Patents by Inventor Ann Westerholm-Parvinen

Ann Westerholm-Parvinen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 11827891
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: November 28, 2023
    Assignee: VTT TECHNICAL RESEARCH CENTRE OF FINLAND LTD
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja Penttilä, Markku Saloheimo
  • PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF
    Publication number: 20220290165
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: November 18, 2021
    Publication date: September 15, 2022
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher LANDOWSKI, Anne HUUSKONEN, Juhani SAARINEN, Ann WESTERHOLM-PARVINEN, Anne KANERVA, Jari NATUNEN, Anna-Liisa HÄNNINEN, Noora SALOVUORI, Merja PENTTILÄ, Markku SALOHEIMO
  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 11180767
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: November 23, 2021
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja Penttilä, Markku Saloheimo
  • PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF
    Publication number: 20210139922
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: June 26, 2020
    Publication date: May 13, 2021
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher LANDOWSKI, Anne HUUSKONEN, Juhani SAARINEN, Ann WESTERHOLM-PARVINEN, Anne KANERVA, Jari NATUNEN, Anna-Liisa HÄNNINEN, Noora SALOVUORI, Merja PENTTILÄ, Markku SALOHEIMO
  • Multiple proteases deficient filamentous fungal cells and methods of use thereof
    Patent number: 10988791
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: April 27, 2021
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Multiple Proteases Deficient Filamentous Fungal Cells and Methods of Use Thereof
    Publication number: 20200347426
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: July 20, 2020
    Publication date: November 5, 2020
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 10731168
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 4, 2020
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja Penttilä, Markku Saloheimo
  • Multiple proteases deficient filamentous fungal cells and methods of use thereof
    Patent number: 10724063
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: July 28, 2020
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Multiple Proteases Deficient Filamentous Fungal Cells and Methods of Use Thereof
    Publication number: 20200087696
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: November 22, 2019
    Publication date: March 19, 2020
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Multiple protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 10544440
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: January 28, 2020
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Production of glycoproteins with mammalian-like N-glycans in filamentous fungi
    Patent number: 10513724
    Abstract: The present disclosure relates to compositions and methods useful for the production of recombinant glycoproteins in filamentous fungal cells, such as Trichoderma cells, wherein at least 90% (mol %), preferably at least 95% of the total neutral N-glycans of said produced recombinant glycoprotein are mammalian-like N-glycans. More specifically, the invention provides a filamentous fungal cell comprising i. one or more mutations that reduces or eliminates one or more endogenous protease activity compared to a parental filamentous fungal cell which does not have said mutation(s); ii. a polynucleotide encoding a heterologous catalytic subunit of oligosaccharyl transferase; iii. a recombinant polynucleotide for increasing ?1, 2 mannosidase activity;and, iv. a recombinant polynucleotide encoding said heterologous glycoprotein.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: December 24, 2019
    Assignee: GLYKOS FINLAND OY
    Inventors: Jari Natunen, Anne Leppänen, Heidi Salminen, Jukka Hiltunen, Anne Kanerva, Annamari Heiskanen, Ann Westerholm-Parvinen, Georg Schmidt, Anne Huuskonen, Eero Mustalahti, Christopher Landowski, Markku Saloheimo, Juhani Saarinen, Benjamin Patrick Sommer, Ramon Wahl, Christian Ostermeier, Bernhard Helk
  • Multiple Protease Deficient Filamentous Fungal Cells and Methods of Use Thereof
    Publication number: 20190309338
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: March 11, 2019
    Publication date: October 10, 2019
    Applicants: Glykos Finland OY, Novartis AG
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Multiple proteases deficient filamentous fungal cells and methods of use thereof
