Patents by Inventor Anna Balanov

Anna Balanov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation and purification of gabapentin enacarbil
    Patent number: 8283487
    Abstract: Gabapentin enacarbil was prepared and purified from intermediates such as 1-haloalkyl carbamate or carbonate and diacid acetal skeleton. For example, a 1-haloalkyl carbonate or carbamate was prepared by combining a C1 to C10 alcohol or C1 to C10 primary amine, a solvent selected from the group consisting of: acetonitrile, C3 to C7 ketone, C5 to C10 ether, C2 to C7 ester, C5 to C10 hydrocarbon and a combination thereof; a 1-haloalkyl haloformate of the following formula: wherein each X is independently selected from Br, I, or Cl; R1 is alkyl or H; and a C6 to C21 tertiary amine.
    Type: Grant
    Filed: November 26, 2009
    Date of Patent: October 9, 2012
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Elena Ben Moha-Lerman, Tamar Nidam, Meital Cohen, Sharon Avhar-Maydan, Anna Balanov
  • Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
    Patent number: 8063211
    Abstract: The present invention provides rosuvastatin and intermediates thereof having a low level of alkylether impurity and processes for the preparation thereof.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: November 22, 2011
    Assignee: Teva Pharmaceutical Industries, Ltd.
    Inventors: Valerie Niddam-Hildesheim, Anna Balanov, Natalia Shenkar
  • Triol form of rosuvastatin and synthesis of rosuvastatin
    Patent number: 7851624
    Abstract: Provided is a rosuvastatin triol and its use as a reference standard for analysis of rosuvastatin. Also provided are methods for preparation of rosuvastatin.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: December 14, 2010
    Assignee: Teva Pharamaceutical Industries Ltd.
    Inventors: Valerie Niddam-Hildesheim, Anna Balanov, Irena Veinberg
  • DIASTEREOMERIC PURIFICATION OF ROSUVASTATIN
    Publication number: 20100197916
    Abstract: The invention relates to diastereomerically pure rosuvastatin and processes for preparing diastereomerically pure rosuvastatin and its intermediates.
    Type: Application
    Filed: February 2, 2010
    Publication date: August 5, 2010
    Inventors: Valerie NIDDAM-HILDESHEIM, Natalia SHENKAR, Kobi CHEN, Anna BALANOV
  • PROCESSES FOR THE PREPARATION AND PURIFICATION OF GABAPENTIN ENACARBIL
    Publication number: 20100160665
    Abstract: Gabapentin enacarbil was prepared and purified from intermediates such as 1-haloalkyl carbamate or carbonate and diacid acetal skeleton. For example, a 1-haloalkyl carbonate or carbamate was prepared by combining a C1 to C10 alcohol or C1 to C10 primary amine, a solvent selected from the group consisting of: acetonitrile, C3 to C7 ketone, C5 to C10 ether, C2 to C7 ester, C5 to C10 hydrocarbon and a combination thereof; a 1-haloalkyl haloformate of the following formula: wherein each X is independently selected from Br, I, or Cl; R1 is alkyl or H; and a C6 to C21 tertiary amine.
    Type: Application
    Filed: November 26, 2009
    Publication date: June 24, 2010
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: Elena Ben Moha-Lerman, Tamar Nidam, Meital Cohen, Sharon Avhar-Maydan, Anna Balanov
  • PREPARATION OF GABAPENTIN ENACARBIL INTERMEDIATE
    Publication number: 20100160666
    Abstract: Allyl 1 {[(?-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetate can be prepared by combining allyl 1-aminomethyl-1-cyclohexane acetate hydrochloride, a polar organic solvent, chloroethyl chloroformate, and an amine base or an inorganic base selected from a group consisting of carbonate and bicarbonate to provide a reaction mixture; and adding isobutyric acid to the reaction mixture. The product can be purified and/or converted to gabapentin enacarbil.
    Type: Application
    Filed: December 23, 2009
    Publication date: June 24, 2010
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: Elena BEN MOHA-LERMAN, Anna BALANOV, Miri ADLER
  • Crystalline ziprasidone HCl and processes for preparation thereof
    Patent number: 7678799
    Abstract: Provided is crystalline ziprasidone HCl and processes for preparation thereof.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: March 16, 2010
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Anna Balanov, Judith Aronhime, Boaz Gome, Tamas Koltai, Natalia Shenkar, Marioara Mendelovici, Ehud Amir
  • Processes for preparation of ziprasidone
    Patent number: 7667037
    Abstract: Provided are processes for preparing ziprasidone from CEI and BIPT.
