Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: One variation of a method for monitoring manufacture of assembly units includes: receiving selection of a target location hypothesized by a user to contain an origin of a defect in assembly units of an assembly type; accessing a feature map linking non-visual manufacturing features to physical locations within the assembly type; for each assembly unit, accessing an inspection image of the assembly unit recorded by an optical inspection station during production of the assembly unit, projecting the target location onto the inspection image, detecting visual features proximal the target location within the inspection image, and aggregating non-visual manufacturing features associated with locations proximal the target location and representing manufacturing inputs into the assembly unit based on the feature map; and calculating correlations between visual and non-visual manufacturing features associated with locations proximal the target location and the defect for the set of assembly units.

Abstract: A computer-implemented electronic commons system for sharing information. The system including an electronic content management computer executing a stored program to implement the steps of (a) receiving electronic information content from users, the electronic information including identification of at least one author, (b) receiving instructions from users to organize multiple electronic information content into a handbook, (c) generating a handbook including the multiple electronic information content stored on a computer readable medium of the electronic content management computer based on the received instructions, (d) generating an attribution for the handbook, the attribution including the identifications of the authors of the constituent electronic information content in the handbook; and (e) displaying a representation of the attribution of the handbook.