Abstract: A silicone prepolymer includes a reaction product of (a) a copolymerization product of a polymerization composition containing (i) an alkylacrylamide monomer, (ii) a hydroxyalkyl acrylate monomer, (iii) a non-bulky organosilicon-containing monomer having an ethylenically unsaturated reactive group, (iv) a bulky siloxane monomer having an ethylenically unsaturated reactive group and (v) one of a lifitegrast or a salt thereof-containing monomer having an ethylenically unsaturated reactive group and a releasable linking group or a lifitegrast or a salt thereof-containing polymer having an ethylenically unsaturated reactive group and a releasable linking group, with (b) a monomer having a reactive functionality complementary to the hydroxyl moiety of the hydroxyalkyl acrylate monomer and a polymerizable ethylenically unsaturated reactive group.

Abstract: A packaging system for the storage of an ophthalmic device is disclosed. The packaging system includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution that includes lifitegrast or salt thereof-containing hydrophilic polymer. The aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is sterilized.

Abstract: A surface modified ophthalmic device includes a silicone ophthalmic device having a hydrophilic surface coating attached to a surface of the silicone ophthalmic device by van der Waals dispersion forces, the hydrophilic surface coating comprising a copolymer comprising (i) monomeric units derived from an ethylenically unsaturated-containing monomer having ring-opening reactive functionalities, and (ii) monomeric units derived from a hydrophilic monomer having an ethylenically unsaturated reactive group.