Patents by Inventor Anna Cappa

Anna Cappa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indole derivatives as histone demethylase inhibitors
    Patent number: 10980777
    Abstract: The present application relates to compounds of formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: April 20, 2021
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Mario Varasi, Anna Cappa, Paola Vianello, Loris Moretti, Luca Sartori, Ciro Mercurio
  • Imidazoles as histone demethylase inhibitors
    Patent number: 10961255
    Abstract: The present invention relates to imidazole derivatives, wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: March 30, 2021
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Alessia Romussi, Anna Cappa, Paolo Trifiro′, Mario Varasi, Luca Sartori, Ciro Mercurio
  • IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20200299303
    Abstract: The present invention relates to imidazole derivatives, wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: December 20, 2019
    Publication date: September 24, 2020
    Inventors: Paola VIANELLO, Alessia ROMUSSI, Anna CAPPA, Paolo TRIFIRO', Mario VARASI, Luca SARTORI, Ciro MERCURIO
  • INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20200289463
    Abstract: The present application relates to compounds of formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: August 17, 2018
    Publication date: September 17, 2020
    Inventors: Mario VARASI, Anna CAPPA, Paola VIANELLO, Loris MORETTI, Luca SARTORI, Ciro MERCURIO
  • Imidazoles as histone demethylase inhibitors
    Patent number: 10562914
    Abstract: The present invention relates to imidazole derivatives of Formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: February 18, 2020
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Alessia Romussi, Anna Cappa, Paolo Trifiro', Mario Varasi, Luca Sartori, Ciro Mercurio
  • IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20190152987
    Abstract: The present invention relates to imidazole derivatives of Formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: May 18, 2017
    Publication date: May 23, 2019
    Inventors: Paola VIANELLO, Alessia ROMUSSI, Anna CAPPA, Paolo TRIFIRO', Mario VARASI, Luca SARTORI, Ciro MERCURIO
  • Cyclopropylamine compounds as histone demethylase inhibitors
    Patent number: 10233165
    Abstract: The present disclosure relates to cyclopropyl compounds of general formula (I), wherein R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: March 19, 2019
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Mario Varasi, Ciro Mercurio, Anna Cappa, Giuseppe Meroni, Manuela Villa, Antonello Mai, Sergio Valente
  • Thienopyrroles as histone demethylase inhibitors
    Patent number: 10183952
    Abstract: The present application relates to thienopyrrole derivatives, compounds of Formulas (I) and (Ia), wherein R, R1, R2 and R3 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy. The compounds of the application can be useful for inhibiting KDM1 and the prevention and/or treatment of cancer, infectious disease, or a disease characterized by aberration of cellular energy metabolism, e.g., obesity.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: January 22, 2019
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Luca Sartori, Mario Varasi, Ciro Mercurio, Elisa Zagarri, Anna Cappa, Alessia Romussi, Manuela Villa, Giuseppe Meroni, Loris Moretti
  • THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20170260197
    Abstract: The present application relates to thienopyrrole derivatives, compounds of Formulas (I) and (Ia), wherein R, R1, R2 and R3 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy. The compounds of the application can be useful for inhibiting KDM1 and the prevention and/or treatment of cancer, infectious disease, or a disease characterized by aberration of cellular energy metabolism, e.g., obesity.
    Type: Application
    Filed: September 4, 2015
    Publication date: September 14, 2017
    Inventors: Paola VIANELLO, Luca SARTORI, Mario VARASI, Ciro MERCURIO, Elisa ZAGARRI, Anna CAPPA, Alessia ROMUSSI, Manuela VILLA, Giuseppe MERONI, Loris MORETTI
  • CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20170190680
    Abstract: The present disclosure relates to cyclopropyl compounds of general formula (I), wherein R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: May 29, 2015
    Publication date: July 6, 2017
    Inventors: Paola VIANELLO, Mario VARASI, Ciro MERCURIO, Anna CAPPA, Giuseppe MERONI, Manuela VILLA, Antonello MAI, Sergio VALENTE
  • Acrylomido derivatives useful as inhibitors of the mitochondrial permeability transition
    Patent number: 8669261
    Abstract: Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R?, R?, W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: March 11, 2014
    Assignee: Congenia SLR
    Inventors: Daniele Fancelli, Mario Varasi, Simon Plyte, Marco Ballarini, Anna Cappa, Giacomo Carenzi, Saverio Minucci, Gilles Pain, Manuela Villa
  • ACRYLOMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION
    Publication number: 20130245019
    Abstract: Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R?, R?, W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.
    Type: Application
    Filed: April 30, 2013
    Publication date: September 19, 2013
    Applicant: CONGENIA SRL
    Inventors: Daniele Fancelli, Mario Varasi, Simon Plyte, Marco Ballarini, Anna Cappa, Giacomo Carenzi, Saverio Minucci, Gilles Pain, Manuela Villa
  • Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition
    Patent number: 8470831
    Abstract: Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R?, R?, W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: June 25, 2013
    Assignee: Cogenia SRL
    Inventors: Daniele Fancelli, Mario Varasi, Simon Plyte, Marco Ballarini, Anna Cappa, Giacomo Carenzi, Saverio Minucci, Gilles Pain, Manuela Villa
  • ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION
    Publication number: 20110195977
    Abstract: Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R?, R?, W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.
    Type: Application
    Filed: September 23, 2009
    Publication date: August 11, 2011
    Inventors: Daniele Fancelli, Varasi Mario, Simon Plyte, Marco Ballarini, Anna Cappa, Giacomo Carenzi, Saverio Minucci, Gilles Pain, Manuela Villa