Patents by Inventor Anna Chiu

Anna Chiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Capsid inhibitors for the treatment of HIV
    Patent number: 12594267
    Abstract: The present disclosure relates to compounds of Formula (Ia) and (Ib): or a pharmaceutically acceptable salt thereof, which are useful in the treatment of an HIV infection in heavily treatment-experienced patients with multidrug resistant HIV infection.
    Type: Grant
    Filed: February 27, 2024
    Date of Patent: April 7, 2026
    Assignee: Gilead Sciences, Inc.
    Inventors: Anna Chiu, Charles William Rowe, Scott P. Sellers
  • CAPSID INHIBITORS FOR THE PREVENTION OF HIV
    Publication number: 20250270192
    Abstract: The present disclosure provides methods of preventing HIV in a subject, comprising administering to the subject a therapeutically effective amount of a compounds of Formula (Ia) or (Ib): or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. Methods of reducing the risk of acquiring HIV (e.g., HIV-1 and/or HIV-2) are also provided.
    Type: Application
    Filed: May 13, 2025
    Publication date: August 28, 2025
    Inventors: Elena Bekerman, Wade S. Blair, Anna Chiu, Tomas Cihlar, Dana J. Levine, Winston C. Tse, Stephen R. Yant, Jim X. Zheng
  • CAPSID INHIBITORS FOR THE TREATMENT OF HIV
    Publication number: 20240316018
    Abstract: The present disclosure relates to compounds of Formula (Ia) and (Ib): or a pharmaceutically acceptable salt thereof, which are useful in the treatment of an HIV infection in heavily treatment-experienced patients with multidrug resistant HIV infection.
    Type: Application
    Filed: February 27, 2024
    Publication date: September 26, 2024
    Inventors: Laura Elizabeth Bauer, Anna Chiu, Eric M. Gorman, Andrew Stephen Mulato, Martin Sunkwang Rhee, Charles William Rowe, Scott P. Sellers, Dimitrios Stefanidis, Winston C. Tse, Stephen R. Yant, Dana J. Levine
  • Capsid inhibitors for the treatment of HIV
    Patent number: 11944611
    Abstract: The present disclosure relates to compounds of Formula (Ia) and (Ib): or a pharmaceutically acceptable salt thereof, which are useful in the treatment of an HIV infection in heavily treatment-experienced patients with multidrug resistant HIV infection.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: April 2, 2024
    Assignee: Gilead Sciences, Inc.
    Inventors: Laura Elizabeth Bauer, Anna Chiu, Eric M. Gorman, Andrew Stephen Mulato, Martin Sunkwang Rhee, Charles William Rowe, Scott P. Sellers, Dimitrios Stefanidis, Winston C. Tse, Stephen R. Yant, Dana J. Levine
  • CAPSID INHIBITORS FOR THE PREVENTION OF HIV
    Publication number: 20240051941
    Abstract: The present disclosure provides methods of preventing HIV in a subject, comprising administering to the subject a therapeutically effective amount of a compounds of Formula (Ia) or (Ib): or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. Methods of reducing the risk of acquiring HIV (e.g., HIV-1 and/or HIV-2) are also provided.
    Type: Application
    Filed: May 10, 2023
    Publication date: February 15, 2024
    Inventors: Elena Bekerman, Wade S. Blair, Anna Chiu, Tomas Cihlar, Dana J. Levine, Winston C. Tse, Stephen R. Yant, Jim X. Zheng
  • Capsid inhibitors for the prevention of HIV
    Patent number: 11807625
    Abstract: The present disclosure provides methods of preventing HIV in a subject, comprising administering to the subject a therapeutically effective amount of a compounds of Formula (Ia) or (Ib): or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. Methods of reducing the risk of acquiring HIV (e.g., HIV-1 and/or HIV-2) are also provided.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: November 7, 2023
    Assignee: Gilead Sciences, Inc.
    Inventors: Elena Bekerman, Wade S. Blair, Anna Chiu, Tomas Cihlar, Dana J. Levine, Winston C. Tse, Stephen R. Yant, Jim X. Zheng
  • Capsid inhibitors for the prevention of HIV
    Patent number: 11685728
    Abstract: The present disclosure provides methods of preventing HIV in a subject, comprising administering to the subject a therapeutically effective amount of a compounds of Formula (Ia) or (Ib): or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. Methods of reducing the risk of acquiring HIV (e.g., HIV-1 and/or HIV-2) are also provided.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: June 27, 2023
    Assignee: Gilead Sciences, Inc.
    Inventors: Elena Bekerman, Wade S. Blair, Anna Chiu, Tomas Cihlar, Dana J. Levine, Winston C. Tse, Stephen R. Yant, Jim X. Zheng
  • CAPSID INHIBITORS FOR THE PREVENTION OF HIV
    Publication number: 20210188815
    Abstract: The present disclosure provides methods of preventing HIV in a subject, comprising administering to the subject a therapeutically effective amount of a compounds of Formula (Ia) or (Ib): or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. Methods of reducing the risk of acquiring HIV (e.g., HIV-1 and/or HIV-2) are also provided.
    Type: Application
    Filed: November 25, 2020
    Publication date: June 24, 2021
    Applicant: Gilead Sciences, Inc.
    Inventors: Elena Bekerman, Wade S. Blair, Anna Chiu, Tomas Cihlar, Dana J. Levine, Winston C. Tse, Stephen R. Yant, Jim X. Zheng
  • Synthesis of polycyclic-carbamoylpyridone compounds
    Patent number: 10975096
    Abstract: Methods of making compounds of Formula I are disclosed:
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: April 13, 2021
    Assignee: Gilead Sciences, Inc.
