Abstract: Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.

Abstract: The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

Abstract: A respiratory system provides bi-level pressure using a dual pressure device in fluid communication with a source of breathable gas and a patient interface. The dual pressure device includes a pipe submerged in a liquid in a container, and a float disposed along the pipe. The float cyclically moves up and down the pipe between a lower position and an upper position as the floats buoyancy changes. The floats position along the pipe causes the gas pressure level to alternate between a baseline pressure level and a peak pressure level by selectively blocking and unblocking an opening in the pipe, and selectively capturing and releasing gas from the float, with the maximum gas pressure being limited by the setting on a pressure relief valve.

Abstract: Compounds having the structure of Formula (I): and pharmaceutically acceptable salts thereof, wherein X1, R1, R2, R3, R4, R5 and R6 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.

Abstract: A respiratory system provides bi-level pressure using a dual pressure device in fluid communication with a source of breathable gas and a patient interface. The dual pressure device includes a pipe submerged in a liquid in a container, and a float disposed along the pipe. The float cyclically moves up and down the pipe between a lower position and an upper position as the floats buoyancy changes. The floats position along the pipe causes the gas pressure level to alternate between a baseline pressure level and a peak pressure level by selectively blocking and unblocking an opening in the pipe, and selectively capturing and releasing gas from the float, with the maximum gas pressure being limited by the setting on a pressure relief valve.