Patents by Inventor Ann Ying-An Chen

Ann Ying-An Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vitro immune synapse system and method of in vitro evaluating immune response using the same
    Patent number: 11834647
    Abstract: The present invention relates to an in vitro immune synapse system and a method of in vitro evaluating immune response using the same. The in vitro immune synapse system includes antigen-presenting cells (APCs) and at least one cell type of several specific T cell subtypes isolated from peripheral blood mononuclear cells (PBMCs), all of which is from a same individual of pigs. When a test sample is co-cultured in the in vitro immune synapse system for a given period, it can be determined that the test sample is immunogenic, immunostimulatory or not according to the immunization-related changes of these cells, thereby potentially replacing some kinds of animal experimentation.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: December 5, 2023
    Assignee: National Pingtung University of Science and Technology
    Inventors: Hso-Chi Chaung, Wen-Bin Chung, Ann Ying-An Chen, Mei-Li Wu
  • IN VITRO IMMUNE SYNAPSE SYSTEM AND METHOD OF IN VITRO EVALUATING IMMUNE RESPONSE USING THE SAME
    Publication number: 20200407683
    Abstract: The present invention relates to an in vitro immune synapse system and a method of in vitro evaluating immune response using the same. The in vitro immune synapse system includes antigen-presenting cells (APCs) and at least one cell type of several specific T cell subtypes isolated from peripheral blood mononuclear cells (PBMCs), all of which is from a same individual of pigs. When a test sample is co-cultured in the in vitro immune synapse system for a given period, it can be determined that the test sample is immunogenic, immunostimulatory or not according to the immunization-related changes of these cells, thereby potentially replacing some kinds of animal experimentation.
    Type: Application
    Filed: September 15, 2020
    Publication date: December 31, 2020
    Inventors: Hso-Chi Chaung, Wen-Bin Chung, Ann Ying-An Chen, Mei-Li Wu
  • IN VITRO IMMUNE SYNAPSE SYSTEM AND METHOD OF IN VITRO EVALUATING IMMUNE RESPONSE USING THE SAME
    Publication number: 20200190471
    Abstract: The present invention relates to an in vitro immune synapse system and a method of in vitro evaluating immune response using the same. The in vitro immune synapse system includes antigen-presenting cells (APCs) and at least one cell type of several specific T cell subtypes isolated from peripheral blood mononuclear cells (PBMCs), all of which is from a same individual of pigs. When a test sample is co-cultured in the in vitro immune synapse system for a given period, it can be determined that the test sample is immunogenic, immunostimulatory or not according to the immunization-related changes of these cells, thereby potentially replacing some kinds of animal experimentation.
    Type: Application
    Filed: December 13, 2018
    Publication date: June 18, 2020
    Inventors: Hso-Chi Chaung, Wen-Bin Chung, Ann Ying-An Chen, Mei-Li Wu