Abstract: Provided herein are methods of producing a heterologous polypeptide and compositions comprising same.

Abstract: The present invention relates to an edible container made of liquid, sugar, and one or more hydrocolloids. The edible container may hold hot or cold liquids for extended periods of time.

Abstract: The present invention relates to an edible container made of agar, cane sugar, water, light corn syrup, fruit or vegetable juice, a flavoring agent, and a coloring agent. The edible container may hold hot or cold liquids for extended periods of time.

Abstract: The present invention relates to an edible container made of liquid, sugar, and one or more hydrocolloids. The edible container may hold hot or cold liquids for extended periods of time.

Abstract: Provided herein are methods for inducing and stabilizing an enzyme activity. Optionally, the enzyme is in a microorganism capable of producing the enzyme. In some embodiments, the enzyme can be nitrile hydratase, amidase, or asparaginase I. Provided are compositions comprising enzymes or microorganisms having induced and/or stabilized activity. Also provided are methods of delaying a plant development process by exposing a plant or plant part to the enzymes or microorganisms having induced and/or stabilized activity.

Abstract: The invention provides the identification of the presence of polypeptides with ROS kinase activity in mammalian lung cancer. In some embodiments, the polypeptide with ROS kinase activity is the result of a fusion between a ROS-encoding polynucleotide and a polynucleotide encoding a second (non-ROS) polypeptide. Three different fusion partners of ROS are described, namely proteins encoded by the FIG gene, the SLC34A2 gene, and the CD74 gene. The invention enables new methods for determining the presence of a polypeptide with ROS kinase activity in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer (e.g., an lung cancer).

Abstract: The invention provides the identification of the presence of mutant ROS protein in human cancer. In some embodiments, the mutant ROS are FIG-ROS fusion proteins comprising part of the FIG protein fused to the kinase domain of the ROS kinase. In some embodiments, the mutant ROS is the overexpression of wild-type ROS in cancerous tissues (or tissues suspected of being cancerous) where, in normal tissue of that same tissue type, ROS is not expressed or is expressed at lower levels. The mutant ROS proteins of the invention are anticipated to drive the proliferation and survival of a subgroup of human cancers, particularly in cancers of the liver (including bile duct), pancreas, kidney, and testes. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ROS polypeptides (e.g., a FIG-ROS(S) fusion polypeptide), probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides.

Abstract: The invention discloses 990 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.

Abstract: This is a computerized system that leverages web technologies to provide the mechanism by which the public-at-large can self-initiate the report of an incident, and whereby the system captures data pertinent to the incident in the form of a logical association of all elements of the incident; including, but not limited to: victim, reporting party, location, narrative, incident details, and suspect information. This invention is a remarkable, innovative, and unprecedented system and method that: 1) enables the public-at-large to electronically create an incident report via the Internet, an intranet, or an extranet; 2) guides the public through the process of creating an incident report; 3) profiles the elements of the incident through iterative sets of logically related questions and answers; and, 4) automatically notifies one or more law enforcement agencies of the submission of an incident report by a member of the public-at-large.

Abstract: A bedding article for supporting infants with gastroesophageal reflux condition comprising a band of bedding material defining at least a partial covering for the crib mattress and forming a tensile load carrying connection therewith and a infant support sling connected to the band of the bedding material.

Abstract: A bedding article for supporting infants with gastroesophageal reflux condition comprising a band of bedding material defining at least a partial covering for the crib mattress and forming a tensile load carrying connection therewith and a infant support sling connected to the band of the bedding material.