Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: A thermoplastic composition includes: (a) from about 5 wt % to about 75 wt % of a polycarbonate component; (b) from about 10 wt % to about 60 wt % of a low refractive index polyester that is miscible with polycarbonate; (c) from about 10 wt % to about 30% of an inherently dissipative polymer (IDP) having a refractive index at room temperature of at least 1.50; and (d) from about 5 wt % to about 75 wt % of a copolymer comprising polycarbonate and isophthalate terephthalate resorcinol (ITR).

Abstract: A thermoplastic composition includes: (a) from about 5 wt % to about 90 wt % of an aliphatic polyester-polycarbonate copolymer; (b) from about 5 wt % to about 65 wt % of a polycarbonate component different from the aliphatic polyester-polycarbonate copolymer in element (a); and (c) from greater than 5 wt % to about 30 wt % of an inherently dissipative polymer (IDP). The composition has a heat distortion temperature of at least 90° C. at 1.8 MPa and 4.0 mm as determined in accordance with ISO 75 and a notched Izod impact strength at 23° C. of at least 25 kJ/m2 as tested in accordance with ISO 180 at a thickness of 4.0 mm. In further aspects the composition has improved surface gloss properties as compared to a comparative composition that does not include the aliphatic polyester-polycarbonate copolymer of element (a).

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: The present disclosure relates to modified extracellular vesicles, e.g., exosomes, comprising a targeting moiety, wherein the targeting moiety can specifically bind to markers expressed on distinct immune cells (e.g., dendritic cells). Also provided herein are methods for using the exosomes to treat and/or prevent a range of medical disorders.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

Abstract: The present disclosure relates to modified extracellular vesicles, e.g, exosomes, comprising a targeting moiety (e.g., anti-CD3 targeting moiety), wherein the targeting moiety can specifically bind to markers expressed on distinct immune cells (e.g., T cells). Also provided herein are methods for using the exosomes to treat and/or prevent a range of medical disorders.

Abstract: A hair augmentation system is provided including a main portion. A clip notch may be provided in the main portion. A removable clip portion may complement the clip notch in the main portion. The main portion and the clip portion together may have a concave inner surface and a convex outer surface. At least one hair clip may be provided on the inner surface of each of the main portion and the clip portion. A flap cavity may be provided in the main portion. A hair flap may be provided on the main portion at the flap cavity. At least one hair comb may be provided on the hair flap. Imitation hair may be provided on the outer surface of the main portion.

Abstract: The invention described herein provides a method for the treatment of an oestrogen receptor positive breast cancer in a subject in need thereof comprising administering to said subject a therapeutically effective amount of a compound capable of inhibiting MPS1, wherein: (i) said subject has previously been treated with a CDK4/6 inhibitor; and/or (ii) said breast cancer is resistant to treatment with a CDK4/6 inhibitor.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: A network operator intermediates a cashless transaction by sending a payment device issuer an outbound clearing data file enriched with cleansed merchant data. Issuers that choose to participate in the merchant data cleansing service will be provided with the cleansed, and optionally augmented, merchant information. Providing this data to the issuer could be used to help reduce costs associated with “do not recognize” calls by cardholders, disputed charges, and charge-backs. With cleansed data provided in the clearing record, a device holder would be given access to this cleansed information about the merchant where a transaction took place through their statement. The present disclosure also provides for augmenting the clearing record data to include merchant-specific add-on and/or aggregate data not presently included in the transaction clearing record, yet useful to the issuer both in form and content.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.