Patents by Inventor Ann Holmes

Ann Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Yeast membrane protein expression system and its application in drug screening
    Publication number: 20050054108
    Abstract: The invention relates to an in vitro cell based expression system for overexpressing heterologous pump proteins associated with drug resistance into the membrane of the host cell for drug screening applications.
    Type: Application
    Filed: August 23, 2002
    Publication date: March 10, 2005
    Inventors: Brian Monk, Richard Cannon, Kenjirou Nakamura, Masakazu Niimi, Kyoko Niimi, Ann Holmes, Erwin Lamping, David Harding, Andre Goffeau, Anabelle Decottignies
  • Cholecystokinin antagonists, their preparation and therapeutic use
    Patent number: 5846942
    Abstract: Novel cholecystokinin antagonists useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with use of nicotine, diazepam, alcohol, cocaine, coffee, or opioids. The compounds of the invention are also useful in treating and/or preventing panic. Also disclosed are pharmaceutical compositions and methods of treatment using the antagonists as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds in diagnostic compositions.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: December 8, 1998
    Assignee: Warner-Lambert Company
    Inventors: David Christopher Horwell, Edward Roberts, Ann Holmes, Janak Khimchand Padia, William Howard Roark, Bruce David Roth, Bharat Kalidas Trivedi, Jurgen Kleinschroth
  • Cholecystokinin antagonists, their preparation and therapeutic use
    Patent number: 5593967
    Abstract: Novel cholecystokinin antagonists useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with use of nicotine, diazepam, alcohol, cocaine, coffee, or opioids. The compounds of the invention are also useful in treating and/or preventing panic. Also disclosed are pharmaceutical compositions and methods of treatment using the antagonists as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds in diagnostic compositions.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: January 14, 1997
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, Edward Roberts, Ann Holmes, Janak K. Padia, William H. Roark, Bruce D. Roth, Bharat K. Trivedi, Jurgen Kleinschroth, David C. Rees, Reginald S. Richardson
  • Amino acid analogs as CCK antagonists
    Patent number: 5331006
    Abstract: Novel unnatural dipeptoids useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. The compounds are agents useful for preventing the response to withdrawal from chronic treatment or use of nicotine, diazepam, alcohol, cocaine, caffeine, and opioids. The compounds are also useful in treating and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare diagnostic compositions.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: July 19, 1994
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, Julian Aranda, Corinne Augelli-Szafran, Hans-Jurgen Betche, Ann Holmes, Michael D. Mullican, Martyn C. Pritchard, Reginald S. Richardson, Edward Roberts, Bruce D. Roth, Bradley D. Tait, Bharat K. Trivedi, Uwe Trostmann, Paul C. Unangst
  • Novel N-(substituted-phenyl)-5-(substituted-2,5-dimethylphenoxy)-2,2-dimethylp entanamides
    Patent number: 4975456
    Abstract: Novel N-(substituted-phenyl)-5-(substituted-2,5-dimethylphenoxy)-2,2- dimethylpentanamides which are useful in preventing the intestinal absorption of cholesterol and also increasing high-density lipoprotein (HDL) cholesterol, as well as novel pharmaceutical compositions and methods of use, as well as processes for their manufacture are herein described.
    Type: Grant
    Filed: July 13, 1989
    Date of Patent: December 4, 1990
    Assignee: Warner-Lambert Company
    Inventors: Paul L. Creger, Milton L. Hoefle, Ann Holmes
  • Novel N-(substituted-phenyl)-5-(substituted-2,5-dimethylphenoxy)-2,2-dimethylp entanamides
    Patent number: 4882357
    Abstract: Novel N-(substituted-phenyl)-5-(substituted-2,5-dimethylphenoxy)-2,2-dimethylpen tan amides which are useful in preventing the intestinal absorption of cholesterol and also increasing high-density lipoprotein (HDL) cholesterol, as well as novel pharmaceutical compositions and methods of use, as well as processes for their manufacture are herein described.
    Type: Grant
    Filed: July 15, 1988
    Date of Patent: November 21, 1989
    Assignee: Warner-Lambert Company
    Inventors: Paul L. Creger, Milton L. Hoefle, Ann Holmes
  • Substituted anilides of oleic, linoleic, or linolenic acid as inhibitors of acyl-coa:cholesterol acyltransferase
    Patent number: 4751026
    Abstract: Certain trisubstituted anilides of oleic, linoleic, and linolenic acid are potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol.
    Type: Grant
    Filed: January 16, 1987
    Date of Patent: June 14, 1988
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, Ann Holmes
  • Saturated fatty acid amides as inhibitors of acyl-coa:cholesterol acyltransferase
    Patent number: 4743605
    Abstract: Certain substituted amides of saturated fatty acids are potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol.
    Type: Grant
    Filed: October 1, 1987
    Date of Patent: May 10, 1988
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, Ann Holmes, Bruce D. Roth
  • Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase
    Patent number: 4722927
    Abstract: Certain disubstituted pyrimidineamides of oleic and linoleic acids are potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: February 2, 1988
    Assignee: Warner-Lambert Company
    Inventor: Ann Holmes
  • Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase
    Patent number: 4716175
    Abstract: Certain substituted amides of saturated fatty acids are potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol.
    Type: Grant
    Filed: February 24, 1987
    Date of Patent: December 29, 1987
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, Ann Holmes, Bruce D. Roth
  • Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof
    Patent number: 4714762
    Abstract: Novel substituted benzimidazol-2-yl-phenoxyalkanoic acids, salts and esters thereof and 3H-imidazo[4,5-b]pyridin-2-yl phenoxy-alkanoic acid, salts, and esters which are useful as antiarteriosclerotic agents are disclosed. The compounds elevate the high density lipoprotein fraction of cholesterol and also lower the low density lipoprotein fraction of cholesterol. Methods for preparing and using the compounds are included.
    Type: Grant
    Filed: October 31, 1986
    Date of Patent: December 22, 1987
    Assignee: Warner-Lambert Company
    Inventors: Milton L. Hoefle, Ann Holmes, Charlotte D. Stratton
  • Substituted 2,2-dimethyl-5-phenoxypentanoic acid benzamides as anti-arteriosclerotic agents and method
    Patent number: 4554282
    Abstract: New substituted 2,2-dimethyl-5-phenoxypentanoic acid benzamides which are useful as anti-arteriosclerotic agents are disclosed. These compounds elevate the high density lipoprotein fraction of cholesterol, and also lower the low density lipoprotein fraction of cholesterol.
    Type: Grant
    Filed: August 5, 1983
    Date of Patent: November 19, 1985
    Assignee: Warner-Lambert Company
    Inventors: Ila Sircar, Ann Holmes
  • Substituted 2,2-dimethyl-5-phenoxypentanoic acid benzamides as anti-arteriosclerotic agents and method
    Patent number: 4413011
    Abstract: New substituted 2,2-dimethyl-5-phenoxypentanoic acid benzamides which are useful as anti-arteriosclerotic agents are disclosed. These compounds elevate the high density lipoprotein fraction of cholesterol, and also lower the low density lipoprotein fraction of cholesterol.
    Type: Grant
    Filed: February 26, 1981
    Date of Patent: November 1, 1983
    Assignee: Warner-Lambert Company
    Inventors: Ila Sircar, Ann Holmes