Patents by Inventor Anna Gutowska
Anna Gutowska has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7963116Abstract: Compositions are disclosed for storing and releasing hydrogen and methods for preparing and using same. These hydrogen storage and releasing materials exhibit fast release rates at low release temperatures without unwanted side reactions, thus preserving desired levels of purity and enabling applications in combustion and fuel cell applications.Type: GrantFiled: May 4, 2009Date of Patent: June 21, 2011Assignee: Battelle Memorial InstituteInventors: S. Thomas Autrey, Abhijeet J. Karkamkar, Anna Gutowska, Liyu Li, Xiaohong S. Li, Yongsoon Shin
-
Publication number: 20090258215Abstract: Compositions are disclosed for storing and releasing hydrogen and methods for preparing and using same. These hydrogen storage and releasing materials exhibit fast release rates at low release temperatures without unwanted side reactions, thus preserving desired levels of purity and enabling applications in combustion and fuel cell applications.Type: ApplicationFiled: May 4, 2009Publication date: October 15, 2009Applicant: BATTELLE MEMORIAL INSTITUTEInventors: S. Thomas Autrey, Abhijeet J. Karkamkar, Anna Gutowska, Liyu Li, Xiaohong S. Li, Yongsoon Shin
-
Publication number: 20080112883Abstract: The invention relates to materials for storing and releasing bulk quantities of hydrogen and methods for preparing and using same. The materials exhibit fast release rates at low release temperatures are suitable as hydrogen sources for a variety of applications and devices.Type: ApplicationFiled: November 16, 2007Publication date: May 15, 2008Inventors: Thomas S. Autrey, Anna Gutowska, Yongsoon Shin, Liyu Li
-
Patent number: 7316788Abstract: The invention relates to materials for storing and releasing hydrogen and methods for preparing and using same. The materials exhibit fast release rates at low release temperatures and are suitable as fuel and/or hydrogen sources for a variety of applications such as automobile engines.Type: GrantFiled: February 12, 2004Date of Patent: January 8, 2008Assignee: Battelle Memorial InstituteInventors: Thomas S. Autrey, Anna Gutowska, Yongsoon Shin, Liyu Li
-
Patent number: 7087244Abstract: Disclosed is a thermogelling biodegradable aqueous polymer solution useful in providing a bioactive agent delivery system. A thermogelling biodegradable aqueous polymer solution may comprise a biocompatible block and a biodegradable polypeptide block, where the blocks are linked to form a polymer of a general structure comprising the formula of CnDm, wherein n is equal to or greater than 1, m is equal to or greater than 1, C is a biodegradable polypeptide block, and D is a biocompatible soluble polymer having a chain length such that if D is not biodegradable, D may be eliminated through a glomeruli filtration system.Type: GrantFiled: April 16, 2002Date of Patent: August 8, 2006Assignee: Battelle Memorial InstituteInventors: Byeongmoon Jeong, Anna Gutowska
-
Patent number: 7033571Abstract: A polymeric solution capable of gelling upon exposure to a critical minimum value of a plurality of environmental stimuli is disclosed. The polymeric solution may be an aqueous solution utilized in vivo and capable of having the gelation reversed if at least one of the stimuli fall below, or outside the range of, the critical minimum value. The aqueous polymeric solution can be used either in industrial or pharmaceutical environments. In the medical environment, the aqueous polymeric solution is provided with either a chemical or radioisotopic therapeutic agent for delivery to a specific body part. The primary advantage of the process is that exposure to one environmental stimuli alone will not cause gelation, thereby enabling the therapeutic agent to be conducted through the body for relatively long distances without gelation occurring.Type: GrantFiled: November 3, 2003Date of Patent: April 25, 2006Assignee: Battelle Memorial InstituteInventors: Anna Gutowska, Karol J. Krzyminski
-
Patent number: 6979464Abstract: The present invention is a thereapeutic agent carrier having a thermally reversible gel or geling copolymer that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum geling molecular weight cutoff and a therapeutic agent.Type: GrantFiled: December 11, 1998Date of Patent: December 27, 2005Assignee: Battelle Memorial InstituteInventor: Anna Gutowska
-
Publication number: 20050180916Abstract: The invention relates to materials for storing and releasing hydrogen and methods for preparing and using same. The materials exhibit fast release rates at low release temperatures and are suitable as fuel and/or hydrogen sources for a variety of applications such as automobile engines.Type: ApplicationFiled: February 12, 2004Publication date: August 18, 2005Inventors: Thomas Autrey, Anna Gutowska, Yongsoon Shin, Liyu Li
-
Patent number: 6869588Abstract: The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier.Type: GrantFiled: May 9, 2001Date of Patent: March 22, 2005Assignee: Battelle Memorial InstituteInventors: Richard E. Weller, Michael A. Lind, Darrell R. Fisher, Anna Gutowska, Allison A. Campbell
-
Patent number: 6841617Abstract: Disclosed is a thermogelling biodegradable aqueous polymer solution useful in providing a bioactive agent delivery system. The present invention provides a thermogelling biodegradable aqueous polymer solution with a polyethylene glycol (PEG) block and a biodegradable polyester block, where the blocks are linked to form a polymer of a general structure comprising the formula of An(B), where n is greater than 2 and A is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, B is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, and A is different from B.Type: GrantFiled: April 11, 2001Date of Patent: January 11, 2005Assignee: Battelle Memorial InstituteInventors: Byeong Moon Jeong, Anna Gutowska
-
