Abstract: The invention relates to polymeric compositions, nanoparticles and vaccines comprising polymeric compositions. The invention extends to medical uses of the polymeric compositions, nanoparticles and vaccines. The invention further extends to methods of producing the polymeric compositions and nanoparticles.

Abstract: The invention relates to vaccines, and in particular, to vaccines for preventing, treating or ameliorating coronavirus infections, such as severe acute respiratory syndrome coronavirus (SARS), SARS-CoV-2 and Middle East respiratory syndrome-related coronavirus (MERS). The invention is especially concerned with self-amplifying RNA replicons and genetic constructs or vectors encoding such RNA replicons, and their use in vaccine delivery for preventing infections of coronavirus. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

Abstract: The invention relates to RNA constructs encoding (i) at least one therapeutic biomolecule; and (ii) at least one innate inhibitor protein (IIP). The constructs are RNA replicons and saRNA molecules, and the invention includes genetic constructs or vectors encoding such RNA replicons. The invention extends to the use of such RNA constructs and replicons in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

Abstract: Described are drug delivery systems incorporating electrospun fibers that comprise and deliver physicochemically diverse drug compounds. Such fibers provide significant advantages in drug agent release, such as adaptability for solid dosage delivery to mucosal tissues. This is in addition to allowing for controlled drug release. Systems and methods for large-scale electrospinning productivity are described, including novel microarchitectures allowing for variable pharmacokinetics in drug release.

Abstract: Described are drug delivery systems incorporating electrospun fibers that comprise and deliver physicochemically diverse drug compounds. Such fibers provide significant advantages in drug agent release, such as adaptability for solid dosage delivery to mucosal tissues. This is in addition to allowing for controlled drug release. Systems and methods for large-scale electrospinning productivity are described, including novel microarchitectures allowing for variable pharmacokinetics in drug release.

Abstract: An incontinence device for wearing by a female is disclosed. A urine collection trough has an elongated open top end that is adapted to fit around the labia area of the female, encompassing her urethra. The trough has at least one non-rigid side wall and includes a drainage aperture in a lower portion thereof and a vaginal anchor means at an upper portion thereof. The vaginal anchor means is preferably a resilient protruding member fixed to the upper portion of the side wall of the trough. A drainage conduit is fixed at an upper end thereof to the drainage aperture that has at a lower end a valve means having an open position and a closed position. Preferably, the at least one side wall includes at least one attachment aperture therethrough, such that the device may be fixed to articles of clothing with straps, buttons, or the like.

Abstract: An incontinence device for wearing by a female is disclosed. A urine collection trough has an elongated open top end that is adapted to fit around the labia area of the female, encompassing her urethra. The trough has at least one non-rigid side wall and includes a drainage aperture in a lower portion thereof and a vaginal anchor means at an upper portion thereof. The vaginal anchor means is preferably a resilient protruding member fixed to the upper portion of the side wall of the trough. A drainage conduit is fixed at an upper end thereof to the drainage aperture that has at a lower end a valve means having an open position and a closed position. Preferably, the at least one side wall includes at least one attachment aperture therethrough, such that the device may be fixed to articles of clothing with straps, buttons, or the like.