Patents by Inventor Anna Huttenlocher

Anna Huttenlocher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to inhibit neutrophil recruitment to damaged tissue using myeloid-derived growth factor
    Patent number: 11980654
    Abstract: A method to inhibit neutrophil recruitment to damaged tissue, thereby inhibiting inflammation in a subject. The method includes administering to an anti-inflammatory amount of a myeloid-derived growth factor (“MYDGF”). Also disclosed are corresponding pharmaceutical compositions of matter containing the MYDGF.
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: May 14, 2024
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Anna Huttenlocher, Deane Mosher, Valeriu Bortnov, David Bennin, Ruth Anne Houseright, Frances M Smith
  • SIRPalpha Inhibited Macrophages and Neutrophils and Uses Thereof
    Publication number: 20230338420
    Abstract: The disclosure generally relates to methods for producing macrophages and neutrophils serum-free and feeder-free conditions from SIRP? inhibited pluripotent stem cells. The disclosure further relates to SIRP? inhibited macrophages and neutrophils and uses thereof.
    Type: Application
    Filed: February 6, 2023
    Publication date: October 26, 2023
    Inventors: Igor Slukvin, Aditi Majumder, Portia Smith, Anna Huttenlocher, David Bennin
  • Protein Tyrosine Phosphatase 1B Inhibited Neutrophils, Neutrophil-Dendritic Cell Hybrids and Uses Thereof
    Publication number: 20230323301
    Abstract: This disclosure provides methods for producing neutrophils under serum-free and feeder-free conditions from protein tyrosine phosphatase 1B (PTP1b)-inhibited pluripotent stem cells. The disclosure further provides PTP1b inhibited neutrophils and uses thereof. Also disclosed are methods for producing human neutrophil-DC hybrid cells and human neutrophil-DC hybrid cells produced thereby.
    Type: Application
    Filed: April 6, 2023
    Publication date: October 12, 2023
    Inventors: Anna Huttenlocher, Igor Slukvin, Morgan Giese, Ho Sun Jung, David Bennin
  • METHOD TO INHIBIT NEUTROPHIL RECRUITMENT TO DAMAGED TISSUE USING MYELOID-DERIVED GROWTH FACTOR
    Publication number: 20220168390
    Abstract: A method to inhibit neutrophil recruitment to damaged tissue, thereby inhibiting inflammation in a subject. The method includes administering to an anti-inflammatory amount of a myeloid-derived growth factor (“MYDGF”). Also disclosed are corresponding pharmaceutical compositions of matter containing the MYDGF.
    Type: Application
    Filed: September 22, 2021
    Publication date: June 2, 2022
    Inventors: Anna Huttenlocher, Deane Mosher, Valeriu Bortnov, David Bennin
  • GENERATION OF FUNCTIONAL NEUTROPHILS AND MACROPHAGES FROM INDUCED PLURIPOTENT STEM CELLS IN CHEMICALLY DEFINED CONDITIONS USING TRANSIENT EXPRESSION OF ETV2
    Publication number: 20200385676
    Abstract: The present invention provides methods of producing in vitro derived neutrophils or macrophages in xenogen- and serum-free conditions from pluripotent stem cells and in vitro derived populations of neutrophils and macrophages. Methods of treatment using in vitro derived neutrophils or macrophages are also contemplated.
    Type: Application
    Filed: June 5, 2020
    Publication date: December 10, 2020
    Inventors: Igor I. Slukvin, Vera Sergeyevna Brok Volchanskaya, Kran Suknuntha, Anna Huttenlocher, David Alfred Bennin, Lucas Klemm