    Type: Grant
    Filed: October 25, 2004
    Date of Patent: February 23, 2010
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Gideon Pilarsky, Natalia Shenkar, Marioara Mendelovici, Tamar Nidam, Anna Balanov
  • Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
    Patent number: 7612203
    Abstract: The present invention provides rosuvastatin and intermediates thereof having a low level of alkylether impurity and processes for the preparation thereof.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: November 3, 2009
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Valerie Niddam-Hildesheim, Anna Balanov, Natalia Shenkar
  • Diastereomeric purification of rosuvastatin
    Patent number: 7582759
    Abstract: The invention relates to diastereomerically pure rosuvastatin and processes for preparing diastereomerically pure rosuvastatin and its intermediates.
    Type: Grant
    Filed: September 12, 2006
    Date of Patent: September 1, 2009
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Valerie Niddam-Hildesheim, Natalia Shenkar, Kobi Chen, Anna Balanov
  • Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
    Publication number: 20090209567
    Abstract: The present invention provides rosuvastatin and intermediates thereof having a low level of alkylether impurity and processes for the preparation thereof.
    Type: Application
    Filed: March 11, 2009
    Publication date: August 20, 2009
    Inventors: Valerie Niddam-Hildesheim, Anna Balanov, Natalia Shenkar
  • Diastereomeric purification of rosuvastatin
    Publication number: 20090187026
    Abstract: The invention relates to diastereomerically pure rosuvastatin and processes for preparing diastereomerically pure rosuvastatin and its intermediates.
    Type: Application
    Filed: February 26, 2009
    Publication date: July 23, 2009
    Inventors: Valerie Niddam-Hildesheim, Natalia Shenkar, Kobi Chen, Anna Balanov
  • Rosuvastatin intermediates and their preparation
    Publication number: 20090069563
    Abstract: Provided are processes and intermediates for preparation of rosuvastatin.
    Type: Application
    Filed: July 14, 2008
    Publication date: March 12, 2009
    Inventors: Valerie Niddam-Hildesheim, Anna Balanov
  • Crystal forms of O-desmethylvenlafaxine succinate
    Publication number: 20090012182
    Abstract: Provided are crystalline forms of O-desmethylvenlafaxine succinate, methods for their preparation, and pharmaceutical composition thereof.
    Type: Application
    Filed: June 16, 2008
    Publication date: January 8, 2009
    Inventors: Alexandr Jegorov, Eli Lancry, Anna Balanov
  • Triol form of rosuvastatin and synthesis of rosuvastatin
    Publication number: 20080269270
    Abstract: Provided is a rosuvastatin triol and its use as a reference standard for analysis of rosuvastatin. Also provided are methods for preparation of rosuvastatin.
    Type: Application
    Filed: March 13, 2008
    Publication date: October 30, 2008
    Inventors: Valerie Niddam-Hildesheim, Anna Balanov, Irena Veinberg
  • Crystalline ziprasidone HCI and processes for preparation thereof
    Publication number: 20070238738
    Abstract: Provided is crystalline ziprasidone HCl and processes for preparation thereof.
    Type: Application
    Filed: May 16, 2007
    Publication date: October 11, 2007
    Inventors: Anna Balanov, Judith Aronhime, Boaz Gome, Tamas Koltai, Natalia Shenkar, Marioara Mendelovici, Ehud Amir
  • Diastereomeric purification of rosuvastatin
    Publication number: 20070191436
    Abstract: The invention relates to diastereomerically pure rosuvastatin and processes for preparing diastereomerically pure rosuvastatin and its intermediates.
    Type: Application
    Filed: September 12, 2006
    Publication date: August 16, 2007
    Inventors: Valerie Niddam-Hildesheim, Natalia Shenkar, Kobi Chen, Anna Balanov
  • Process for preparation of statins with high syn to anti ratio
    Publication number: 20070179166
    Abstract: Provided is a process for reduction of statin ketoesters and purification of diol esters of the statins through selective crystallization.
    Type: Application
    Filed: September 12, 2006
    Publication date: August 2, 2007
    Inventors: Valerie Niddam-Hildesheim, Anna Balanov, Kobi Chen
  • Preparation of rosuvastatin
    Publication number: 20070167625
    Abstract: Provided are processes for preparing intermediates of rosuvastatin and their use in preparation of rosuvastatin and rosuvastatin salts thereof.
    Type: Application
    Filed: October 4, 2006
    Publication date: July 19, 2007
    Inventors: Anna Balanov, Natalia Shenkar, Valerie Niddam-Hildesheim
  • Preparation of rosuvastatin
    Publication number: 20070037979
    Abstract: Provided are processes for preparing intermediates of rosuvastatin and their use in preparation of rosuvastatin and rosuvastatin salts thereof.
    Type: Application
    Filed: February 22, 2006
    Publication date: February 15, 2007
    Inventors: Valerie Niddam-Hildesheim, Anna Balanov, Natalia Shenkar, Shalom Shabat, Dalia Maidan-Hanoch