Abstract: A pressure-sensing device includes a device frame, a flexible membrane, a pressure sensor, and device electronics. The device frame includes a base surface that rests on a supporting structure and a frame attachment region located opposite to the base surface such that the frame attachment region is raised from the supporting structure when the base surface is resting on the supporting structure. The device frame also includes a seating surface. The flexible membrane is attached to the frame attachment region such that the device frame and the flexible membrane enclose a pressure chamber. The seating surface extends outward around the flexible membrane and the flexible membrane protrudes above the seating surface. The pressure sensor is configured to generate a pressure signal. The device electronics are configured to determine the pressure in the pressure chamber based on the pressure signal.

Abstract: A thermal device includes a first thermal unit, a second thermal unit, and device electronics. The first thermal unit includes a first plurality of semiconductor elements sandwiched between first and second thermal unit substrates. The first thermal unit substrate exchanges heat with a user. The second thermal unit includes a second plurality of semiconductor elements sandwiched between third and fourth thermal unit substrates. The third thermal unit substrate exchanges heat with the user. The device electronics are coupled to the first thermal unit and the second thermal unit. The device electronics operate the first thermal unit in a heating state in which the first thermal unit transfers heat to the user via the first thermal unit substrate. The device electronics operate the second thermal unit in a cooling state in which the second thermal unit removes heat from the user via the third thermal unit substrate.

Abstract: An apparatus is provided for processing and analysing a biological sample; the apparatus comprising: a. an apparatus housing; b. a sample extraction system to receive and hold the biological sample, and to extract the biological sample into a microfluidic chip; c. a thermal system to control the temperatures of the biological sample in the sample extraction system, and the extracted biological sample in the microfluidic chip; d. an optical system to illuminate the processed sample in the chip and to generate fluorescence from the sample in the chip, and an optical detector configured to detect the fluorescence; and e. at least one controller to control the sample extraction system, the thermal system and the optical system, and to determine one or more properties of the sample. The apparatus is configured to be handheld, and to extract and analyse the sample in situ, without requiring laboratory equipment.

Abstract: The present invention relates to a method for removing host cell DNA from a sample comprising infectious viral particles and host cell DNA by anion exchange chromatography in the presence of at least one of a non-ionic surfactant, a sugar and a protein and to a method for purifying recombinant infectious viral particles from a host cell culture employing such an anion exchange chromatography step.

Abstract: In one embodiment, a method includes accessing a first utterance of a content by a first speaker, generating first discrete speech units from the first utterance based on a speech-learning model, wherein each of the first discrete speech units is associated with a speech cluster, accessing second utterances of the content by second speakers different from the first speaker, and training a speech normalizer by processing each of the second utterances using the speech normalizer to generate second discrete speech units and updating the speech normalizer by using the first discrete speech units as an optimization target for the second discrete speech units associated with each of the second utterances.

Abstract: A method, according to one embodiment, includes, at a server in communication with a database and a network, receiving from a user a link to an internet webpage, via the network, analyzing, by the server, a Rich Site Summary (RSS) feed of the internet webpage and text in the internet webpage, categorizing, by the server, the internet webpage into a predetermined category based on the RSS feed of the internet webpage and the text in the internet webpage, creating, by the server, a summary of the internet webpage, utilizing the RSS feed of the internet webpage and the text in the internet webpage, identifying, by the server, an image from the internet webpage, resizing, by the server, the image from the internet webpage to create a resized image, including, by the server, the resized image in the summary of the internet webpage, upon determining that the resized image has a minimum size, meets predetermined aspect ratio limits, and is not repeated within the predetermined category, and in a webpage associated w

Abstract: The present invention relates generally to new chemical combinations and methods for their use in the treatment of cancer. In particular, the present invention relates to a particular Wnt modulator, i.e. a compound of formula (I), or a pharmaceutically acceptable salt, solvate or prodrug thereof in combination with a PARP inhibitor for use in the treatment of cancer.

Abstract: This disclosure relates to protease-cleavable IL-2 cytokine prodrugs. In some embodiments, the prodrugs comprise a pharmacokinetic modulator.

Abstract: The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for locating and treating a target nerve with integrated cold therapy and electrical stimulation systems are provided. For example, nerve stimulation and cryoneurolysis may be delivered concurrently or alternately with the cryo-stimulation device. In some embodiments, the device may be operated by a single operator or clinician. Accordingly, embodiments of the present disclosure may improve nerve targeting during cryoneurolysis procedures. Improvements in nerve localization and targeting may increase treatment accuracy, physician confidence in needle placement during treatment, and clinical efficacy and safety. In turn, such improvements may decrease overall treatment times, the number of repeat treatments, and the re-treatment rate.

Abstract: The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for locating and treating a target nerve with integrated cold therapy and electrical stimulation systems are provided. For example, nerve stimulation and cryoneurolysis may be delivered concurrently or alternately with the cryo-stimulation device. In some embodiments, the device may be operated by a single operator or clinician. Accordingly, embodiments of the present disclosure may improve nerve targeting during cryoneurolysis procedures. Improvements in nerve localization and targeting may increase treatment accuracy, physician confidence in needle placement during treatment, and clinical efficacy and safety. In turn, such improvements may decrease overall treatment times, the number of repeat treatments, and the re-treatment rate.

