Patents by Inventor Anna Agnieska WASIEL

Anna Agnieska WASIEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE MODIFICATION OF A GLYCOPROTEIN USING A BETA-(1,4)-N-ACETYLGALACTOSAMINYL TRANSFERASE OR A MUTANT THEREOF
    Publication number: 20170226554
    Abstract: The present invention relates to a process for the modification of a glycoprotein, using a ?-(1,4)-N-acetylgalactosaminyltransferase or a mutant thereof. The process comprises the step of contacting a glycoprotein comprising a glycan comprising a terminal GlcNAc-moiety, in the presence of a ?-(1,4)-N-acetylgalactosaminyl-transferase or a mutant thereof, with anon-natural sugar-derivative nucleotide. The non-natural sugar-derivative nucleotideis according to formula (3), wherein A is selected from the group consisting of —N3; —C(0)R3; —C?C—R4; —SH; —SC(0)R8; —SC(V)OR8, wherein V is O or S; —X wherein X is selected from the group consisting of F, Cl, Br and I; —OS(0)2R5; an optionally substituted C2-C24 alkyl group; an optionally substituted terminal C2-C24 alkenyl group; and an optionally substituted terminal C3-C24 alkenyl group.
    Type: Application
    Filed: August 4, 2015
    Publication date: August 10, 2017
    Applicant: Synaffix B.V.
    Inventors: Anna Agnieska WASIEL, Floris Louis VAN DELFT, Sander Sebastiaan VAN BERKEL