Patents by Inventor Ann Oliver
Ann Oliver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210342255Abstract: Persistent storage includes measurements relating to components of a managed network. One or more processors may be configured to: obtain, from the persistent storage, an attainment measurement, a years of data measurement, and a tenure measurement all relating to a particular component of the managed network; determine a normalized attainment based on the attainment measurement, a mean attainment over a set of the components, and a standard deviation of attainment over the set of the components; determine a normalized years of data based on the years of data measurement and a maximum years of data available for the set of the components; determine a normalized tenure based on the tenure measurement, the years of data measurement, and a function of the normalized attainment; and determine an output for the particular component based on a combination of the normalized attainment, the normalized years of data, and the normalized tenure.Type: ApplicationFiled: April 30, 2020Publication date: November 4, 2021Inventors: Denise Ann Oliver, Bryanna Lynn Fuller
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Patent number: 11052141Abstract: Methods of mitigating the risk of rejection of an allograft or xenograft in an incompatible recipient by neutralizing one or more populations of circulating antibody cross-reactive with a carbohydrate antigen expressed by the allograft or xenograft. The method includes administering to the recipient by intravenous infusion a concentration of a synthetic antigen lipid construct sufficient to neutralize the one or more populations of circulating antibody in the recipient.Type: GrantFiled: November 9, 2018Date of Patent: July 6, 2021Assignee: KODE BIOTECH LIMITEDInventors: Stephen Micheal Henry, Caroline Ann Oliver
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Patent number: 10124047Abstract: Methods of neutralizing circulating antibody and mitigating the risk of clinically significant adverse responses to incompatible transfusions and transplantations are described. The methods comprise the administration to the subject of dispersible antigen-lipid constructs.Type: GrantFiled: July 9, 2015Date of Patent: November 13, 2018Assignee: KODE BIOTECH LIMITEDInventors: Stephen Micheal Henry, Caroline Ann Oliver
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Publication number: 20160030541Abstract: Methods of neutralizing circulating antibody and mitigating the risk of clinically significant adverse responses to incompatible transfusions and transplantations are described. The methods comprise the administration to the subject of dispersible antigen-lipid constructs.Type: ApplicationFiled: July 9, 2015Publication date: February 4, 2016Inventors: Stephen Michael HENRY, Caroline Ann OLIVER
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Patent number: 8686157Abstract: The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the process of the present invention.Type: GrantFiled: August 24, 2011Date of Patent: April 1, 2014Assignee: Vertex Pharmaceuticals IncorporatedInventors: John R. Snoonian, Patricia Ann Oliver-Shaffer
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Publication number: 20120157684Abstract: The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the process of the present invention.Type: ApplicationFiled: August 24, 2011Publication date: June 21, 2012Applicant: VERTEX PHARMACEUTICALS INCORPORATEDInventors: John R. Snoonian, Patricia Ann Oliver-Shaffer
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Patent number: 8034950Abstract: The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the process of the present invention.Type: GrantFiled: August 15, 2006Date of Patent: October 11, 2011Assignee: Vertex Pharmaceuticals IncorporatedInventors: John R. Snoonian, Patricia Ann Oliver-Shaffer
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Publication number: 20110229511Abstract: Methods of neutralising circulating antibody and mitigating the risk of clinically significant adverse responses to incompatible transfusions and transplantations are described. The methods comprise the administration to the subject of dispersible antigen-lipid constructs.Type: ApplicationFiled: October 2, 2009Publication date: September 22, 2011Inventors: Stephen Michael Henry, Caroline Ann Oliver
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Publication number: 20070026377Abstract: Methods and compositions are provided for increasing the survival of nucleated mammalian cells following drying and rehydration. The methods include introducing a disaccharide such as trehalose into said cells, optionally including heat shock proteins, apoptosis inhibitors, and arbutin, drying said cells, and rehydrating them. The invention further provides nucleated mammalian cells that have increased capacity to survive, divide and, in some cases, differentiate, following drying and rehydration. The cells comprise a disaccharide and one or more of the following: a heat shock protein, an apoptosis inhibitor, and arbutin.Type: ApplicationFiled: October 18, 2004Publication date: February 1, 2007Applicant: The Regents of the University of CaliforniaInventors: John Crowe, Fern Tablin, Ann Oliver, Kamran Jamil, Xiaocui Ma, James Clegg, Willem Wolkers, Thurein Htoo