Abstract: Systems and methods for sharing protected media content are provided. Protected media content can be shared when at least a first and second user are proximately located. The first and second user can be bound or paired based on one or more identification indicia associated with first and second user devices utilized, owned, or operated by the first and second users, respectively. Upon pairing, media content from the first and second users' media content libraries can be shared. Additionally, proximate location can be leveraged to surface media content to other users, giving such other users the opportunity to discover new media content, and otherwise engage in transactions involving the new media content. Further still, the most popular media content associated with the second user or group of users proximate to the first user can be determined and used to prompt further interaction or display information regarding such popular media content.

Abstract: A method for dynamically generating a personalized handwriting character font includes inputting a plurality of handwriting sequentially through an input interface. Each handwriting describes a character. Then, the positions of strokes of characters in the input interface described by the plurality of handwriting are identified. Next, font characteristics of the characters are determined according to the positions of strokes in the input interface. A personalized handwriting character font characteristic is determined according to the font characteristics. Finally, a new character font file with a personalized handwriting character font is generated according to the personalized handwriting character font characteristic.

Abstract: The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for locating and treating a target nerve with integrated cold therapy and electrical stimulation systems are provided. For example, nerve stimulation and cryoneurolysis may be delivered concurrently or alternately with the cryo-stimulation device. In some embodiments, the device may be operated by a single operator or clinician. Accordingly, embodiments of the present disclosure may improve nerve targeting during cryoneurolysis procedures. Improvements in nerve localization and targeting may increase treatment accuracy, physician confidence in needle placement during treatment, and clinical efficacy and safety. In turn, such improvements may decrease overall treatment times, the number of repeat treatments, and the re-treatment rate.

Abstract: A method, according to one embodiment, includes, at a server in communication with a database and a network, receiving from a user a link to an internet webpage, via the network, analyzing, by the server, a Rich Site Summary (RSS) feed of the internet webpage and text in the internet webpage, categorizing, by the server, the internet webpage into a predetermined category based on the RSS feed of the internet webpage and the text in the internet webpage, creating, by the server, a summary of the internet webpage, utilizing the RSS feed of the internet webpage and the text in the internet webpage, identifying, by the server, an image from the internet webpage, resizing, by the server, the image from the internet webpage to create a resized image, including, by the server, the resized image in the summary of the internet webpage, upon determining that the resized image has a minimum size, meets predetermined aspect ratio limits, and is not repeated within the predetermined category, and in a webpage associated w

Abstract: Systems and/or methods for searching and aggregating internet web page updates. The system and/or method may further allow for customization of topics to update. Additionally, social media aspects of the system and/or method may allow for voting and commenting as well as sharing.

Abstract: A housing enclosure has a wall structure defining the enclosure, a first passage through the wall structure providing entry, and an escape door through the wall structure separate from the first passage, the escape door capable of opening only outward from inside the housing enclosure by an outward force against the escape door from within the enclosure.

Abstract: A method for dynamically generating a personalized handwriting character font includes inputting a plurality of handwriting sequentially through an input interface. Each handwriting describes a character. Then, the positions of strokes of characters in the input interface described by the plurality of handwriting are identified. Next, font characteristics of the characters are determined according to the positions of strokes in the input interface. A personalized handwriting character font characteristic is determined according to the font characteristics. Finally, a new character font file with a personalized handwriting character font is generated according to the personalized handwriting character font characteristic.

Abstract: Systems and methods for sharing protected media content are provided. Protected media content can be shared when at least a first and second user are proximately located. The first and second user can be bound or paired based on one or more identification indicia associated with first and second user devices utilized, owned, or operated by the first and second users, respectively. Upon pairing, media content from the first and second users' media content libraries can be shared. Additionally, proximate location can be leveraged to surface media content to other users, giving such other users the opportunity to discover new media content, and otherwise engage in transactions involving the new media content. Further still, the most popular media content associated with the second user or group of users proximate to the first user can be determined and used to prompt further interaction or display information regarding such popular media content.

Abstract: This invention relates to a method for real time communication with expression of personal emotions at the same time via instant messages and graphical representation in a simple minimised workflow. This technology enables users to easily convey their message and express their emotions at the time of conveyance of the message via instant messages more effectively as well as a more precise and accurate reflection of the users' emotions and moods at the time of communication via instant messages. This invention seeks to overcome the limitations of communication via instant messages currently whereby users are not able to convey their message and express their emotions at the time of conveyance of the message at the same time accurately and in real time.

Abstract: Systems, methods, and computer-readable storage media are provided for identifying dominant entity categories associated with target entities. A target entity is received and plural data sources are utilized to determine entity categories of which the target entity is a member and an initial confidence score for each of the entity categories. Each initial confidence score represents the likelihood that the associated entity category is a dominant category for the target entity. At least one data source includes information pertaining to plural entities arranged in a graph-based ontology that includes identifiers of respective entity categories of which the subject entities are members. Graph-based confidence score propagation is then utilized to incorporate information regarding entities determined to be related to the target entity and accolades associated with the target entity to alter the initial confidence scores provided for various entity categories of which the target entity is a member.