Patents by Inventor Anna Domogatskaya

Anna Domogatskaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MAINTENANCE OF DIFFERENTIATED CELLS WITH LAMININS
    Publication number: 20220041980
    Abstract: The present disclosure describes methods of maintaining the phenotype of differentiated cells. Generally, the natural environment of the body is replicated for the differentiated cell. The differentiated cell is plated on a cell culture substrate comprising a laminin, such as laminin-521 or laminin-511. The substrate may also contain a cadherin. This maintains the phenotype of the differentiated cell.
    Type: Application
    Filed: October 26, 2021
    Publication date: February 10, 2022
    Inventors: Karl Tryggvason, Karl Kristian Tryggvason, Anna Domogatskaya
  • Maintenance of differentiated cells with laminins
    Patent number: 11155781
    Abstract: The present disclosure describes methods of maintaining the phenotype of differentiated cells. Generally, the natural environment of the body is replicated for the differentiated cell. The differentiated cell is plated on a cell culture substrate comprising a laminin, such as laminin-521 or laminin-511. The substrate may also contain a cadherin. This maintains the phenotype of the differentiated cell.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: October 26, 2021
    Assignee: BIOLAMINA AB
    Inventors: Karl Tryggvason, Karl Kristian Tryggvason, Anna Domogatskaya
  • Composition and method for enabling proliferation of pluripotent human stem cells
    Patent number: 10829733
    Abstract: Compositions and processes for culturing human stem cells in vitro in an undifferentiated state are disclosed. In this regard, human embryonic stem cells proliferated and maintained their pluripotency when cultured on plates coated with recombinant laminin-10 (laminin-511).
    Type: Grant
    Filed: March 17, 2010
    Date of Patent: November 10, 2020
    Assignee: BIOLAMINA AB
    Inventors: Karl Tryggvason, Sergey Rodin, Anna Domogatskaya
  • MAINTENANCE OF DIFFERENTIATED CELLS WITH LAMININS
    Publication number: 20170067016
    Abstract: The present disclosure describes methods of maintaining the phenotype of differentiated cells. Generally, the natural environment of the body is replicated for the differentiated cell. The differentiated cell is plated on a cell culture substrate comprising a laminin, such as laminin-521 or laminin-511. The substrate may also contain a cadherin. This maintains the phenotype of the differentiated cell.
    Type: Application
    Filed: November 14, 2016
    Publication date: March 9, 2017
    Inventors: Karl Tryggvason, Karl Kristian Tryggvason, Anna Domogatskaya
  • Maintenance of differentiated cells with laminins
    Patent number: 9499794
    Abstract: The present disclosure describes methods of maintaining the phenotype of differentiated cells. Generally, the natural environment of the body is replicated for the differentiated cell. The differentiated cell is plated on a cell culture substrate comprising a laminin, such as laminin-521 or laminin-511. The substrate may also contain a cadherin. This maintains the phenotype of the differentiated cell.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: November 22, 2016
    Assignee: BioLamina AB
    Inventors: Karl Tryggvason, Karl Kristian Tryggvason, Anna Domogatskaya
  • Composition and method for enabling proliferation of pluripotent stem cells
    Patent number: 8951799
    Abstract: The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, that both maintain stem cells in vitro pluripotency and enable self-renewal. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or their functional domains, in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferated and maintained their pluripotency.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: February 10, 2015
    Assignee: BioLamina AB
    Inventors: Anna Domogatskaya, Sergey Rodin, Karl Tryggvason
  • Composition and method for enabling proliferation of pluripotent stem cells
    Patent number: 8722405
    Abstract: The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, for culturing stem cells in vitro in an undifferentiated state. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or laminin-5 (laminin-322), or their functional domains, the embryonic stem cells proliferated and maintained their pluripotency.
    Type: Grant
    Filed: January 4, 2008
    Date of Patent: May 13, 2014
    Inventors: Karl Tryggvason, Anna Domogatskaya, Sergey Rodin
  • MAINTENANCE OF DIFFERENTIATED CELLS WITH LAMININS
    Publication number: 20130280750
    Abstract: The present disclosure describes methods of maintaining the phenotype of differentiated cells. Generally, the natural environment of the body is replicated for the differentiated cell. The differentiated cell is plated on a cell culture substrate comprising a laminin, such as laminin-521 or laminin-511. The substrate may also contain a cadherin. This maintains the phenotype of the differentiated cell.
    Type: Application
    Filed: April 19, 2013
    Publication date: October 24, 2013
    Applicant: BIOLAMINA AB
    Inventors: Karl Tryggvason, Karl Kristian Tryggvason, Anna Domogatskaya
  • Composition and method for enabling proliferation of pluripotent stem cells
    Publication number: 20100323443
    Abstract: The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, that both maintain stem cells in vitro pluripotency and enable self-renewal. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or their functional domains, in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferated and maintained their pluripotency.
    Type: Application
    Filed: August 25, 2009
    Publication date: December 23, 2010
    Inventors: Anna Domogatskaya, Sergey Rodin, Karl Tryggvason
  • COMPOSITION AND METHOD FOR ENABLING PROLIFERATION OF PLURIPOTENT HUMAN STEM CELLS
    Publication number: 20100203635
    Abstract: Compositions and processes for culturing human stem cells in vitro in an undifferentiated state are disclosed. In this regard, human embryonic stem cells proliferated and maintained their pluripotency when cultured on plates coated with recombinant laminin-10 (laminin-511).
    Type: Application
    Filed: March 17, 2010
    Publication date: August 12, 2010
    Inventors: Karl Tryggvason, Sergey Rodin, Anna Domogatskaya
  • COMPOSITION AND METHOD FOR ENABLING PROLIFERATION OF PLURIPOTENT STEM CELLS
    Publication number: 20080213885
    Abstract: The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, for culturing stem cells in vitro in an undifferentiated state. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or laminin-5 (laminin-322), or their functional domains, the embryonic stem cells proliferated and maintained their pluripotency.
    Type: Application
    Filed: January 4, 2008
    Publication date: September 4, 2008
    Inventors: Karl Tryggvason, Anna Domogatskaya, Sergey Rodin