Abstract: Provided are an antibody or antigen binding fragment thereof that binds to CD70 for use in treating a myeloid malignancy in a human subject, who is resistant to BCL-2 inhibitor treatment and methods of treating a myeloid malignancy in a subject, said method comprising (a) selecting a human subject having a myeloid malignancy that has a reduced sensitivity or is refractory to a BCL-2 inhibitor; and (b) administering to the subject an antibody or antigen binding fragment thereof that binds to CD70. In certain embodiments, the myeloid malignancy is acute myeloid leukemia (AML). In certain embodiments, the antibody that binds to CD70 is cusatuzumab. In certain embodiments, a BCL-2 inhibitor is co-administered with the antibody or antigen binding fragment thereof that binds to CD70. In certain embodiments, the BCL-2 inhibitor is venetoclax.

Abstract: An ankle foot orthosis having a lower leg element, a foot element, and a first energy storing unit being adapted such that moving the foot element relative to the lower leg element in dorsiflexion direction from a position in which the amount of energy stored in the first energy storing unit is minimal loads the first energy storing unit with energy. The first energy storing unit is adapted such that the amount of energy stored in the first energy storing unit is increased by moving the foot element relative to the lower leg element in a plantar flexion direction from a first position in which the amount of energy stored in the first energy storing unit is minimal into a second position and moving the foot element relative to the lower leg element in dorsiflexion direction from the second position back into the first position.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for updating a molecular database. In one aspect, a method includes: receiving data representing a sequence of molecular nucleotides, where the data specifies a base of each molecular nucleotide and synthetic modifications to one or more components of one or more molecular nucleotides in the sequence; generating a user interface presentation that presents: i) for each base in the sequence, a base character that represents the base of the molecular nucleotide, and ii) for each of the one or more molecular nucleotides having one or more components that are synthetically modified, a group of symbols adjacent to the base character that represents the base of the molecular nucleotide, where each symbol in the group of symbols represents a respective synthetic modification; and providing the user interface presentation to a user device for display to a user.

Abstract: The present invention relates to an electrical plug contact, comprising—a line having an insulating section, a fastening section, and a contacting section,—a line shield that at least partially encloses the line,—a connector that electrically contacts the line at the end of the line in the contacting section,—an insulating retainer, which locks with the connector and which is arranged in the contacting and fastening sections, for insulating the connector from an electrically conductive housing, and—a secondary locking sleeve that at least partially surrounds the line in the fastening section and that can be fastened to the line, wherein shielding transfer means are provided in order to transfer the shielding from the line shield to the housing.

Abstract: The present invention relates to an electrical plug contact, comprising—a line having an insulating scction, a fastening section, and a contacting section,—a line shield that at least partially encloses the line,—a connector that electrically contacts the line at the end of the line in the contacting section,—an insulating retainer, which locks with the connector and which is arranged in the contacting and fastening sections, for insulating the connector from an electrically conductive housing, and—a secondary locking sleeve that at least partially surrounds the line in the fastening section and that can be fastened to the line, wherein shielding transfer means are provided in order to transfer the shielding from the line shield to the housing.