Abstract: A self-healing hydraulic seal is provided. The self-healing hydraulic seal is prepared from a water-swellable elastomeric composition comprising a base polymer and a plant-based polysaccharide.

Abstract: Small molecule potentiatiors to potassium channels (such as Kv7 potentiators—which are also called KCNQ potentiators), compositions including such compounds, and methods of using such compounds for the treatment of Amyotrophic Lateral Sclerosis and other neurological diseases caused by changes in motor neuron excitability, including, but not limited to, primary lateral sclerosis, pseudobulbar palsy, progressive bulbar palsy, progressive muscular atrophy and epilepsy.

Abstract: This invention relates to the detection and diagnosis of tuberculosis. More specifically, the invention relates to new biomarkers and combinations thereof that enable the accurate detection and diagnosis of tuberculosis.

Abstract: The present invention relates to formulations and methods for treatment of sexual dysfunction in females diagnosed with both sexual dysfunction and controlled hypertension.

Abstract: Further according to the present disclosure, there are methods for promoting egg maturation in assisted reproductive technologies, such as in in vitro fertilization (IVF) or in an embryo transfer (ET) process. There are also methods for decreasing the rate of ovarian hyperstimulation syndrome (OHSS), providing comparable or improved pregnancy rates, decreasing the time to pregnancy, and inhibiting premature ovulation. The methods include the step of administering a therapeutically effective amount of an active pharmaceutical ingredient of 2-(N-acetyl-D-tyrosyl-trans-4-hydroxy-L-prolyl-L-asparaginyl-L-threonyl-L-phenylalanyl) hydrazinocarbonyl-L-leucyl-N?-methyl-L-arginyl-L-tryptophanamide or a pharmaceutically acceptable salt thereof.

Abstract: Further according to the present disclosure, there are methods for promoting egg maturation in assisted reproductive technologies, such as in in vitro fertilization (IVF) or in an embryo transfer (ET) process. There are also methods for decreasing the rate of ovarian hyperstimulation syndrome (OHSS), providing comparable or improved pregnancy rates, decreasing the time to pregnancy, and inhibiting premature ovulation. The methods include the step of administering a therapeutically effective amount of an active pharmaceutical ingredient of 2-(N-acetyl-D-tyrosyl-trans-4-hydroxy-L-prolyl-L-asparaginyl-L-threonyl-L-phenylalanyl) hydrazinocarbonyl-L-leucyl-N?-methyl-L-arginyl-L-tryptophanamide or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to formulations and methods for treatment of sexual dysfunction in females diagnosed with both sexual dysfunction and controlled hypertension.

Abstract: Further according to the present disclosure, there are methods for promoting egg maturation in assisted reproductive technologies, such as in in vitro fertilization (IVF) or in an embryo transfer (ET) process. There are also methods for decreasing the rate of ovarian hyperstimulation syndrome (OHSS), providing comparable or improved pregnancy rates, decreasing the time to pregnancy, and inhibiting premature ovulation. The methods include the step of administering a therapeutically effective amount of an active pharmaceutical ingredient of 2-(N-acetyl-D-tyrosyl-trans-4-hydroxy-L-prolyl-L-asparaginyl-L-threonyl-L-phenylalanyl) hydrazinocarbonyl-L-leucyl-N?-methyl-L-arginyl-L-tryptophanamide or a pharmaceutically acceptable salt thereof.

Abstract: A self-healing hydraulic seal is provided. The self-healing hydraulic seal is prepared from a water-swellable elastomeric composition comprising a base polymer and a plant-based polysaccharide.

Abstract: Further according to the present disclosure, there are methods for promoting egg maturation in assisted reproductive technologies, such as in in vitro fertilization (IVF) or in an embryo transfer (ET) process. There are also methods for decreasing the rate of ovarian hyper-stimulation syndrome (OHSS), providing comparable or improved pregnancy rates, decreasing the time to pregnancy, and inhibiting premature ovulation. The methods include the step of administering a therapeutically effective amount of an active pharmaceutical ingredient of 2-(N-acetyl-D-tyrosyl-trans-4-hydroxy-L-prolyl-L-asparaginyl-L-threonyl-L-phenylalanyl) hydrazinocarbonyl-L-leucyl-N?-methyl-L-arginyl-L-tryptophanamide or a pharmaceutically acceptable salt thereof.

