Abstract: Described herein is a computer implemented method. The method includes a client application generating a document request and communicating the document request to a server system. The client application receives: document data including page data in respect of a plurality of pages of the document; recorded interaction data defining one or more interactive events that occurred during a recording of a presentation associated with the document; and media data including audio and/or video data recorded during the recording of the presentation. The client application replays the presentation by using the recorded interaction data to synchronise display of the pages with playback of the media data.

Abstract: Sounds produced by internal organs of the body can be used to monitor health conditions related to, for example, the heart and lungs. The present disclosure includes an electronic stethoscope that may be positioned by a user on locations of the body to record sounds from organs. The present disclosure also includes visual algorithms to guide positioning of the electronic stethoscope and audio diagnostic algorithms for providing analysis of recorded sounds.

Abstract: A system including a processor and memory may provide for automated support communications, such as communications with individuals who need assistance. Automated communications may use one or more factors to determine how to adjust communications according to the needs of a user. For example, automated communications may be adjusted based on, e.g., a keyword used by a user in the user's communications, or a location associated with the user's mobile device or user vehicle. Automated communications may be adjusted in timing, frequency, or content. One or more external events (e.g., phone call, dispatch request, additional automated communication) may be triggered based on the automated communications.

Abstract: CRISPR RNA-guided nucleases are routinely used for sequence-specific manipulation of DNA. While CRISPR-based DNA editing has become routine, analogous methods for editing RNA have yet to be established. Here we repurpose the type III-A CRISPR RNA-guided nuclease for sequence-specific cleavage of the SARS-COV-2 genome. The type III cleavage reaction is performed in vitro using purified viral RNA, resulting in sequence-specific excision of 6, 12, 18 or 24 nucleotides. Ligation of the cleavage products is facilitated by a DNA splint that bridges the excision and RNA ligase is used to link the RNA products before transfection into mammalian cells. The SARS-COV-2 RNA is infectious and standard plaque assays are used to recover viral clones. Collectively, this work demonstrates how type III CRISPR systems can be repurposed for sequence-specific editing of RNA viruses including SARS-COV-2 and more generally for gene therapy.

Abstract: An aerosol jet printer is used to deposit freestanding quantum dot matrices over optical elements such as LEDs or photodetectors. The printing process avoids the need for photolithographic masks while allowing variation in matrix height to be obtained. The matrices may be assembled with no or little binder material.

Abstract: A periprosthetic plate and method of use are disclosed that includes a proximal segment having a top portion and an end portion with at least two curved hooks that are capable of passing through a patient's abductor muscles and rest medially on a tip of a patient's greater trochanter (GT), wherein the proximal segment includes a plurality of recessed bone screw holes. A periprosthetic proximal femur plate is disclosed that includes a head portion having at least six first polyaxial screw holes and a shaft portion connected to the shaft portion having a plurality of rows of at least two second polyaxial screw holes located at an angle from the horizontal from about thirty degrees to about sixty degrees. A combination periprosthetic proximal femur plate and greater trochanter (GT) plate construct is disclosed that includes a greater trochanter (GT) plate located on top of the periprosthetic proximal femur plate.

Abstract: Disclosed is a method comprising obtaining at least one of: random-access channel information associated with at least one terminal device, load measurement information on a first set of candidate random-access channel transmission occasions, and interference measurement information on the first set of candidate random-access channel transmission occasions; determining, from the first set of candidate random-access channel transmission occasions, a set of random-access channel transmission occasions within a physical random-access channel slot based at least partly on the at least one of the random-access channel information, the load measurement information, and the interference measurement information; and indicating, to one or more first network nodes, at least one subset of the set of random-access channel transmission occasions.

Abstract: Described is a medical dressing that includes a backing layer, a body contact layer and a gel pad arranged between the backing layer and the body contact layer, wherein the backing layer and the body contact layer extend beyond a periphery of the gel pad to define a border portion around a contour of the pad, wherein the gel has a compressive strength of from 1 to 30 kPa at a strain of 25% and/or a compressive strength of from 5 to 70 kPa at a strain of 50%, as measured according to ASTM D3574-11, test C.

Abstract: Methods, systems, and devices for measuring cumulative stress of a user are described. A system may determine a first and second baseline heart rate variability (HRV) values of the user during periods that the user is awake and asleep, respectively. The system may then acquire physiological data from the user throughout a time interval, and determine a first set of HRV values during periods that the user is awake, and a second set of HRV values during periods that the user is asleep. The system may then determine a cumulative stress level of the user based on comparisons between the first set of HRV values and the first baseline HRV value, and between the second set of HRV values and the second baseline HRV value, where the cumulative stress level is associated with a total amount and/or trend of the user's stress level experienced throughout the time interval.