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Patent number: 7115746Abstract: The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the process of the present invention.Type: GrantFiled: February 10, 2004Date of Patent: October 3, 2006Assignee: Vertex Pharmaceuticals IncorporatedInventors: John R. Snoonian, Patricia Ann Oliver-Shaffer
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Publication number: 20060134084Abstract: A dehydrated composition is provided that includes freeze-dried platelets. The platelets are loaded with trehalose which preserves biological properties during freeze-drying and rehydration. The trehalose loading is conducted at a temperature of from greater than about 25° C. to less than about 40° C., most preferably at 37° C., with the loading solution having trehalose in an amount from about 10 mM to about 50 mM. These freeze-dried platelets are substantially shelf-stable and are rehydratable so as to have a normal response to an agonist, for example, thrombin, with virtually all of the platelets participating in clot formation within about three minutes at 37° C.Type: ApplicationFiled: December 22, 2005Publication date: June 22, 2006Applicant: Regents of the University of California Office of Technology TransferInventors: Willem Wolkers, John Crowe, Fern Tablin, Ann Oliver, Naomi Walker
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Publication number: 20060134069Abstract: A dehydrated composition is provided that includes freeze-dried erythrocytic cells. Alcohol (e.g., sterol or cholesterol) is at least partially removed from erythrocytic cells including erythrocytic membranes. After removal of at least part of the alcohol, the erythrocytic cells have a low phase transition temperature range, an intermediate phase transition temperature range, and a high phase transition temperature range. The erythrocytic cells may be loaded with an oligosaccharide (e.g., trehalose) which preserves biological properties during freeze-drying and rehydration. A process for increasing cooperativity of a phase transition of an erythrocytic cell. A process for preserving and/or increasing the survival of dehydrated erythrocytic cells, including storing dehydrated erythrocytic cells having a residual water content equal to or less than about 0.30 gram of water per gram of dry weight erythrocytic cells.Type: ApplicationFiled: July 12, 2004Publication date: June 22, 2006Applicant: The Regents of the University of CaliforniaInventors: John Crowe, Lois Crowe, Fern Tablin, Willem Wolkers, Nelly Tsvetkova, Ann Oliver
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Publication number: 20050112686Abstract: A method for loading a biological sample comprising loading a biological sample with a solute by fluid phase endocytosis to produce an internally loaded biological sample. Within the biological sample a first matter (e.g., a vesicle) having the solute fuses with a second matter (e.g., a lysosome) to produce a fused matter containing the solute. Loading of the biological sample includes transferring the solute from the fused matter into cytoplasm within the biological sample.Type: ApplicationFiled: November 25, 2003Publication date: May 26, 2005Inventors: John Crowe, Fern Tablin, Willem Wolkers, Ann Oliver, Kamran Jamil, Joong-Hyuck Auh, Thurein Htoo
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Publication number: 20050048460Abstract: A method for stabilizing a biological material (e.g., blood platelets, cells, etc.) comprising treating a biological material with an amphiphilic agent (e.g., an amphiphilic compound, such as a surfactant, or pluronic or arbutin) to stabilize the biological material. At least one carbohydrate (e.g., trehalose or a trehalose-sucrose mixture) may be combined with the amphiphilic agent for treating the biological material. The treated biological material may be dehydrated. A biological material produced in accordance with the method for treating the biological material.Type: ApplicationFiled: May 24, 2004Publication date: March 3, 2005Applicant: The Regents of the University of CaliforniaInventors: John Crowe, Fern Tablin, Ann Oliver, Kamran Jamil
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Publication number: 20040230058Abstract: The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the process of the present invention.Type: ApplicationFiled: February 10, 2004Publication date: November 18, 2004Inventors: John R. Snoonian, Patricia Ann Oliver-Shaffer
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Patent number: 6281677Abstract: The present invention is a method for defect locating marking and analysis of thin film hard disks. Initially, the hard disk is disposed in a disk drive and the disk is formatted with sector identification lines and data written into data tracks. During the data writing process a disk surface defect is identified by its sector, track and byte location. The hard disk is then marked such that the defect can be located at a later time. The erased bands aid in later locating the defect. After the defect locating erasures have been completed for each defect found on the disk, the disk is removed from the hard disk drive for further analysis. The disk is then placed on the stage of a microscope and ferromagnetic fluid is applied to the disk in order to make the erased tracks visible. The ferromagnetic fluid is applied out to the end of the track erasure of the track that includes the defect, without application of ferromagnetic fluid to the defect itself.Type: GrantFiled: November 4, 1999Date of Patent: August 28, 2001Assignee: International Business Machines CorporationInventors: Michael Craig Cosci, Paul Marion Green, Lisa Ann Oliver