Abstract: A self-healing hydraulic seal is provided. The self-healing hydraulic seal is prepared from a water-swellable elastomeric composition comprising a base polymer and a plant-based polysaccharide.

Abstract: The present invention relates to formulations and methods for treatment of sexual dysfunction in females diagnosed with both sexual dysfunction and controlled hypertension.

Abstract: Further according to the present disclosure, there are methods for promoting egg maturation in assisted reproductive technologies, such as in in vitro fertilization (IVF) or in an embryo transfer (ET) process. There are also methods for decreasing the rate of ovarian hyperstimulation syndrome (OHSS), providing comparable or improved pregnancy rates, decreasing the time to pregnancy, and inhibiting premature ovulation. The methods include the step of administering a therapeutically effective amount of an active pharmaceutical ingredient of 2-(N-acetyl-D-tyrosyl-trans-4-hydroxy-L-prolyl-L-asparaginyl-L-threonyl-L-phenylalanyl) hydrazinocarbonyl-L-leucyl-N?-methyl-L-arginyl-L-tryptophanamide or a pharmaceutically acceptable salt thereof.

Abstract: A net-shaped composite plenum housing body for a differential assembly having a pump is disclosed. The plenum housing body can include a low pressure inlet and a high pressure outlet configured to receive a control valve. The plenum housing body can also define a fluid inlet channel in fluid communication with the low pressure inlet via a first internal port and can be configured to be in fluid communication with an inlet side of the pump when the plenum housing body is assembled onto the differential assembly. The plenum housing body can also define a fluid outlet channel in fluid communication with the high pressure outlet via a second internal port and can be configured to be in fluid communication with an outlet side of the pump when the plenum housing body is assembled onto the differential assembly. The plenum housing body can also be formed as a net-shape fiber reinforced plastic material including chopped fibers, for example, chopped fiberglass fibers, and an epoxy resin.

Abstract: Further according to the present disclosure, there are methods for promoting egg maturation in assisted reproductive technologies, such as in in vitro fertilization (IVF) or in an embryo transfer (ET) process. There are also methods for decreasing the rate of ovarian hyperstimulation syndrome (OHSS), providing comparable or improved pregnancy rates, decreasing the time to pregnancy, and inhibiting premature ovulation. The methods include the step of administering a therapeutically effective amount of an active pharmaceutical ingredient of 2-(N-acetyl-D-tyrosyl-trans-4-hydroxy-L-prolyl-L-asparaginyl-L-threonyl-L-phenylalanyl) hydrazinocarbonyl-L-leucyl-N?-methyl-L-arginyl-L-tryptophanamide or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides pharmaceutical formulations for anti-IL-17 antibodies. These anti-IL-17 antibody pharmaceutical formulations can be used to treat rheumatoid arthritis, psoriasis, ankylosing spondilitis, psoriatic arthritis or multiple myeloma.

Abstract: A self-healing hydraulic seal is provided. The self-healing hydraulic seal is prepared from a water-swellable elastomeric composition comprising a base polymer and a plant-based polysaccharide.

Abstract: The present disclosure relates to a simplified roots-type blower having an improved sound signature. The roots-type blower includes a rotor bore housing having a molded, one-piece polymeric construction. The rotor bore housing defines a first rotor bore and a second rotor bore. The rotor bore housing also defines a first bearing pocket corresponding to the first rotor bore and a bearing pocket corresponding to the second rotor bore axis. The rotor bore housing further defining a timing gear chamber.

Abstract: Systems and methods for managing regulatory information. The system comprises a submission controller, a registration controller and a submission archive controller. The submission controller may manage a submission structure, and allow users to search for documents in a content management system and add the documents to the submission structure. The registration controller may manage product registration information and health authority interactions globally, and capture, view and take actions upon product registrations. The submission archive controller may allow users to access a complete history of regulatory submissions and correspondence globally, with an easy to use interface. The three controllers reside in a single system that allows them to interact seamlessly with each other.