Patents by Inventor Anna Aldovini
Anna Aldovini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7122180Abstract: The present invention pertains to mutated, non-infectious HIV viral particles, vectors for production of such particles and vaccines employing such vectors. The non-infectious particles are obtained by introducing a number of inactivating mutations into a native viral genome. These mutations are designed so as to minimize the probability of genetic reversion to an infectious virus, while retaining the basic protein content and immunogenic properties of a wild-type virion. The altered viral genome expresses proteins that can assemble into non-infectious particles which contain immunogenic components of the virus, but which are unable to infect cells. The preferred mutations are introduced in at least one amino acid position of the nucleocapsid (NC) protein in combination with at least one other mutation in an amino acid position of the reverse transcriptase (RT) protein or the In protein.Type: GrantFiled: October 23, 2001Date of Patent: October 17, 2006Assignee: Children's Medical Center CorporationInventor: Anna Aldovini
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Publication number: 20030158131Abstract: The present invention pertains to mutated, non-infectious HIV viral particles, vectors for production of such particles and vaccines employing such vectors. The non-infectious particles are obtained by introducing a number of inactivating mutations into a native viral genome. These mutations are designed so as to minimize the probability of genetic reversion to an infectious virus, while retaining the basic protein content and immunogenic properties of a wild-type virion. The altered viral genome expresses proteins that can assemble into non-infectious particles which contain immunogenic components of the virus, but which are unable to infect cells. The preferred mutations are introduced in at least one amino acid position of the NC protein in combination with at least one other mutation in an amino acid position of the RT protein or the In protein.Type: ApplicationFiled: October 23, 2001Publication date: August 21, 2003Inventor: Anna Aldovini
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Patent number: 6355486Abstract: A method of transforming slow-growing mycobacteria, such as M. bovis BCG, M. leprae, M. tuberculosis, M. avium, M. intracellulare and M. africanum; a method of manipulating genomic DNA of slow-growing mycobacteria through homologous recombination; a method of producing homologously recombinant (HR) slow-growing mycobacteria in which heterologous DNA is integrated into the genomic DNA at a homologous locus; homologously recombinant (HR) slow-growing mycobacteria having heterologous DNA integrated into their genomic DNA at a homologous locus; and mycobacterial DNA useful as a genetic marker.Type: GrantFiled: June 29, 1999Date of Patent: March 12, 2002Assignee: Whitehead Institute for Biomedical ResearchInventors: Anna Aldovini, Richard A. Young
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Patent number: 6022745Abstract: A method of transforming slow-growing mycobacteria, such as M. bovis BCG, M. leprae, M. tuberculosis M. avium, M. intracellulare and M. africanum; a method of manipulating genomic DNA of slow-growing mycobacteria through homologous recombination; a method of producing homologously recombinant (HR) slow-growing mycobacteria in which heterologous DNA is integrated into the genomic DNA at a homologous locus; homologously recombinant (HR) slow-growing mycobacteria having heterologous DNA integrated into their genomic DNA at a homologous locus; and mycobacterial DNA useful as a genetic marker.Type: GrantFiled: June 7, 1995Date of Patent: February 8, 2000Assignee: Whitehead Institute for Biomedical ResearchInventors: Anna Aldovini, Richard A. Young
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Patent number: 5919458Abstract: This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described.Type: GrantFiled: June 7, 1995Date of Patent: July 6, 1999Assignee: Whitehead Institute for Biomedical ResearchInventors: Anna Aldovini, Richard A. Young, Mark B. Feinberg, Didier Trono, David Baltimore
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Patent number: 5866403Abstract: A method of transforming slow-growing mycobacteria, such as M. bovis BCG, M. leprae, M. tuberculosis M. avium, M. intracellulare and M. africanum; a method of manipulating genomic DNA of slow-growing mycobacteria through homologous recombination; a method of producing homologously recombinant (HR) slow-growing mycobacteria in which heterologous DNA is integrated into the genomic DNA at a homologous locus; homologously recombinant (HR) slow-growing mycobacteria having heterologous DNA integrated into their genomic DNA at a homologous locus; and mycobacterial DNA useful as a genetic marker.Type: GrantFiled: May 19, 1995Date of Patent: February 2, 1999Assignee: Whitehead Institute for Biomedical ResearchInventors: Anna Aldovini, Richard A. Young
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Patent number: 5861282Abstract: This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described.Type: GrantFiled: September 7, 1993Date of Patent: January 19, 1999Assignee: Whitehead Institute for Biomedical ResearchInventors: Anna Aldovini, Richard A. Young, Mark B. Feinberg, Didier Trono, David Baltimore
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Patent number: 5830475Abstract: The present invention relates to recombinant mycobacteria, particularly recombinant M. bovis BCG, which express heterologous DNA encoding a product (protein or polypeptide) of interest, such a protein or polypeptide (e.g., an antigen) against which an immune response is desired, or a cytokine.Type: GrantFiled: June 5, 1995Date of Patent: November 3, 1998Assignee: Whitehead Institute for Biomedical ResearchInventors: Anna Aldovini, Richard A. Young
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Patent number: 5807723Abstract: A method of transforming slow-growing mycobacteria, such as M. bovis BCG, M. leprae, M. tuberculosis M. avium, M. intracellulare and M. africanum; a method of manipulating genomic DNA of slow-growing mycobacteria through homologous recombination; a method of producing homologously recombinant (HR) slow-growing mycobacteria in which heterologous DNA is integrated into the genomic DNA at a homologous locus; homologously recombinant (HR) slow-growing mycobacteria having heterologous DNA integrated into their genomic DNA at a homologous locus; and mycobacterial DNA useful as a genetic marker.Type: GrantFiled: July 22, 1993Date of Patent: September 15, 1998Assignee: Whitehead Institute for Biomedical ResearchInventors: Anna Aldovini, Richard A. Young
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Patent number: 5776465Abstract: The present invention relates to recombinant mycobacteria, particularly recombinant M. bovis BCG, which express heterologous DNA encoding a product (protein or polypeptide) of interest, such a protein or polypeptide (e.g., an antigen) against which an immune response is desired, or a cytokine.Type: GrantFiled: June 5, 1995Date of Patent: July 7, 1998Assignees: Beth Israel Hospital Association, Whitehead Institute for Biomedical ResearchInventors: Michael A. O'Donnell, Rosemary B. Duda, William C. DeWolf, Anna Aldovini, Richard A. Young
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Patent number: 5591632Abstract: The present invention relates to recombinant mycobacteria, particularly recombinant M. bovis BCG, which express heterologous DNA encoding a product (protein or polypeptide) of interest, such a protein or polypeptide (e.g., an antigen) against which an immune response is desired or a cytokine.Type: GrantFiled: July 22, 1993Date of Patent: January 7, 1997Assignees: Beth Israel Hospital, Whitehead Institute For Biomedical ResearchInventors: Michael A. O'Donnell, Rosemary B. Duda, William C. DeWolf, Anna Aldovini, Richard A. Young