Patents by Inventor Ann Progulske-Fox

Ann Progulske-Fox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of virulence polynucleotides for diagnosis, treatment, and monitoring of periodontal diseases
    Patent number: 8703436
    Abstract: The invention provides compositions and methods for the detection of Porphyromonas gingivalis and for the treatment and prevention of diseases and infections caused by P. gingivalis.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: April 22, 2014
    Assignee: University of Florida Research Foundation
    Inventors: Ann Progulske-Fox, Jeffrey Daniel Hillman, Martin Handfield
  • Methods and compositions for the treatment of cancers and pathogenic infections
    Patent number: 8545841
    Abstract: The subject application provides small compounds that are able to suppress autophagy in various cells. These compounds are useful in augmenting the existing treatments of various cancers and microbial/parasitic infections. Thus, the subject application also provides methods of treating various types of cancers and microbial/parasitic infections. Also provided by the subject application are methods of suppressing the expansion of autophagosomes within cells or individuals and inhibiting the lipidation of autophagy-related protein 8 (Atg8).
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: October 1, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: William A. Dunn, Debra E. Akin, Ann Progulske-Fox, David A. Ostrov
  • Identification of antigens for use in the diagnosis, treatment, and monitoring of periodontal diseases
    Patent number: 8420340
    Abstract: Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetemcomitans.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: April 16, 2013
    Assignee: University of Florida Research Foundation
    Inventors: Martin Handfield, Jeffrey Daniel Hillman, Ann Progulske-Fox
  • Identification of Actinobacillus actinomycetemcomitans Antigens for Use in the Diagnosis, Treatment, and Monitoring of Periodontal Diseases
    Publication number: 20110294146
    Abstract: Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetemcomitans.
    Type: Application
    Filed: May 20, 2011
    Publication date: December 1, 2011
    Inventors: Martin Handfield, Jeffrey Daniel Hillman, Ann Progulske-Fox
  • Microbial polynucleotides expressed during infection of a host
    Patent number: 8034571
    Abstract: Disclosed are methods for obtaining antigens that are expressed by pathogenic microorganism during an infection process, as well as the antigens so obtained. Also disclosed are isolated polynucleotides encoding said antigens, recombinant polypeptides expressed from the isolated polypeptides, antibodies capable of forming immune complexes with the obtained antigens, and various other compositions useful in the detection, diagnosis, prevention and/or treatment of a microbial infection. The methods of the invention utilize pooled sera from patients who have partly or completely undergone infection by a microbial organism in order to obtain genes that are expressed during in vivo but not during in vitro growth of the microbial organism.
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: October 11, 2011
    Assignee: Oragenics, Inc.
    Inventors: Martin Handfield, Ann Progulske-Fox, L. Jeannine Brady, Jeffrey D. Hillman
  • Identification of antigens for use in the diagnosis, treatment and monitoring of periodontal diseases
    Patent number: 7981631
    Abstract: Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetemcomitans.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: July 19, 2011
    Assignee: University of Florida Research Foundation
    Inventors: Martin Handfield, Jeffrey Daniel Hillman, Ann Progulske-Fox
  • Identification of antigens for use in the diagnosis, treatment, and monitoring of periodontal diseases
    Patent number: 7851171
    Abstract: Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetecomitans.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: December 14, 2010
    Assignee: University of Florida Research Foundation
    Inventors: Martin Handfield, Jeffrey Daniel Hillman, Ann Progulske-Fox
  • Genes of W83 involved in invasion of human cells
    Patent number: 7838259
    Abstract: Compositions and methods are provided for detection and treatment of Porphyromonas gingivalis infection.
    Type: Grant
    Filed: February 1, 2006
    Date of Patent: November 23, 2010
    Assignee: University of Florida Research Foundation
    Inventors: Paulo Henrique Rodrigues, Ann Progulske-Fox
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCERS AND PATHOGENIC INFECTIONS
    Publication number: 20100285012
    Abstract: The subject application provides small compounds that are able to suppress autophagy in various cells. These compounds are useful in augmenting the existing treatments of various cancers and microbial/parasitic infections. Thus, the subject application also provides methods of treating various types of cancers and microbial/parasitic infections. Also provided by the subject application are methods of suppressing the expansion of autophagosomes within cells or individuals and inhibiting the lipidation of autophagy-related protein 8 (Atg8).
    Type: Application
    Filed: January 5, 2009
    Publication date: November 11, 2010
    Applicant: University of FLorida Research Foundation Inc.
    Inventors: William A. Dunn, JR., Debra E. Akin, Ann Progulske-Fox, David A. Ostrov
  • Identification of Actinobacillus actinomycetemcomitans Antigens for Use in the Diagnosis, Treatment, and Monitoring of Periodontal Diseases
    Publication number: 20090142782
    Abstract: Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetecomitans.