    Inventors: Anna Chiu, John Enquist, Jr., Nolan Griggs, Christopher Hale, Norihiro Ikemoto, Katie Ann Keaton, Matt Kraft, Scott E. Lazerwith, Michel Leeman, Zhihui Peng, Kate Schrier, Jonathan Trinidad, Jochem Van Herpt, Andrew W. Waltman
  • Solid forms of an ASK1 inhibitor
    Patent number: 10946004
    Abstract: Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: March 16, 2021
    Assignee: Gilead Sciences, Inc.
    Inventors: Mark Andres, Brenda J. Burke Chan, Ernest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Gregory Notte, Valeriya N. Smolenskaya, Lok Him Yu
  • SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS
    Publication number: 20200223866
    Abstract: Methods of making compounds of Formula I are disclosed:
    Type: Application
    Filed: November 18, 2019
    Publication date: July 16, 2020
    Inventors: Anna Chiu, John Enquist, JR., Nolan Griggs, Christopher Hale, Norihiro Ikemoto, Katie Ann Keaton, Matt Kraft, Scott E. Lazerwith, Michel Leeman, Zhihui Peng, Kate Schrier, Jonathan Trinidad, Jochem Van Herpt, Andrew W. Waltman
  • SOLID FORMS OF AN ASK1 INHIBITOR
    Publication number: 20200061042
    Abstract: Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 27, 2020
    Inventors: Mark Andres, Brenda J. Burke Chan, Ernest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Gregory Notte, Valeriya Smolenskaya, Lok Him Yu
  • CAPSID INHIBITORS FOR THE TREATMENT OF HIV
    Publication number: 20200038389
    Abstract: The present disclosure relates to compounds of Formula (Ia) and (Ib): or a pharmaceutically acceptable salt thereof, which are useful in the treatment of an HIV infection in heavily treatment-experienced patients with multidrug resistant HIV infection.
    Type: Application
    Filed: July 15, 2019
    Publication date: February 6, 2020
    Applicant: Gilead Sciences, Inc.
    Inventors: Laura Elizabeth Bauer, Anna Chiu, Eric M. Gorman, Andrew Stephen Mulato, Martin Sunkwang Rhee, Charles William Rowe, Scott P. Sellers, Dimitrios Stefanidis, Winston C. Tse, Stephen R. Yant
  • SOLID FORMS OF AN ASK1 INHIBITOR
    Publication number: 20180243281
    Abstract: Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Application
    Filed: January 17, 2018
    Publication date: August 30, 2018
    Inventors: Mark Andres, Brenda J. Burke Chan, Eenest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Gregory Notte, Valeriya Smolenskaya, Lok Him Yu
  • SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS
    Publication number: 20180022757
    Abstract: Methods of making compounds of Formula I are disclosed:
    Type: Application
    Filed: June 30, 2017
    Publication date: January 25, 2018
    Inventors: Anna Chiu, John Enquist, JR., Nolan Griggs, Christopher Hale, Norihiro Ikemoto, Katie Ann Keaton, Matt Kraft, Scott E. Lazerwith, Michel Leeman, Zhihui Peng, Kate Schrier, Jonathan Trinidad, Jochem Van Herpt, Andrew W. Waltman
  • PROCESSES FOR PREPARING ASK1 INHIBITORS
    Publication number: 20170233350
    Abstract: The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.
    Type: Application
    Filed: January 23, 2017
    Publication date: August 17, 2017
    Inventors: Brandon Heath Brown, Brenda J. Burke Chan, Anna Chiu, Nolan Griggs, Lars V. Heumann, Stephen P. Lathrop, Gregory Notte, Troy Evan Reynolds, Keshab Sarma, David Allen Siler, Andrew S. Thompson, Tao Wang
  • Solid forms of an ASK1 inhibitor
    Patent number: 9643956
    Abstract: Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide(Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: May 9, 2017
    Assignee: Gilead Sciences, Inc.
    Inventors: Mark Andres, Brenda J. Burke Chan, Ernest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Gregory Notte, Valeriya Smolenskaya, Lok Him Yu
  • PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS
    Publication number: 20160332977
    Abstract: The present disclosure provides processes for the preparation of a compound of formula: which is a selective late sodium current inhibitor. The disclosure also provides compounds that are synthetic intermediates.
    Type: Application
    Filed: May 2, 2016
    Publication date: November 17, 2016
    Inventors: Anna Chiu, Yanshu Feng, Hanrong Gao, James A. Kerschen, John Reichwein, Keshab Sarma, Andrew S. Thompson, Xinjun Zhao
  • PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS
    Publication number: 20160332976
    Abstract: The present disclosure provides processes for the preparation of a compound of formula: which is a selective late sodium current inhibitor. The disclosure also provides compounds that are synthetic intermediates.
    Type: Application
    Filed: May 2, 2016
    Publication date: November 17, 2016
    Inventors: Anna Chiu, Yanshu Feng, Hanrong Gao, James A. Kerschen, John Reichwein, Keshab Sarma, Andrew S. Thompson, Xinjun Zhao
  • SOLID FORMS OF AN ASK1 INHIBITOR
    Publication number: 20160280683
    Abstract: Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Application
    Filed: December 22, 2015
    Publication date: September 29, 2016
    Applicant: Gilead Sciences, Inc.
    Inventors: Mark Andres, Brenda J. Burke Chan, Ernest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Valeriya Smolenskaya, Lok Him Yu