward J. J. Grabowski, Mark A. Huffman, Lyndon C. Xavier, Nobuyoshi Yasuda
  • Asymmetric synthesis of (S)-(-)-6-chloro-4- cyclopropyl-3,4-dihydro-4-[(2-pyridyl)ethynyl]-2(1H)-quinazolinone
    Patent number: 5434152
    Abstract: An asymmetric synthesis of (S)-(-)-6-chloro-4-cyclopropyl-3,4-dihydro-4-[(2-pyridyl)ethynyl]-2(1H)-qu inazolinone comprises the chiral addition of 2-pyridylacetylide to N.sup.1 -protected 6-chloro-4-cyclopropyl-2-quinazolinone followed by removal of the protecting group.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: July 18, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Mark A. Huffman, Nobuyoshi Yasuda, Ann E. DeCamp, Edward J. J. Grabowski
  • Process for certain (2R-trans)hexahydroaroquinolizines
    Patent number: 5064964
    Abstract: A unique process for preparing certain (2R-trans)hexahydroaroquinolizines, especially (2R-trans)-N-[2-(1,3,4,6,7,12b-hexahydro-2'-oxospiro[aro-[2,3-a]-quinolizi ne-2,4'-imidazolidin]-3'-yl) ethyl)-methanesulfonamide from (2R-trans)-N-[2-[(2-cyano-(1,3,4,6,7,12b-hexahydro-aro-[2,3-a]quinolizin-2 -yl)amino]ethyl]methanesulfonamide is described.
    Type: Grant
    Filed: April 9, 1990
    Date of Patent: November 12, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Ann E. DeCamp, Anthony O. King, Ralph P. Volante, Ichiro Shinkai
  • Processes and intermediates for the preparation of 5-oxygenated HMG-CoA reductase inhibitors
    Patent number: 5059696
    Abstract: This invention discloses novel intermediates and novel process for their preparation where said intermediates are useful for the preparation of 5-oxygenated derivatives (T) of lovastatin and analogs thereof at the 8-acyl side chain and 6-position of the polyhydronaphthyl ring. Said derivatives of lovastatin (T) and analogs thereof are useful in treating hypercholesterolemia and are disclosed in the U.S. Pat. No. 4,963,538.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: October 22, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Robert K. Anderson, Ann E. DeCamp, Alan T. Kawaguchi, Anthony O. King, Sander G. Mills, Ralph P. Volante
  • Process for certain (2R-trans)hexahydroaroquinolizines
    Patent number: 4942235
    Abstract: A unique process for preparing certain (2R-trans)hexahydroaroquinolizines, especially (2R-trans)-N-[2-(1,3,4,6,7,12b-hexahydro-2'-oxospiro[aro-[2,3-a]-quinolizi ne-2,4'-imidazolidin]-3'-yl)ethyl)-methanesulfonamide from (2R-trans)-N-[2-[(2-cyano-(1,3,4,6,7,12b-hexahydro-aro-[2,3-a]quinolizin-2 -yl)amino]ethyl]methanesulfonamide is described.
    Type: Grant
    Filed: March 16, 1989
    Date of Patent: July 17, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Ann E. DeCamp, Ralph P. Volante, Anthony O. King, Ichiro Shinkai
  • Hydrogenation process for the formation of tetrahydro HMG-CoA reductase inhibitors
    Patent number: 4864035
    Abstract: A novel hydrogenation process, using a homogenous iridium or rhodium catalyst for the reduction of both double bonds of des-(.alpha.-methylbutyryl)-C-8-hydroxy lovastatin and C-8-amino, C-8-alkoxy and C-6-substituted analogs, is disclosed.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: September 5, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Ann E. DeCamp, Thomas R. Verhoeven, Ichiro Shinkai
  • Acylation process for the synthesis of HMG-CoA reductase inhibitors
    Patent number: 4845237
    Abstract: A novel acylation process using an alkali metal bromide and a dialkylaminopyridine to form a sterically hindered ester functionality from an alkanoyl chloride and an alcohol is disclosed.
    Type: Grant
    Filed: April 15, 1987
    Date of Patent: July 4, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Ann E. DeCamp, Leonard M. Weinstock, Thomas R. Verhoeven
  • Hydrogenation process for the formation of 3,5-dihydro HMG-CoA reductase inhibitors
    Patent number: 4826999
    Abstract: A novel hydrogenation process, using a homogenous iridium or rhodium catalyst for selectively adding hydrogen to the 3,5 positions in the polyhydronaphthyl ring of lovastatin, simvastatin or C-8-acyl or C-6-substituted analogs thereof, is disclosed.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: May 2, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Ann E. DeCamp, Thomas R. Verhoeven, Ichiro Shinkai