Patents by Inventor Ann Lovgren

Ann Lovgren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Factor II and fibrinogen for treatment of haemostatic disorders
    Patent number: 9433664
    Abstract: The present invention relates to normalizing impaired haemostasis comprising administering a clotting factor treatment selected from the group consisting of (1) FII; (2) PCC; and (3) a three factor combination of FH, FX and FVIIa. The clotting factor treatment can be administered in combination with fibrinogen. The clotting factor(s) can be recombinant human clotting factor(s).
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: September 6, 2016
    Assignee: MEDIMMUNE LIMITED
    Inventors: Ann Lovgren, Kenny Hansson
  • Compositions and methods for producing gamma-carboxylated proteins
    Patent number: 8697440
    Abstract: The present invention relates to methods and tools for producing large quantities of gamma-carboxylated protein comprising: (i) culturing a cell adapted to express a protein which requires gamma-carboxylation and ?-glutamyl carboxylase in a ratio of at least 10:1, under conditions suitable for expression of both proteins, and (ii) isolating gamma-carboxylated protein.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: April 15, 2014
    Assignee: Medimmune Limited
    Inventors: Christel Fenge, Ann Lövgren, Anders Thelin
  • Compositions and methods relating to proteins requiring gamma-carboxylation
    Patent number: 8304224
    Abstract: The present invention relates a host cell comprising an expression vector comprising a nucleic acid molecule encoding a protein requiring gamma-carboxylation and associated expression control sequences and a nucleic acid molecule encoding a vitamin K epoxido reductase and associated expression control sequences and a nucleic acid molecule encoding a ?-glutamyl carboxylase and associated control sequences. The invention further relates to a method of producing a protein requiring gamma-carboxylation in high yields.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: November 6, 2012
    Assignee: MedImmune Limited
    Inventor: Ann Lövgren
  • METHOD FOR PRODUCTION OF RECOMBINANT HUMAN THROMBIN
    Publication number: 20120258090
    Abstract: The present invention relates to a method is provided for producing recombinant human thrombin from recombinant prothrombin using recombinant ecarin having the sequence SEQ ID NO 2 or a homologue thereof.
    Type: Application
    Filed: June 15, 2012
    Publication date: October 11, 2012
    Applicant: MedImmune Limited
    Inventors: Anna Harrysson, Ann Lövgren
  • Method for production of recombinant human thrombin
    Patent number: 8206967
    Abstract: The present invention relates to compositions and methods for producing recombinant human thrombin using recombinant ecarin.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: June 26, 2012
    Assignee: MedImmune Limited
    Inventors: Anna Harrysson, Ann Lövgren
  • Compositions and methods relating to proteins requiring Gamma-Carboxylation
    Publication number: 20120077229
    Abstract: The present invention relates a host cell comprising an expression vector comprising a nucleic acid molecule encoding a protein requiring gamma-carboxylation and associated expression control sequences and a nucleic acid molecule encoding a vitamin K epoxido reductase and associated expression control sequences and a nucleic acid molecule encoding a ?-glutamyl carboxylase and associated control sequences. The invention further relates to a method of producing a protein requiring gamma-carboxylation in high yields.
    Type: Application
    Filed: June 23, 2011
    Publication date: March 29, 2012
    Inventor: Ann Lôvgren
  • Compositions and methods for producing gamma-carboxylated proteins
    Patent number: 7989193
    Abstract: The present invention relates a host cell comprising an expression vector comprising a nucleic acid molecule encoding a protein requiring gamma-carboxylation and associated expression control sequences and a nucleic acid molecule encoding a vitamin K epoxido reductase and associated expression control sequences and a nucleic acid molecule encoding a ?-glutamyl carboxylase and associated control sequences. The invention further relates to a method of producing a protein requiring gamma-carboxylation in high yields.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: August 2, 2011
    Assignee: MedImmune Limited
    Inventor: Ann Lövgren
  • COMPOSITIONS AND METHODS FOR PRODUCING GAMMA-CARBOXYLATED PROTEINS
    Publication number: 20110092429
    Abstract: The present invention relates to methods and tools for producing large quantities of gamma-carboxylated protein comprising: (i) culturing a cell adapted to express a protein which requires gamma-carboxylation and ?-glutamyl carboxylase in a ratio of at least 10:1, under conditions suitable for expression of both proteins, and (ii) isolating gamma-carboxylated protein.
    Type: Application
    Filed: November 19, 2010
    Publication date: April 21, 2011
    Inventors: Christel Fenge, Ann Lövgren, Anders Thelin
  • Methods for producing gamma-carboxylated proteins
    Patent number: 7842477
    Abstract: The present invention relates to methods and tools for producing large quantities of gamma-carboxylated protein comprising: (i) culturing a cell adapted to express a protein which requires gamma-carboxylation and ?-glutamyl carboxylase in a ratio of at least 10:1, under conditions suitable for expression of both proteins, and (ii) isolating gamma-carboxylated protein.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: November 30, 2010
    Assignee: AstraZeneca AB
    Inventors: Christel Fenge, Ann Lövgren, Anders Thelin
  • Method For Production of Recombinant Human Thrombin ['644]
    Publication number: 20090047273
    Abstract: The present invention relates to a method is provided for producing recombinant human thrombin from recombinant prothrombin using recombinant ecarin having the sequence SEQ ID NO 2 or a homologue thereof.
    Type: Application
    Filed: July 3, 2008
    Publication date: February 19, 2009
    Inventors: Anna Harrysson, Ann Lovgren
  • Host Cell Comprising a Vector for Production of Proteins Requiring Gamma-Carboxylation
    Publication number: 20080312127
    Abstract: The present invention relates a host cell comprising an expression vector comprising a nucleic acid molecule encoding a protein requiring gamma-carboxylation and associated expression control sequences and a nucleic acid molecule encoding a vitamin K epoxido reductase and associated expression control sequences and a nucleic acid molecule encoding a ?-glutamyl carboxylase and associated control sequences. The invention further relates to a method of producing a protein requiring gamma-carboxylation in high yields.
    Type: Application
    Filed: April 10, 2006
    Publication date: December 18, 2008
    Inventor: Ann Lovgren
  • Protein
    Publication number: 20050164367
    Abstract: The present invention relates to methods and tools for producing large quantities of gamma-carboxylated protein comprising: (i) culturing a cell adapted to express a protein which requires gamma-carboxylation and ?-glutamyl carboxylase in a ratio of at least 10:1, under conditions suitable for expression of both proteins, and (ii) isolating gamma-carboxylated protein.
    Type: Application
    Filed: October 14, 2004
    Publication date: July 28, 2005
    Applicant: AstraZeneca AB
    Inventors: Christel Fenge, Ann Lovgren, Anders Thelin