Patents by Inventor Anna Herland

Anna Herland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11402367
    Abstract: An organ-on-chip device for monitoring a biological function and including a membrane layer located at an interface region between a top microchannel and the a microchannel. The membrane includes a first type of cells forming a barrier between the top microchannel and the bottom microchannel. The device further includes a top layer having a first plurality of transendothelial electrical resistance (TEER) measurement electrodes for enabling direct monitoring of cell function and electrical activity of the first type of cells on the membrane. The device also has a multi-electrode array (MEA) layer with a second plurality of TEER measurement electrodes for enabling direct monitoring of cell function and electrical activity of a second type of cells on the MEA layer.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: August 2, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Ben M. Maoz, Anna Herland, Olivier F. Henry, Kevin K. Parker, Donald E. Ingber
  • Patent number: 11371022
    Abstract: The invention relates to a method of creating a human blood-brain barrier (BBB) model from the differentiation of human pluripotent stem cells (hPSCs), wherein the BBB exhibits sustained transendothelial electrical resistances (TEER) over 2000 ?·cm2 for at least 3 days after seeding.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: June 28, 2022
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Tae-Eun Park, Anna Herland, Edward Anthony Fitzgerald, Donald Elliot Ingber
  • Publication number: 20220089989
    Abstract: Systems and methods for producing and using a body having a first structure defining a first chamber, a second structure defining a second chamber, a membrane located at an interface region between the first chamber and the second chamber to separate the first chamber from the second chamber. The first chamber comprises a first permeable matrix disposed therein and the first permeable matrix comprises at least one or a plurality of lumens each extending therethrough, which is optionally lined with at least one layer of cells. The second chamber can comprise cells cultured therein. The systems and methods described herein can be used for various applications, including, e.g., growth and/or differentiation of primary cells, and/or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents). The systems and methods can also permit co-cultures of two or more different cell types.
    Type: Application
    Filed: December 2, 2021
    Publication date: March 24, 2022
    Inventors: Donald E. Ingber, Andries Van der Meer, Anna Herland
  • Publication number: 20200049689
    Abstract: An organ-on-chip device for monitoring a biological function and including a membrane layer located at an interface region between a top microchannel and the a microchannel. The membrane includes a first type of cells forming a barrier between the top microchannel and the bottom microchannel. The device further includes a top layer having a first plurality of transendothelial electrical resistance (TEER) measurement electrodes for enabling direct monitoring of cell function and electrical activity of the first type of cells on the membrane. The device also has a multi-electrode array (MEA) layer with a second plurality of TEER measurement electrodes for enabling direct monitoring of cell function and electrical activity of a second type of cells on the MEA layer.
    Type: Application
    Filed: February 26, 2018
    Publication date: February 13, 2020
    Inventors: Ben M. Maoz, Anna Herland, Olivier F. Henry, Kevin K. Parker, Donald E. Ingber
  • Publication number: 20190048316
    Abstract: The invention relates to a method of creating a human blood-brain barrier (BBB) model from the differentiation of human pluripotent stem cells (hPSCs), wherein the BBB exhibits sustained transendothelial electrical resistances (TEER) over 2000 ?·cm2 for at least 3 days after seeding.
    Type: Application
    Filed: February 16, 2017
    Publication date: February 14, 2019
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Tae-Eun PARK, Anna HERLAND, Edward Anthony FITZGERALD, Donald Elliot INGBER
  • Publication number: 20180298317
    Abstract: Systems and methods for producing and using a body having a first structure defining a first chamber, a second structure defining a second chamber, a membrane located at an interface region between the first chamber and the second chamber to separate the first chamber from the second chamber. The first chamber comprises a first permeable matrix disposed therein and the first permeable matrix comprises at least one or a plurality of lumens each extending therethrough, which is optionally lined with at least one layer of cells. The second chamber can comprise cells cultured therein. The systems and methods described herein can be used for various applications, including, e.g., growth and/or differentiation of primary cells, and/or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents). The systems and methods can also permit co-cultures of two or more different cell types.
    Type: Application
    Filed: April 25, 2016
    Publication date: October 18, 2018
    Inventors: Donald E. INGBER, Andries VAN DER MEER, Anna HERLAND
  • Publication number: 20170158997
    Abstract: Provided herein relates to devices for simulating a function of a tissue and methods of using the same. In some embodiments, the devices can be used to simulate a function of a human liver tissue. In some embodiments, the devices can be used to simulate a function of a dog liver tissue. Endothelial cell culture media for long-term culture of endothelial cells are also described herein.
    Type: Application
    Filed: December 2, 2016
    Publication date: June 8, 2017
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Donald E. Ingber, Geraldine A. Hamilton, Kyung-Jin Jang, Suzzette Haney, Payal Patel, Anna Herland, Joshua Isaac Nielsen Resnikoff
  • Patent number: 8710246
    Abstract: A compound is provided of the formula wherein each u is independently selected from 0 and 1; each R2 and R4 is independently selected from carboxy, carboxyalkyl, alkoxycarbonylalkyl, aminoalkyl, (amino)(carboxy)alkyl and (amino)(carboxy)alkoxy; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: April 29, 2014
    Assignee: Biochromix Newco AB
    Inventors: Peter Åsberg, Leif Johansson, Anna Herland, Andreas Åslund, Peter Konradsson
  • Publication number: 20120157516
    Abstract: The present invention relates to novel substituted thiophene derivatives useful in therapy of diseases related to misfolded and aggregated proteins.
    Type: Application
    Filed: October 19, 2009
    Publication date: June 21, 2012
    Inventors: Peter Åsberg, Leif Johansson, Anna Herland, Andreas Åslund, Peter Konradsson
  • Patent number: 7867718
    Abstract: The invention relates to methods for measuring conformational changes and self-assembly/aggregation of proteins, especially the formation of amyloid fibrils, using conjugated polyelectrolytes. The conjugate polyelectrolyte is exposed to the protein whereby the conjugated polyelectrolyte and the protein of interest interact, and a change of a property of the polyelectrolyte in response to conformational changes of the protein is observed. The detected change is used to determine different conformations of the protein, especially the formation of amyloid fibrils.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: January 11, 2011
    Assignee: BioChromix AB
    Inventors: Peter Nilsson, Anna Herland, Per Hammarstrom, Peter Asberg, Olle Inganas
  • Publication number: 20080038751
    Abstract: The invention relates to methods for measuring conformational changes and self-assembly/aggregation of proteins, especially the formation of amyloid fibrils, using conjugated polyelectrolytes. The conjugate polyelectrolyte is exposed to the protein whereby the conjugated polyelectrolyte and the protein of interest interact, and a change of a property of the polyelectrolyte in response to conformational changes of the protein is observed. The detected change is used to determine different conformations of the protein, especially the formation of amyloid fibrils.
    Type: Application
    Filed: February 22, 2005
    Publication date: February 14, 2008
    Inventors: Peter Asberg, Peter Nilsson, Olle Inganas, Anna Herland, Per Hammarstrom