Patents by Inventor Ann Marie Madera

Ann Marie Madera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isoxazole hydroxamic acid compounds as LpxC inhibitors
    Patent number: 10029994
    Abstract: This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: July 24, 2018
    Assignee: Novartis AG
    Inventors: Jiping Fu, Xianming Jin, Subramanian Karur, Guillaume Lapointe, Ann Marie Madera, Zachary Kevin Sweeney
  • ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LpxC INHIBITORS
    Publication number: 20180030004
    Abstract: This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.
    Type: Application
    Filed: October 9, 2017
    Publication date: February 1, 2018
    Inventors: Jiping FU, Xianming JIN, Subramanian KARUR, Guillaume LAPOINTE, Ann Marie MADERA, Zachary Kevin SWEENEY
  • Isoxazole hydroxamic acid compounds as LpxC inhibitors
    Patent number: 9815804
    Abstract: This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: November 14, 2017
    Assignee: Novartis AG
    Inventors: Jiping Fu, Xianming Jin, Subramanian Karur, Guillaume Lapointe, Ann Marie Madera, Zachary Kevin Sweeney
  • ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LpxC INHIBITORS
    Publication number: 20170088525
    Abstract: This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.
    Type: Application
    Filed: December 12, 2016
    Publication date: March 30, 2017
    Inventors: Jiping FU, Xianming JIN, Subramanian KARUR, Guillaume LAPOINTE, Ann Marie MADERA, Zachary Kevin SWEENEY
  • Isoxazole hydroxamic acid compounds as LpxC inhibitors
    Patent number: 9549916
    Abstract: This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: January 24, 2017
    Assignee: Novartis AG
    Inventors: Jiping Fu, Xianming Jin, Subramanian Karur, Guillaume Lapointe, Ann Marie Madera, Zachary Kevin Sweeney
  • ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LpxC INHIBITORS
    Publication number: 20160166548
    Abstract: This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.
    Type: Application
    Filed: December 15, 2015
    Publication date: June 16, 2016
    Applicant: Novartis AG
    Inventors: Jiping FU, Xianming JIN, Subramanian KARUR, Guillaume LAPOINTE, Ann Marie MADERA, Zachary Kevin SWEENEY
  • Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives and uses thereof
    Patent number: 8513425
    Abstract: Compounds of the formula: or pharmaceutically acceptable salts thereof, wherein m, n, Ar, R1, R2, Ra and Rb are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: August 20, 2013
    Assignee: Roche Palo Alto LLC
    Inventors: Pravin Iyer, Clara Jeou Jen Lin, Stephen M. Lynch, Matthew C. Lucas, Ann Marie Madera, Kerem Erol Ozboya, Robert James Weikert, Ryan Craig Schoenfeld
  • HETEROARYL COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
    Publication number: 20130096149
    Abstract: The present invention provides compounds of Formula I: wherein R1, R2, R3, and X are as defined herein. The compounds of Formula (I) and pharmaceutical compositions thereof are useful for the treatment of cancer, and B-Raf-associated diseases.
