Patents by Inventor Anna Bulek

Anna Bulek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Binding domain
    Patent number: 12325733
    Abstract: The present invention provides a variant antigen-binding domain which comprises at least one mutation in the VH domain compared to a reference antibody and which displays an increased affinity for TRBC2 over the reference antibody. It further provides an antibody, a chimeric antigen receptor (CAR), and a bispecific T-cell engager (BiTE), a cell which comprises said CAR, and a conjugate comprising said variant antigen-binding domain or said antibody. Additionally, it provides medical uses, diagnostic methods and methods of personalised medicine that exploit the products of the invention.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: June 10, 2025
    Assignee: AUTOLUS LIMITED
    Inventors: Anna Bulek, Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Mathieu Ferrari, Vania Baldan
  • BINDING DOMAIN
    Publication number: 20220041718
    Abstract: The present invention provides a variant antigen-binding domain which comprises at least one mutation in the VH domain compared to a reference antibody and which displays an increased affinity for TRBC2 over the reference antibody. It further provides an antibody, a chimeric antigen receptor (CAR), and a bispecific T-cell engager (BiTE), a cell which comprises said CAR, and a conjugate comprising said variant antigen-binding domain or said antibody. Additionally, it provides medical uses, diagnostic methods and methods of personalised medicine that exploit the products of the invention.
    Type: Application
    Filed: October 31, 2018
    Publication date: February 10, 2022
    Inventors: Anna Bulek, Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Mathieu Ferrari, Vania Baldan