Abstract: Systems and methods relating to improving the experience of gig-economy workers are disclosed, with particular reference to gig-economy work involving vehicle use. Such systems and methods include automatically monitoring and evaluating activities such as driving during performance of gigs, as well as providing recommendations based thereupon. Transferable tokens may be used to apply information across various types of gig activities. Such a transferable token may represent one or more risk levels associated with a gig-economy worker to provide reputational information between gig-economy platforms or between types of gig-economy activities. Thus, the transferable token may enable a gig-economy worker to transfer high customer ratings across gig-economy platforms.

Abstract: A liquid pharmaceutical formulation comprising etoposide toniribate; a polysorbate; and ethanol. A method of preparing an infusion solution comprising diluting said liquid pharmaceutical formulation. Said composition or solution for use in treating cancer in a patient in need thereof.

Abstract: A head-mounted device includes a first device portion and a second device portion. A first coupler portion of the first device portion is connectable to a second coupler portion of the second device portion to define a connected position in which the first device portion is connected to the second device portion and a disconnected position in which the first device portion is disconnected from the second device portion. A second adjuster portion of the second device portion causes a first adjuster portion of the first device portion to move a first optical module and a second optical module in response to movement of the first device portion and the second device portion from the disconnected position to the connected position.

Abstract: The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

Abstract: The present invention relates to a composition comprising extract of poplar buds for use in the treatment of oropharyngeal cavity, urinary apparatus, digestive/excretory apparatus, skin affections and of bacterial infections.

Abstract: An automatic tattoo apparatus can be used to robotically apply tattoos. A customer can shop on an online tattoo marketplace to select designs created by various artists located anywhere. The online tattoo marketplace can process and manage payments, artist and/or customer profiles, bookings, tattoo design uploads, browsing and design selection, design changes, and/or perform other actions. The automatic tattoo device can apply tattoos precisely, quickly, and may with reduced pain. The tattoo apparatus can apply a wide range of different types of tattoos, including but not limited to micro tattoos, dotwork, blackwork tattoos, realism tattoos, fine-line tattoos, etc.

Abstract: The present invention relates to novel compounds of formula I: which have the properties of CDK8/19 inhibitors, to a pharmaceutical composition comprising said compounds, and to use thereof as a medicine for treating diseases and disorders.

Abstract: A process for preparing C5 aldehydes involves hydroformylation of butenes with synthesis gas in the presence of a homogeneous catalyst system and a solvent. It is a feature of the process that the aldehyde concentration in the reaction mixture is limited.

Abstract: The present disclosure relates to compositions and methods related to bicyclo[2.2.1] heptanamine-containing compounds and salts.

Abstract: A method for autonomous vehicle driver situational awareness recovery training includes receiving an input parameter; determining a simulation; receiving user performance data; and analyzing the user performance data to determine a driving competency score. A method for autonomous vehicle driver situational awareness recovery training includes receiving an input parameter; executing a simulation; and recording user performance data. A system includes a processor a display device; and a non-transitory computer-readable medium storing instructions that, when executed by the one or more processors, cause the system to receive an input parameter; execute a simulation; and record user performance data.

Abstract: A solder material comprising a solder alloy and a thermal conductivity modifying component. The solder material has a bulk thermal conductivity of between about 75 and about 150 W/m-K and is usable in enhancing the thermal conductivity of the solder, allowing for optimal heat transfer and reliability in electronic packaging applications.

Abstract: Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Abstract: Disclosed are methods of detecting the presence or absence of a genomic rearrangement in which a sample of tagged DNA molecules is divided into aliquots. The isolated molecules are linearly amplified with a set of primers that targeting loci of interest and comprise a rearrangement detection barcode, a sequencing adapter, and a non-nucleotide binding partner, thereby producing a first population of processed DNA, which is then captured on a solid support using binding to the non-nucleotide binding partner and amplified or eluted. A second aliquot is enriched for a second plurality of loci of interest, thereby producing a second population of processed DNA. At least a portion of the amplified and/or eluted first population of processed DNA and at least a portion of the second population of processed DNA are sequenced; and the presence or absence of genomic rearrangement(s) in the first population of processed DNA is detected.

Abstract: The invention relates to a hybrid tailgate for a vehicle, comprising a thermoplastic inner structure forming the carrier frame of the tailgate, and at least one composite reinforcement part to reinforce the carrier frame, wherein the composite reinforcement part is connected to the thermoplastic inner structure at a first surface, wherein the composite reinforcement part forms a continuous load path in the inner structure enclosing a tailgate window opening for a window glazing part of the tailgate. Furthermore, the invention relates to a vehicle comprising such a hybrid tailgate. Moreover, the invention relates to a method of manufacturing such a hybrid tailgate, the method comprising forming a composite laminate part into an insert; placing the insert in an injection molding tool; and over-molding the insert with polymer resin.

Abstract: The present disclosure provides a group of amidine analogs and their pharmaceutically acceptable salts that are useful for treating a bacterial or fungal infection. The infection may include those infections caused by gram negative bacteria, gram positive bacteria, or fungi. Compositions, methods of synthesizing the same and methods for treating bacterial or fungal infection are disclosed herein.

Abstract: The transport container for concentrated hydrogen peroxide comprises: a cuboid carrier frame; a liquid container provided inside the carrier frame (1) and frictionally connected thereto, said container having an internal volume of between 65 and 500 I and consisting of pure aluminium, chromium-nickel steel, a nickel-based alloy, or a steel coated with a polyolefin or clad on the inner face; a pressure equalisation device and a pressure relief valve, both of which are provided on the upper face of the liquid container; and at least one sealable opening of the liquid container for the charging and/or removal of hydrogen peroxide.

Abstract: The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.

Abstract: The invention relates to a cell culture carrier comprising a first channel and a reservoir, where the first channel and the reservoir are formed in the interior of the cell culture carrier, where the first channel has an inlet opening in an outer side of the cell culture carrier and an outlet opening in the outer side of the cell culture carrier, where the reservoir has at least two openings arranged next to one another, where the first channel is connected to the reservoir by the at least two openings, and where the reservoir is connected to the outer side of the cell culture carrier by no other channel.

Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, including administering to the subject a compound, wherein the compound comprises Aromoline, Obamegine, Berbamine or Bersavine.

Abstract: The present subject matter provides for albumin-binding prodrugs, maytansinoid-based compounds, and uses thereof.