Publication number: 20040228794Abstract: Disclosed herein are therapeutic agent carrier compositions that include a carrier comprised of a stimulus sensitive gel, fibrin, or combinations thereof, and a therapeutic agent such as an aqueous insoluble or confined radioisotope. Stimulus sensitive gels include thermally reversible stimulus-sensitive gels that are linear random copolymers of a [meth-]acrylamide derivative and a hydrophilic comonomer; thermogelling biodegradable polymers, which include biodegradable polymers including a linked polyethylene glycol (PEG) block and biodegradable polyester block; and enzymatically degradable polypeptide poylmers. In certain embodiments the therapeutic agent is a hydrothermally synthesized radioactive therapeutic agent, such a 90-yttrium phosphate colloid. Methods of making such carrier compositions and methods of using such carrier compositions to treat diseases such as cancer also are disclosed.Type: ApplicationFiled: February 19, 2004Publication date: November 18, 2004Applicant: Battelle Memorial InstituteInventors: Richard E. Weller, Darrell R. Fisher, Michael A. Lind, Allison A. Campbell, Anna Gutowska, Craig F. Habeger
-
Publication number: 20040096508Abstract: A polymeric solution capable of gelling upon exposure to a critical minimum value of a plurality of environmental stimuli is disclosed. The polymeric solution may be an aqueous solution utilized in vivo and capable of having the gelation reversed if at least one of the stimuli fall below, or outside the range of, the critical minimum value. The aqueous polymeric solution can be used either in industrial or pharmaceutical environments. In the medical environment, the aqueous polymeric solution is provided with either a chemical or radioisotopic therapeutic agent for delivery to a specific body part. The primary advantage of the process is that exposure to one environmental stimuli alone will not cause gelation, thereby enabling the therapeutic agent to be conducted through the body for relatively long distances without gelation occurring.Type: ApplicationFiled: November 3, 2003Publication date: May 20, 2004Applicant: Battelle Memorial InstituteInventors: Anna Gutowska, Karol J. Krzyminski
-
Publication number: 20040077780Abstract: Disclosed is a thermogelling biodegradable aqueous polymer solution useful in providing a bioactive agent delivery system. A thermogelling biodegradable aqueous polymer solution may comprise a biocompatible block and a biodegradable polypeptide block, where the blocks are linked to form a polymer of a general structure comprising the formula of CnDm, wherein n is equal to or greater than 1, m is equal to or greater than 1, C is a biodegradable polypeptide block, and D is a biocompatible soluble polymer having a chain length such that if D is not biodegradable, D may be eliminated through a glomeruli filtration system.Type: ApplicationFiled: April 16, 2002Publication date: April 22, 2004Applicant: Battelle Memorial InstituteInventors: Byeongmoon Jeong, Anna Gutowska
-
Patent number: 6660247Abstract: A polymeric solution capable of gelling upon exposure to a critical minimum value of a plurality of environmental stimuli is disclosed. The polymeric solution may be an aqueous solution utilized in vivo and capable of having the gelation reversed if at least one of the stimuli fall below, or outside the range of, the critical minimum value. The aqueous polymeric solution can be used either in industrial or pharmaceutical environments. In the medical environment, the aqueous polymeric solution is provided with either a chemical or radioisotopic therapeutic agent for delivery to a specific body part. The primary advantage of the process is that exposure to one environmental stimuli alone will not cause gelation, thereby enabling the therapeutic agent to be conducted through the body for relatively long distances without gelation occurring.Type: GrantFiled: June 23, 2000Date of Patent: December 9, 2003Assignee: Battelle Memorial InstituteInventors: Anna Gutowska, Karol J. Krzyminski
-
Publication number: 20030096010Abstract: The present invention is a thereapeutic agent carrier having a thermally reversible gel or geling copolymer that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum geling molecular weight cutoff and a therapeutic agent.Type: ApplicationFiled: December 11, 1998Publication date: May 22, 2003Inventor: ANNA GUTOWSKA
-
Publication number: 20020173586Abstract: Disclosed is a thermogelling biodegradable aqueous polymer solution useful in providing a bioactive agent delivery system. The present invention provides a thermogelling biodegradable aqueous polymer solution with a polyethylene glycol (PEG) block and a biodegradable polyester block, where the blocks are linked to form a polymer of a general structure comprising the formula of An(B), where n is greater than 2 and A is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, B is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, and A is different from B.Type: ApplicationFiled: April 11, 2001Publication date: November 21, 2002Inventors: Byeong Moon Jeong, Anna Gutowska
-
Publication number: 20020131935Abstract: The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier.Type: ApplicationFiled: November 26, 2001Publication date: September 19, 2002Inventors: Darrell R. Fisher, Richard E. Weller, Michael A. Lind, Anna Gutowska, Allison A. Campbell
-
Patent number: 6417247Abstract: The present invention provides a composition which comprises a polymer or polymer solution that forms a gel under controlled parameters and a ceramic matrix, the composition being fluid under non-physiological conditions and non fluid under physiological conditions. Polymers may be resorbable or non-resorbable, natural or synthetic and the solution aqueous or non-aqueous. Preferred polymers are poly saccharides, polyamides or polyamino acids, however any polymer or polymer solution that is biologically compatible and that is fluid under nonphysiological conditions and increases in viscosity under physiological conditions is suitable.Type: GrantFiled: May 15, 1998Date of Patent: July 9, 2002Inventors: Beth L. Armstrong, Allison A. Campbell, Anna Gutowska, Lin Song
-
Patent number: 6296831Abstract: The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier.Type: GrantFiled: April 10, 1998Date of Patent: October 2, 2001Assignee: Battelle Memorial InstituteInventors: Richard E. Weller, Michael A. Lind, Darrell R. Fisher, Anna Gutowska, Allison A. Campbell
-
Publication number: 20010024636Abstract: The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier.Type: ApplicationFiled: May 10, 2001Publication date: September 27, 2001Inventors: Richard E. Weller, Michael A. Lind, Darrell R. Fisher, Anna Gutowska, Allison A. Campbell