Patents by Inventor Ann Marie Leen

Ann Marie Leen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunosuppressive TGF-? signal converter
    Patent number: 10584158
    Abstract: Embodiments of the disclosure concern cell therapy methods and compositions utilizing cells expressing at least a chimeric TGF? receptor including the exodomain of a TGF?II receptor and an endodomain that is not from TGF? receptor, thereby converting the negative signal of TGF? for T cell proliferation into a T cell activation signal. In at least certain aspects, cells harboring the chimeric TGF? receptor also harbor one or more chimeric antigen receptors.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: March 10, 2020
    Assignee: Baylor College of Medicine
    Inventors: Juan Fernando Vera Valdes, Cliona M. Rooney, Ann Marie Leen, Norihiro Watanabe
  • Reversing the effects of the tumor microenvironment using chimeric cytokine receptors
    Patent number: 10548921
    Abstract: Disclosed are compositions and methods related to rendering ineffective Th1 T cells resistant to the inhibitory cytokine milieu present in a cancer microenvironment. Tumor-specific T cells are modified to employ a chimeric receptor that binds inhibitory/suppressive cytokines and converts their intracellular consequences to a Th1 immunostimulatory/activating signal. The T cells employ a chimeric antigen receptor having exodomains for IL10, IL13 and/or IL4 fused with the signal transducing endodomains for IL2 and/or IL7.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: February 4, 2020
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: Ann Marie Leen, Juan F. Vera
  • GENERATION OF CTL LINES WITH SPECIFICITY AGAINST MULTIPLE TUMOR ANTIGENS OR MULTIPLE VIRUSES
    Publication number: 20190264176
    Abstract: The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
    Type: Application
    Filed: May 9, 2019
    Publication date: August 29, 2019
    Inventors: Ann Marie Leen, Ulrike Gerdemann, Cliona M. Rooney, Juan F. V. Valdes, John R. Wilson
  • Generation of CTL lines with specificity against multiple tumor antigens or multiple viruses
    Patent number: 10385316
    Abstract: The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: August 20, 2019
    Assignees: Baylor College of Medicine, Wilson Wolf Manufacturing
    Inventors: Ann Marie Leen, Ulrike Gerdemann, Cliona M. Rooney, Juan F. Vera Valdes, John R. Wilson
  • GENERATION OF CTL LINES WITH SPECIFICITY AGAINST MULTIPLE TUMOR ANTIGENS OR MULTIPLE VIRUSES
    Publication number: 20190144826
    Abstract: The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
    Type: Application
    Filed: January 11, 2019
    Publication date: May 16, 2019
    Inventors: Ann Marie Leen, Ulrike Gerdemann, Cliona M. Rooney, Juan F. V. Valdes, John R. Wilson
  • IMMUNOGENIC ANTIGEN IDENTIFICATION FROM A PATHOGEN AND CORRELATION TO CLINICAL EFFICACY
    Publication number: 20180250384
    Abstract: Embodiments of the disclosure concern methods of identifying whether or not antigens from a particular pathogen are immunogenic, including the order of their immunogenicity. Other embodiments concern correlations between attributes of T cells and their clinical efficacy, such as mathematical representations thereof.
    Type: Application
    Filed: September 19, 2016
    Publication date: September 6, 2018
    Inventors: Ann Marie Leen, Pailbel Aguayo-Hiraldo, Ifigeneia Tzannou, Juan F. V. Valdes
  • PEPMIXES TO GENERATE MULTIVIRAL CTLS WITH BROAD SPECIFICITY
    Publication number: 20180187152
    Abstract: The present invention concerns methods of generating CTLs that are able to target at least one antigen from two or more viruses. The method includes exposing mixtures of peptides for different antigens to the same plurality of PBMCs and, at least in certain aspects, expanding the cells in the presence of IL4 and IL7.
    Type: Application
    Filed: February 26, 2018
    Publication date: July 5, 2018
    Inventors: Ann Marie Leen, Juan Fernando Vera Valdes, Cliona M. Rooney, Ulrike Gerdemann
  • BIPARTITE AND TRIPARTITE SIGNALING IMMUNE CELLS
    Publication number: 20170246278
    Abstract: Embodiments of the disclosure include compositions and methods effective for immunotherapy, such as for cancer. The embodiments include cells that recognize a combination of two signals or three signals present at the tumor microenvironment. In certain embodiments, the signals for antigen stimulation, co-stimulation, and cytokine signaling act through separate molecules, although in certain embodiments the signals for antigen stimulation and co-stimulation are transmitted through the same molecule.
    Type: Application
    Filed: October 19, 2015
    Publication date: August 31, 2017
    Inventors: Juan Fernando Vera Valdes, Ann Marie Leen, Sujita Sukumaran
  • GENERATION OF CTL LINES WITH SPECIFICITY AGAINST MULTIPLE TUMOR ANTIGENS OR MULTIPLE VIRUSES
    Publication number: 20160362658
    Abstract: The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
    Type: Application
    Filed: August 24, 2016
    Publication date: December 15, 2016
    Inventors: Ann Marie Leen, Ulrike Gerdemann, Cliona M. Rooney, Juan F. Vera, Valdes, John R. Wilson
  • IMMUNOSUPPRESSIVE TGF-ß SIGNAL CONVERTER
    Publication number: 20160075755
    Abstract: Embodiments of the disclosure concern cell therapy methods and compositions utilizing cells expressing at least a chimeric TGF? receptor including the exodomain of a TGF?II receptor and an endodomain that is not from TGF? receptor, thereby converting the negative signal of TGF? for T cell proliferation into a T cell activation signal. In at least certain aspects, cells harboring the chimeric TGF? receptor also harbor one or more chimeric antigen receptors.
    Type: Application
    Filed: April 17, 2014
    Publication date: March 17, 2016
    Inventors: Juan Fernando Vera Valdes, Cliona M. Rooney, Ann Marie Leen, Norihiro Watanabe
  • PEPMIXES TO GENERATE MULTIVIRAL CTLS WITH BROAD SPECIFICITY
    Publication number: 20150010519
    Abstract: The present invention concerns methods of generating CTLs that are able to target at least one antigen from two or more viruses. The method includes exposing mixtures of peptides for different antigens to the same plurality of PBMCs and, at least in certain aspects, expanding the cells in the presence of IL4 and IL7.
    Type: Application
    Filed: February 8, 2013
    Publication date: January 8, 2015
    Inventors: Ann Marie Leen, Juan Fernando Vera Valdes, Cliona M. Rooney, Ulrike Gerdemann
  • REVERSING THE EFFECTS OF THE TUMOR MICROENVIRONMENT USING CHIMERIC CYTOKINE RECEPTORS
    Publication number: 20140050709
    Abstract: Disclosed are compositions and methods related to rendering ineffective Th1 T cells resistant to the inhibitory cytokine milieu present in a cancer microenvironment. Tumor-specific T cells are modified to employ a chimeric receptor that binds inhibitory/suppressive cytokines and converts their intracellular consequences to a Th1 immunostimulatory/activating signal. The T cells employ a chimeric antigen receptor having exodomains for IL10, IL13 and/or IL4 fused with the signal transducing endodomains for IL2 and/or IL7.
    Type: Application
    Filed: April 5, 2012
    Publication date: February 20, 2014
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: Ann Marie Leen, Juan F. Vera