    Type: Application
    Filed: January 9, 2009
    Publication date: June 4, 2009
    Inventors: Martin Handfield, Jeffrey Daniel Hillman, Ann Progulske-Fox
  • Identification of antigens for use in the diagnosis, treatment, and monitoring of periodontal diseases
    Patent number: 7498143
    Abstract: Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetemcomitans.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: March 3, 2009
    Assignee: University of Florida Research Foundation
    Inventors: Martin Handfield, Jeffrey Daniel Hillman, Ann Progulske-Fox
  • Genes of Porphyromonas Gingivalis W83 Involved in Invasion of Human Cells
    Publication number: 20080311596
    Abstract: Compositions and methods are provided for detection and treatment of Porphyromonas gingivalis infection.
    Type: Application
    Filed: February 1, 2006
    Publication date: December 18, 2008
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION
    Inventors: Paulo Henrique Rodrigues, Ann Progulske-Fox
  • Identification of Porphyromonas gingivalis virulence polynucleotides for diagnosis, treatment, and monitoring of periodontal diseases
    Publication number: 20080299591
    Abstract: The invention provides compositions and methods for the detection of Porphyromonas gingivalis and for the treatment and prevention of diseases and infections caused by P. gingivalis.
    Type: Application
    Filed: July 18, 2008
    Publication date: December 4, 2008
    Inventors: Ann Progulske-Fox, Jeffrey Daniel Hillman, Martin Handfield
  • Identification of virulence polynucleotides for diagnosis, treatment, and monitoring of periodontal diseases
    Patent number: 7416852
    Abstract: The invention provides compositions and methods for the detection of Porphyromonas gingivalis and for the treatment and prevention of diseases and infections caused by P. gingivalis.
    Type: Grant
    Filed: August 10, 2004
    Date of Patent: August 26, 2008
    Assignee: University of Florida Research Foundation
    Inventors: Ann Progulske-Fox, Jeffrey Daniel Hillman, Martin Handfield
  • Identification of actinobacillus actinomycetemcomitans antigens for use in the diagnosis, treatment, and monitoring of periodontal diseases
    Publication number: 20060160159
    Abstract: Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetemcomitans.
    Type: Application
    Filed: January 17, 2006
    Publication date: July 20, 2006
    Inventors: Martin Handfield, Jeffrey Hillman, Ann Progulske-Fox
  • Identification of antigens for use in the diagnosis, treatment, and monitoring of periodontal diseases
    Patent number: 7052860
    Abstract: Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetemcomitans.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: May 30, 2006
    Assignee: University of Florida Research Foundation
    Inventors: Martin Handfield, Jeffrey Daniel Hillman, Ann Progulske-Fox
  • Identification of Porphyromonas gingivalis virulence polynucleotides for diagnosis, treatment, and monitoring of periodontal diseases
    Publication number: 20060078950
    Abstract: The invention provides compositions and methods for the detection of Porphyromonas gingivalis and for the treatment and prevention of diseases and infections caused by P. gingivalis.
    Type: Application
    Filed: August 10, 2004
    Publication date: April 13, 2006
    Inventors: Ann Progulske-Fox, Jeffrey Hillman, Martin Handfield
  • IDENTIFICATION OF ACTINOBACILLUS ACTINOMYCETEMCOMITANS ANTIGENS FOR USE IN THE DIAGNOSIS, TREATMENT, AND MONITORING OF PERIODONTAL DISEASES
    Publication number: 20060035293
    Abstract: Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetemcomitans.
    Type: Application
    Filed: November 28, 2001
    Publication date: February 16, 2006
    Inventors: Martin Handfield, Jeffrey Hillman, Ann Progulske-Fox
  • Methods and compositions for prevention of angioproliferation
    Publication number: 20050019318
    Abstract: The invention provides pharmaceutical compositions comprising Porphyromonas gingivalis protease and hemagglutinin polypeptides that have anti-angiogenic activity and methods for their use.
    Type: Application
    Filed: May 2, 2002
    Publication date: January 27, 2005
    Inventors: Emil Kozarov, Ann Progulske-Fox
  • Methods and compositions for angioproliferative disorder treatment
    Publication number: 20020192206
    Abstract: An invention is provided whereby methods and compositions having angiostatic activity are utilized to treat angioproliferative disorders, to prevent conception, and to treat a wide variety of pathologies in which it is desirable to limit the production of new vasculature. Specifically, compositions containing proteinases derived from the pathogen Porphyromonas gingivalis capable of treating cancer through disruption of cell-cell and cell-matrix adhesion bonds associated with malignant tumor proliferation are disclosed.
    Type: Application
    Filed: May 5, 2001
    Publication date: December 19, 2002
    Inventors: Emil V. Kozarov, Ann Progulske-Fox