Patents by Inventor Ann Graybiel

Ann Graybiel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genes integrating signal transduction pathways
    Patent number: 6987004
    Abstract: The present invention describes the identification, isolation, sequencing and characterization of two human CalDAG-GEF, and two human cAMP-GEF genes, which are associated with the Ras pathway. Also identified are CalDAG-GEF gene homologues in mice and cAMP-GEF gene homologues in rats. Nucleic acids and proteins comprising or derived from the CalDAG-GEFs and/or cAMP-GEFs are useful in screening and diagnosing certain Ras-associated cancers, in identifying and developing therapeutics for treatment of certain Ras-associated cancers, and in producing cell lines and transgenic animals useful as models of Ras-associated cancers.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: January 17, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Hiroaki Kawasaki, Ann Graybiel, David Housman