    Patent number: 10435731
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: October 8, 2019
    Assignee: Glykos Finland Oy
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF
    Publication number: 20190233831
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: January 18, 2019
    Publication date: August 1, 2019
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja PENTTILÄ, Markku Saloheimo
  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 10240159
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: March 26, 2019
    Assignee: Glykos Finland OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hanninen, Noora Salovuori, Merja Penttila, Markku Saloheimo
  • Regulatory Protein Deficient Trichoderma Cells and Methods of Use Thereof
    Publication number: 20180215797
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: August 11, 2016
    Publication date: August 2, 2018
    Applicant: Glykos Finland OY
    Inventors: Christopher Landowski, Ann Westerholm-Parvinen, Markku Saloheimo
  • Protease Deficient Filamentous Fungal Cells and Methods of Use Thereof
    Publication number: 20170275634
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: December 12, 2016
    Publication date: September 28, 2017
    Applicant: Glykos Finland OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hanninen, Noora Salovuori, Merja Penttila, Markku Saloheimo
  • Production of fucosylated glycoproteins
    Patent number: 9695454
    Abstract: Described herein are compositions including filamentous fungal cells, such as Trichoderma fungal cells, having reduced protease activity and expressing fucosylation pathway. Further described herein are methods for producing a glycoprotein having fucosylated N-glycan, using genetically modified filamentous fungal cells, for example, Trichoderma fungal cells, as the expression system.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: July 4, 2017
    Assignee: GLYKOS FINLAND OY
    Inventors: Jari Natunen, Ann Westerholm-Parvinen, Hanna Salo, Jussi Joensuu, Heli Viskari, Christopher Landowski, Anne Huuskonen, Anne Kanerva, Anna-Liisa Hanninen, Noora Salovuori, Merja Penttila, Juhani Saarinen, Markku Saloheimo
  • Method for improved protein production in filamentous fungi
    Patent number: 9695430
    Abstract: The present invention relates to a method for genetically modifying a filamentous fungus host for improved protein production. The method comprises that a filamentous fungus host is genetically modified to overexpress or to be deficient of specific genes. The invention relates also to the modified hosts. Furthermore, the invention relates to a method for improved production or for producing an improved composition of proteins, such as cellulases, hemicellulases, other proteins involved in the degradation of lignocellulosic material, or other proteins, in a filamentous fungus host.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: July 4, 2017
    Assignee: Teknologian Tutkimuskeskus VTT OY
    Inventors: Tiina Pakula, Markku Saloheimo, Mari Hakkinen, Ann Westerholm-Parvinen, Merja Penttila, Marika Vitikainen
  • PRODUCTION OF GLYCOPROTEINS WITH MAMMALIAN-LIKE N-GLYCANS IN FILAMENTOUS FUNGI
    Publication number: 20170159094
    Abstract: The present disclosure relates to compositions and methods useful for the production of recombinant glycoproteins in filamentous fungal cells, such as Trichoderma cells, wherein at least 90% (mol %), preferably at least 95% of the total neutral N-glycans of said produced recombinant glycoprotein are mammalian-like N-glycans. More specifically, the invention provides a filamentous fungal cell comprising i. one or more mutations that reduces or eliminates one or more endogenous protease activity compared to a parental filamentous fungal cell which does not have said mutation(s); ii.a polynucleotide encoding a heterologous catalytic subunit of oligosaccharyl transferase; iii. a recombinant polynucleotide for increasing ?1, 2 mannosidase activity;and, iv. a recombinant polynucleotide encoding said heterologous glycoprotein.
    Type: Application
    Filed: July 21, 2015
    Publication date: June 8, 2017
    Applicant: GLYKOS FINLAND OY
    Inventors: Jari Natunen, Anne Leppänen, Heidi Salminen, Jukka Hiltunen, Anne Kanerva, Annamari Heiskanen, Ann Westerholm-Parvinen, Georg Schmidt, Anne Huuskonen, Eero Mustalahti, Christopher Landowski, Markku Saloheimo, Juhani Saarinen, Benjamin Patrick Sommer, Ramon Wahl, Christian Ostermeier, Bernhard Helk