Abstract: Methods, systems, and devices for measuring resilience to stress are described. A system may acquire heart rate variability (HRV) data from a user via wearable device throughout multiple time intervals, where each time interval includes an awake interval that the user is awake and an asleep interval that the user is asleep. The system may determine a stress index and a recovery index associated with the awake interval of a respective time interval, and a sleep recovery index associated with the asleep interval of the respective time interval. The system may then determine a stress resilience metric of the user based on a weighted sum of the stress indices, recovery indices, and sleep recovery indices of the plurality of time intervals, where the stress resilience metric indicates a relative capability of the user to cope with and/or recover from stress.

Abstract: Systems and methods include providing a coated abrasive article with an enhanced anti-loading composition in a supersize coat. The anti-loading composition includes a mixture of a metal stearate, at least one performance component, and a polymeric binder composition.

Abstract: A lid assembly comprises a coupling ring, a lid and a connecting unit connecting the lid to the coupling ring. The lid comprises a cover wall configured to cover a pouring outlet and a sealing ring protruding away from the cover wall and configured to interact with a collar carrying the pouring outlet to seal the pouring outlet. The sealing ring comprises at least a first ring portion and a second ring portion. The first ring portion comprises a first end spaced apart from the cover wall and the second ring portion comprises a second end spaced apart from the cover wall. A first distance of the first end from the cover wall with respect to a normal axis of the cover wall is greater than a second distance of the second end from the cover wall with respect to the normal axis.

Abstract: Device information may be obtained using LoRaWAN communications. A device information request may be generated and transmitted by a user device and include request parameters such as a device type for which information is desired, a type of information requested, a geographic range for the request, and the like and/or combinations thereof. Device information requests may also be propagated or repeated by intermediary devices to achieve the desired request range. Accordingly, a recipient device of the original request may propagate or repeat, using LoRaWAN, a request signal if it determines that the request range has not been met. If the request range has been met, the recipient device might not repeat the request.

Abstract: A method of generating an aerosol comprising protonated nicotine, the method comprising the steps of: (i) providing a nicotine formulation comprising nicotine as free base; (ii) providing a carbon dioxide source capable of providing carbon dioxide in situ; (iii) vaporizing or aerosolizing the nicotine formulation; (iv) providing carbon dioxide from the carbon dioxide source, and (v) contacting the carbon dioxide with the vaporized or aerosolized nicotine formulation to thereby protonate nicotine free base and generate an aerosol comprising protonated nicotine.

Abstract: A computer-implemented method is for providing quantitative airway information. In an embodiment, the method includes receiving and/or determining first medical image data of an airway segment; applying a first trained function to the first medical image data, to generate output data; determining the at least one quantitative airway information of the airway segment based on the output data; and providing the at least one quantitative airway information.

Abstract: The present invention is directed to methods for the use of 5?-adenosine diphosphate ribose (ADPR), and compositions thereof, for treating, managing, or preventing RNA virus-related diseases or conditions, herpes virus related diseases or conditions, Sirtuin 6 (Sirt6)-related diseases or conditions, Pax6 related diseases or conditions, and p53 related diseases or conditions.

Abstract: Methods for treating Wilson Disease with bis-choline tetrathiomolybdate therapy are provided. The methods may include administering 15 mg or between 30 and 90 mg of bis-choline tetrathiomolybdate once daily to a patient exhibiting NCCcorrected, alanine aminotransferase (ALT), hemoglobin, platelets, or neutrophils levels meeting specified criteria. The methods may include modifying treatment by decreasing or increasing the daily dose of bis-choline tetrathiomolybdate or discontinuing treatment for a period of time.

Abstract: Partition damper seal configurations for segmented internal cooling hardware apparatus are disclosed. An example airfoil includes an outer wall having a first rib spaced apart from a second rib on a surface of the outer wall, and an inner wall surrounded by the outer wall, the inner wall having a third rib protruding from the inner wall towards the surface of the outer wall, an end of the third rib detachably coupled to a portion of the surface of the outer wall, the portion of the surface positioned between the first rib and the second rib, the third rib and at least one of the first rib or the second rib to at least partially seal a flow passage between the inner and outer walls.

Abstract: A registration device for the registration of facial topographic parameters is disclosed. The device comprises a base member, wherein the base member comprises a transverse section. The transverse section, in a central section thereof, comprises a coupling for rotationally immobile coupling to a referencing member. The base member further comprises two occlusal plane indicators extending in a posterior direction from the transverse section and is rotationally immobile connected to the transverse section. The occlusal plane indicators extend in a common plane. Two mandibular condyle indicator pointers are linked to the base member in a mobile linkage relationship allowing displacement of each mandibular condyle indicator pointer relative to the base member in a respective sagittal plane. A tragus indicator is pivotably coupled to each mandibular condyle indicator pointer. A method for using said device is further disclosed.