    Type: Application
    Filed: June 23, 2011
    Publication date: April 18, 2013
    Applicant: NOVARTIS AG
    Inventors: Ann Marie Madera, Daniel Poon, Aaron Smith
  • HETEROARYL PYRROLIDINYL AND PIPERIDINYL KETONE DERIVATIVES AND USES THEREOF
    Publication number: 20120065225
    Abstract: Compounds of the formula: or pharmaceutically acceptable salts thereof, wherein m, n, Ar, R1, R2, Ra and Rb are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Application
    Filed: November 21, 2011
    Publication date: March 15, 2012
    Inventors: Pravin Iyer, Clara Jeou Jen Lin, Stephen M. Lynch, Matthew C. Lucas, Ann Marie Madera, Kerem Erol Ozboya, Robert James Weikert, Ryan Craig Schoenfeld
  • Pyrrolidinyl and piperidinyl ketone derivatives and uses thereof
    Patent number: 8084623
    Abstract: Compounds of the formula: or pharmaceutically acceptable salts thereof, wherein m, n, Ar, R1, R2, Ra and Rb are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: December 27, 2011
    Assignee: Roche Palo Alto LLC
    Inventors: Pravin Iyer, Clara Jeou Jen Lin, Stephen M. Lynch, Matthew C. Lucas, Ann Marie Madera, Kerem Erol Ozboya, Robert James Weikert, Ryan Craig Schoenfeld
  • Aryl pyrrolidinyl and piperidinyl ketone derivatives and uses thereof
    Publication number: 20090318493
    Abstract: Aryl and heteroaryl ketone compounds substituted with pyrrolidines and piperidines, that modulate serotonin norepinephrine and/or dopamine neurotransmission. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Application
    Filed: June 17, 2009
    Publication date: December 24, 2009
    Inventors: Pravin Iyer, Clara Jeou Jen Lin, Matthew C. Lucas, Stephen M. Lynch, Ann Marie Madera, Kerem Erol Ozboya, Ryan Craig Schoenfeld, Robert James Weikert
  • Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives and uses thereof
    Publication number: 20080146607
    Abstract: Compounds of the formula: or pharmaceutically acceptable salts thereof, wherein m, n, Ar, R1, R2, Ra and Rb are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Application
    Filed: December 18, 2007
    Publication date: June 19, 2008
    Inventors: Pravin Iyer, Clara Jeou Jen Lin, Stephen M. Lynch, Matthew C. Lucas, Ann Marie Madera, Kerem Erol Ozboya, Robert James Weikert, Ryan Craig Schoenfeld
  • 2,4-substituted indoles and methods of use
    Patent number: 7381739
    Abstract: The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, p and n are those defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: June 3, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Ann Marie Madera, Robert James Weikert
  • 2,7-substituted indoles
    Patent number: 7247651
    Abstract: The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, and n are those defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: July 24, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Ann Marie Madera, Robert James Weikert
  • 4-piperidinyl alkyl amine derivatives as muscarinic receptor antagonists
    Patent number: 6864266
    Abstract: This invention relates to the (R)-isomers of compounds which are generally muscarinic receptor antagonists and which are represented by Formula I: wherein p, R1, R2, R3 and A are as defined in the specification, or individual isomers, racemic or non-racemic mixtures of isomers, or acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use and preparation as therapeutic drugs.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: March 8, 2005
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Christine E. Brotherton-Pleiss, Ann Marie Madera, Robert James Weikert
  • Benzocycloalkylenylamine derivatives as muscarinic receptor antagonists
    Patent number: 6818645
    Abstract: This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S, or NR4, and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: November 16, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Robert James Weikert, Ann Marie Madera, Russell Stephen Stabler
  • Amino-tetralin derivatives as muscarinic receptor antagonists
    Patent number: 6806278
    Abstract: This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, or individual isomers, racemic or non-racemic mixtures of isomers, or acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use and preparation as therapeutic drugs.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: October 19, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Ann Marie Madera, Robert James Weikert
  • Amino-tetralin derivatives as muscarinic receptor antagonists
    Publication number: 20040092604
    Abstract: This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: 1
    Type: Application
    Filed: June 27, 2003
    Publication date: May 13, 2004
    Inventors: Ann Marie Madera, Robert James Weikert
  • 4-piperidinyl alkyl amine derivatives as muscarinic receptor antagonists
    Publication number: 20040092554
    Abstract: This invention relates to compounds which are generally muscarinic receptor antagonists and which are represented by Formula I: 1
    Type: Application
    Filed: July 1, 2003
    Publication date: May 13, 2004
    Inventors: Christine E. Brotherton-Pleiss, Ann Marie Madera, Robert James Weikert
  • 2,4-Substituted indoles and methods of use
    Publication number: 20040072844
    Abstract: The present invention provides a compound of the formula: 1
    Type: Application
    Filed: September 16, 2003
    Publication date: April 15, 2004
    Applicant: Roche Palo Alto LLC
    Inventors: Ann Marie Madera, Robert James Weikert