Patents by Inventor Anna Jurcakova

Anna Jurcakova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 3, 14.beta.-dihydroxy-17-normorphinan
    Patent number: 5504208
    Abstract: Process for the preparation of 3,14.beta.-dihydroxy-17-normorphinan ##STR1## A suitable economic process for the preparation of 3,14.beta.-dihydroxy-17-normorphinan of a general formula (I) is being solved, which is a key intermediate of a semisynthetic synthesis of an effective analgesic of Butorphanol from thebaine.Synthesis includes a two step N-demethylation, and concerted dephenoxylation of 4-phenoxy-14.beta.-hydroxy-3-methoxymorphinan in the first step by means of a chloroformate, then, in the second step, by means of sodium action in a liquid ammonia, and by means of the following O-demethylation under action of a complex of aluminium chloride - dialkylsulfide.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: April 2, 1996
    Assignee: Galena a.s.
    Inventors: Roman Sobotik, Petr Bulej, Tomas Kolasin, Alexandr Jegorov, Petr Sedmera, Ales Husek, Anna Jurcakova