Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.

Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.

Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.

Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.

Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.

Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.

Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.

Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.

Abstract: Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.

Abstract: Isolated polypeptides comprising or consisting essentially of specific structural motifs (e.g., three ?-sheets and two ?-helices) are provided, wherein the polypeptides exhibit at least one cell signaling and/or other non-canonical activity of biological relevance. Also provided are polynucleotides encoding such polypeptides, binding agents that bind such polypeptides, analogs, variants and fragments of such polypeptides, etc., as well as compositions and methods of identifying and using any of the foregoing.

Abstract: Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.

Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.

Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.

Abstract: A cam follower having a clamp disposed on at least one end thereof. The follower includes two opposing sidewalls interconnected by a lower pallet. A roller is rotatably mounted to and disposed between the sidewalls via needled or journal bearings or other rotatable connection known in the art. A clamp is disposed about an end of the follower to induce compression force in the pallet and possibly act as the valve guide walls. The clamp increases the stiffness of the follower and induces compressive stress in the pallet area thereby increasing fatigue life. The clamp could also increase the length of the valve guide walls for better stability during engine assembly.

Abstract: A valve actuator for an engine includes a pivot socket having a dome with an improved lubrication passage. The actuator may be a finger follower with a body having spaced side walls connected adjacent opposite ends by first and second transverse webs. A cam follower, preferably a roller, having a cam engaging surface is supported on the side walls between the opposite ends of the body. The first web is engagable with a valve while the second web has a pivot socket with a dome having a generally spherical lower recess for engaging a pivot and a domed upper surface adjacent to the follower cam engaging surface. A lubrication passage extends through the dome from the lower recess to the upper surface. The passage includes an inverted inner channel formed in the recess and having upwardly converging sides meeting at a peak, and a connecting outer channel formed in the domed upper surface and having downwardly converging sides meeting at a valley.

Abstract: A rocker arm assembly includes a U-shaped rocker arm defined by a bottom wall and, two side walls depending upwardly therefrom where the side walls each have a central axle opening to support a transversely extending roller axle. A roller for rolling against a cam is rotatably supported on the roller axle through a roller bearing. The bottom wall of the rocker arm has a centrally located opening providing clearance for rotation of the roller and a spherical socket at a first end of the rocker arm to interface with an upper rounded end of a hydraulic lash adjuster. An oiling channel is provided along the bottom wall extending from the spherical socket, towards the roller, to terminate at the centrally located opening for channeling oil expelled from the hydraulic lash adjuster, wherein reciprocation of the rocker arm flings oil from the channel to the roller and roller bearing for lubrication.