Patents by Inventor Ann F. McCue

Ann F. McCue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human calcium channel compositions and methods
    Patent number: 7414110
    Abstract: Isolated DNA encoding each of human calcium channel ?1-, ?2-, ?- and ?-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: August 19, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue, Alison Gillespie, Daniel H. Feldman, Robert Brenner
  • Human calcium channel compositions and methods
    Publication number: 20040018510
    Abstract: Isolated DNA encoding each of human calcium channel &agr;1-, &agr;2-, &bgr;- and &ggr;-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Application
    Filed: February 27, 2003
    Publication date: January 29, 2004
    Applicant: Merck & Co., Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue, Alison Gillespie, Daniel H. Feldman, Robert Brenner
  • Human calcium channel compositions and methods
    Patent number: 6653097
    Abstract: Isolated DNA encoding each of human calcium channel &agr;1-, &agr;2-, &bgr;- and &ggr;-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: November 25, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue, Alison Gillespie, Daniel H. Feldman, Robert Brenner
  • Human calcium channel compositions and methods
    Patent number: 6387696
    Abstract: Isolated DNA encoding each of human calcium channel &agr;1-, &agr;2-, &bgr;- and &ggr;-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: May 14, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue
  • Human calcium channel compositions and methods
    Patent number: 6096514
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: August 1, 2000
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue
  • Recombinant human calcium channel .beta..sub.4 subunits
    Patent number: 6090623
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. In particular DNA clones encoding each of the .alpha..sub.1A-1, .alpha..sub.1A-2, .alpha..sub.1E-1, .alpha..sub.1C-2, .alpha..sub.1E-3, .beta..sub.3-1, .beta..sub.2C, .beta..sub.2D, .beta..sub.2E and .beta..sub.4 subunits of human calcium channels are provided. Cells and vectors containing the DNA, subunit specific antibodies and nucleic acid probes and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: July 18, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue
  • Assays of cells expressing human calcium channels containing .alpha..sub.1 .beta. subunits
    Patent number: 5876958
    Abstract: Human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunit encoding cDNAs, and related compositions and methods, are provided.
    Type: Grant
    Filed: September 23, 1994
    Date of Patent: March 2, 1999
    Assignee: SIBIA Neurosciences, Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Daniel H. Feldman, Ann F. McCue, Robert Brenner
  • DNA encoding human calcium channel .alpha.-.sub.1A, .beta..sub.1, .beta.-.sub.2, and .beta.-.sub.4 subunits, and assays using cells that express the subunits
    Patent number: 5874236
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.-and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: November 5, 1993
    Date of Patent: February 23, 1999
    Assignee: Sibia Neurosciences. Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Daniel H. Feldman, Ann F. McCue, Robert Brenner
  • Human calcium channel .alpha.-1C/.alpha.-1D, .alpha.-2, .beta.-1, and .gamma.subunits and cells expressing the DNA
    Patent number: 5851824
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: April 4, 1994
    Date of Patent: December 22, 1998
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Daniel H. Feldman, Ann F. McCue, Robert Brenner
  • Human calcium channel .alpha..sub.1, .alpha..sub.2, and .beta. subunits and assays using them
    Patent number: 5846757
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: December 8, 1998
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Daniel H. Feldman, Ann F. McCue, Robert Brenner
  • Human calcium channel compositions and methods
    Patent number: 5792846
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: August 11, 1998
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Daniel H. Feldman, Ann F. McCue, Robert Brenner
  • Assays for agonists and antagonists of recombinant human calcium channels
    Patent number: 5429921
    Abstract: Human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunit encoding cDNAs, and related compositions and methods, are provided.
    Type: Grant
    Filed: August 15, 1991
    Date of Patent: July 4, 1995
    Assignee: The Salk Institute Biotechnology/Industrial Assoc. Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Daniel H. Feldman, Ann F. McCue, Robert Brenner