Patents by Inventor Ann J. Barbier

Ann J. Barbier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition and Methods for Treatment of Ornithine Transcarbamylase Deficiency
    Publication number: 20220072152
    Abstract: The present invention provides, among other things, methods of treating ornithine transcarbamylase deficiency, including administering to a subject in need of treatment a composition comprising an mRNA encoding an ornithine transcarbamylase protein at a low dose and at an administration interval such that at least one symptom or feature of the OTC deficiency is reduced.
    Type: Application
    Filed: September 27, 2021
    Publication date: March 10, 2022
    Inventors: Kim Askew, Jou-Ku Chung, Frank DeRosa, Michael Heartlein, Shrirang Karve, Thomas McCauley, Lianne Smith, Ann J. Barbier
  • Composition and methods for treatment of ornithine transcarbamylase deficiency
    Patent number: 11167043
    Abstract: The present invention provides, among other things, methods of treating ornithine transcarbamylase deficiency, including administering to a subject in need of treatment a composition comprising an mRNA encoding an ornithine transcarbamylase protein at a low dose and at an administration interval such that at least one symptom or feature of the OTC deficiency is reduced.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: November 9, 2021
    Assignee: TRANSLATE BIO, INC.
    Inventors: Kim Askew, Jou-Ku Chung, Frank DeRosa, Michael Heartlein, Shrirang Karve, Thomas McCauley, Lianne Smith, Ann J. Barbier
  • Composition and Methods for Treatment of Ornithine Transcarbamylase Deficiency
    Publication number: 20190192688
    Abstract: The present invention provides, among other things, methods of treating ornithine transcarbamylase deficiency, including administering to a subject in need of treatment a composition comprising an mRNA encoding an ornithine transcarbamylase protein at a low dose and at an administration interval such that at least one symptom or feature of the OTC deficiency is reduced.
    Type: Application
    Filed: December 20, 2018
    Publication date: June 27, 2019
    Inventors: Kim Askew, Jou-Ku Chung, Frank DeRosa, Michael Heartlein, Shrirang Karve, Thomas McCauley, Lianne Smith, Ann J. Barbier
  • HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS
    Publication number: 20120321559
    Abstract: Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
    Type: Application
    Filed: August 24, 2012
    Publication date: December 20, 2012
    Inventors: Richard Apodaca, Ann J. Barbier, Nicholas I. Carruthers, Leslie A. Gomez, John M. Keith, Timothy W. Lovenberg, Ronald L. Wolin
  • Hexahydro-pyrrolo-isoquinoline compounds
    Patent number: 8273762
    Abstract: Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: September 25, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Richard Apodaca, Ann J. Barbier, Nicholas I. Carruthers, Leslie A. Gomez, John M. Keith, Timothy W. Lovenberg, Ronald L. Wolin
  • HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS
    Publication number: 20100240648
    Abstract: Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
    Type: Application
    Filed: June 2, 2010
    Publication date: September 23, 2010
    Inventors: Richard Apodaca, Ann J. Barbier, Nicholas I. Carruthers, Leslie A. Gomez, John M. Keith, Timothy W. Lovenberg, Ronald L. Wolin
  • Hexahydro-pyrrolo-isoquinoline compounds
    Patent number: 7754882
    Abstract: Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: July 13, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Richard Apodaca, Ann J. Barbier, Nicholas I. Carruthers, Leslie A. Gomez, John M. Keith, Timothy W. Lovenberg, Ronald L. Wolin
  • Gap junction permeability assay
    Publication number: 20040126817
    Abstract: The present invention is a gap junction assay method and provides methods for both characterizing connexins and for identifying compounds that affect gap junctions function.
    Type: Application
    Filed: August 6, 2003
    Publication date: July 1, 2004
    Inventors: Ann J. Barbier, Bruce M. Baron