Abstract: Example embodiments relate to determining prognosis and treatment based on clinical-pathologic factors and continuous multigene-expression profile scores. An example embodiment includes a non-transitory, computer-readable medium having instructions stored thereon. The instructions, when executed by a processor, cause the processor to execute a method. The method includes obtaining a plurality of clinical-pathologic factors related to a patient. The clinical-pathologic factors are indicative of risk associated with melanoma. The method also includes obtaining a continuous multigene-expression profile score for the patient. The continuous multigene-expression profile score is based on multiple genes whose expressions are related to melanoma. Further, the method includes determining, based on the plurality of clinical-pathologic factors and the continuous multigene-expression profile score, a risk score for the patient.