Patents by Inventor Ann Shinnar

Ann Shinnar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE), pharmaceutical methods and compositions employing such inhibitors, and processes for evaluating the NHE-inhibitory efficacy of compounds
    Publication number: 20060183928
    Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
    Type: Application
    Filed: April 15, 2004
    Publication date: August 17, 2006
    Inventors: Michael Zasloff, Ann Shinnar, William Kinney, Steven Jones
  • Treatment of neovascularization disorders with squalamine
    Publication number: 20060166950
    Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
    Type: Application
    Filed: March 16, 2006
    Publication date: July 27, 2006
    Inventors: Michael Zasloff, Ann Shinnar, William Kinney, Steven Jones
  • Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE), pharmaceutical methods and compositions employing such inhibitors, and processes for evaluating the NHE-inhibitory efficacy of compounds
    Publication number: 20050261508
    Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
    Type: Application
    Filed: February 1, 2005
    Publication date: November 24, 2005
    Inventors: Michael Zasloff, Ann Shinnar, William Kinney, Steven Jones
  • Treatment of neovascularization disorders with squalimine
    Patent number: 6962909
    Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: November 8, 2005
    Assignee: Genaera Corporation
    Inventors: Michael Zasloff, Ann Shinnar, William Kinney, Steven Jones
  • Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE), pharmaceutical methods and compositions employing such inhibitors, and processes for evaluating the NHE-inhibitory efficacy of compounds
    Publication number: 20030149287
    Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
    Type: Application
    Filed: November 2, 2001
    Publication date: August 7, 2003
    Applicant: Genaera Corporation
    Inventors: Michael Zasloff, Ann Shinnar, William Kinney, Steven Jones
  • Method of inhibiting proliferation of cells by administering an aminosterol compound
    Patent number: 5994336
    Abstract: A method of inhibiting the proliferation of a wide variety of cells is described. This method includes administering an effective amount of a compound having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof. The proliferation of the following types of cells can be inhibited by this method: lymphocytes, fibroblasts, epithelial cells, smooth muscle cells, and human ovarian cancer cells.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 30, 1999
    Assignee: Magainin Pharmaceuticals Inc.
    Inventors: Michael Zasloff, Ann Shinnar, William Kinney, Meena Rao
  • Certain aminosterol compounds and pharmaceutical compositions including these compounds
    Patent number: 5847172
    Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 8, 1998
    Assignee: Magainin Pharmaceuticals Inc.
    Inventors: Michael Zasloff, Ann Shinnar, William Kinney, Steven Jones
  • Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
    Patent number: 5840936
    Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 24, 1998
    Assignee: Magainin Pharmaceuticals Inc.
    Inventors: Michael Zasloff, Ann Shinnar, Meena Rao, William Kinney
  • Aminosterol compounds and a method of treating infection using the aminosterol compounds
    Patent number: 5840740
    Abstract: Disclosed are aminosterol compounds 1360 and 1361: ##STR1## which can be obtained in isolated or purified form from the liver of the dogfish shark.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 24, 1998
    Assignee: Magainin Pharmaceuticals Inc.
    Inventors: Michael Zasloff, Ann Shinnar, William Kinney, Meena Rao
  • Method of inhibiting profileration of cells by administering an aminosterol compound
    Patent number: 5795885
    Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also disclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 18, 1998
    Assignee: Magainin Pharmaceuticals Inc.
    Inventors: Michael Zasloff, Ann Shinnar, William Kinney, Mark Anderson, Jon Williams, Michael McLane
  • Family of linear antimicrobial peptides from hagfish intestine
    Patent number: 5734015
    Abstract: A new family of linear antimicrobial peptide from hagfish intestine is described. This invention relates to proteins with antimicrobial properties isolated from hagfish intestine and their corresponding chemical sequences.
    Type: Grant
    Filed: June 18, 1996
    Date of Patent: March 31, 1998
    Assignee: Magainin Pharmaceuticals Inc.
    Inventors: Ann Shinnar, Michael A. Zasloff, Thomas Uzzell