Patents by Inventor Anna Kruczynski

Anna Kruczynski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VINFLUNINE AND PD1 AND/OR PDL1 INHIBITOR AS PHARMACEUTICAL COMBINATION
    Publication number: 20190307741
    Abstract: The present invention relates to a pharmaceutical combination comprising: (a) vinflunine or a pharmaceutically acceptable salt thereof, and (b) at least one PD1-inhibitor and/or at least one PD-L1-inhibitor or pharmaceutically acceptable salt thereof. Such a pharmaceutical combination is useful as a drug, notably in the treatment of a proliferative disease, such as cancer.
    Type: Application
    Filed: July 6, 2017
    Publication date: October 10, 2019
    Applicant: PIERRE FABRE MEDICAMENT
    Inventors: Anna KRUCZYNSKI, Isabelle VANDENBERGHE, Pierre FERRE
  • Derivatives of macrocyclic N-aryl-tricyclopyrimidine-2-amine polyethers as inhibitors of FTL3 and JAK
    Patent number: 10323043
    Abstract: The present invention relates to a compound with the following formula (I): (I) or a salt and/or a pharmaceutically acceptable solvate thereof, in particular for use as a drug, in particular in the treatment of cancer, as well as to the pharmaceutical compositions that contain same and to the methods for preparing same.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: June 18, 2019
    Assignee: PIERRE FABRE MEDICAMENT
    Inventors: El Bachir Kaloun, Serge Grisoni, Anna Kruczynski, Philippe Schmitt
  • Isoquinolinone derivatives useful in the treatment of cancer
    Patent number: 9944641
    Abstract: The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, notably for use as a drug, notably in the treatment of cancer, as well as pharmaceutical compositions containing such a compound and processes to prepare such a compound.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: April 17, 2018
    Assignee: PIERRE FABRE MEDICAMENT
    Inventors: El Bachir Kaloun, Philippe Schmitt, Anna Kruczynski
  • DERIVATIVES OF MACROCYCLIC N-ARYL-TRICYCLOPYRIMIDINE-2-AMINE POLYETHERS AS INHIBITORS OF FTL3 AND JAK
    Publication number: 20170283432
    Abstract: The present invention relates to a compound with the following formula (I): (I) or a salt and/or a pharmaceutically acceptable solvate thereof, in particular for use as a drug, in particular in the treatment of cancer, as well as to the pharmaceutical compositions that contain same and to the methods for preparing same.
    Type: Application
    Filed: September 2, 2015
    Publication date: October 5, 2017
    Applicant: PIERRE FABRE MEDICAMENT
    Inventors: El Bachir KALOUN, Serge GRISONI, Anna KRUCZYNSKI, Philippe SCHMITT
  • ISOQUINOLINONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER
    Publication number: 20170240544
    Abstract: The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, notably for use as a drug, notably in the treatment of cancer, as well as pharmaceutical compositions containing such a compound and processes to prepare such a compound.
    Type: Application
    Filed: September 2, 2015
    Publication date: August 24, 2017
    Applicant: PIERRE FABRE MEDICAMENT
    Inventors: El Bachir KALOUN, Philippe SCHMITT, Anna KRUCZYNSKI
  • Derivatives of azaindazole or diazaindazole type for treating a cancer overexpressing Trk
    Patent number: 9428510
    Abstract: The present invention relates to a compound of following formula (I) or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of same in any proportions, such as a mixture of enantiomers, notably a racemic mixture, as well as pharmaceutical composition comprising such a compound, for use in the treatment of a cancer associated with the overexpression of at least one Trk protein.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: August 30, 2016
    Assignee: PIERRE FABRE MEDICAMENT
    Inventors: Anna Kruczynski, Laurent Creancier, El Bachir Kaloun, Karim Bedjeguelal, Rémi Rabot
  • (Poly) aminoacetamide derivatives of epipodophyllotoxin their process of preparation and their applications in therapeutics as anticancer agents
    Patent number: 9403840
    Abstract: The present invention relates to novel podophyllotoxin derivatives substituted in the 4-position by a substituted (poly)aminoalkylaminoacetamide chain, to their process of preparation and to their use as medicament as anticancer agents.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: August 2, 2016
    Assignee: PIERRE FABRE MEDICAMENT
    Inventors: Thierry Imbert, Yves Guminski, Jean-Marc Barret, Anna Kruczynski
  • (POLY) AMINOACETAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN THEIR PROCESS OF PREPARATION AND THEIR APPLICATIONS IN THERAPEUTICS AS ANTICANCER AGENTS
    Publication number: 20150368258
    Abstract: The present invention relates to novel podophyllotoxin derivatives substituted in the 4-position by a substituted (poly)aminoalkylaminoacetamide chain, to their process of preparation and to their use as medicament as anticancer agents.
    Type: Application
    Filed: September 1, 2015
    Publication date: December 24, 2015
    Applicant: PIERRE FABRE MEDICAMENT
    Inventors: Thierry IMBERT, Yves GUMINSKI, Jean-Marc BARRET, Anna KRUCZYNSKI
  • (Poly) aminoacetamide derivatives of epipodophyllotoxin their process of preparation and their applications in therapeutics as anticancer agents
    Patent number: 9216989
    Abstract: The present invention relates to novel podophyllotoxin derivatives substituted in the 4-position by a substituted (poly)aminoalkylaminoacetamide chain, to their process of preparation and to their use as medicament as anticancer agents.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: December 22, 2015
    Assignee: PIERRE FABRE MEDICAMENT
    Inventors: Thierry Imbert, Yves Guminski, Jean-Marc Barret, Anna Kruczynski
  • DERIVATIVES OF AZAINDAZOLE OR DIAZAINDAZOLE TYPE FOR TREATING A CANCER OVEREXPRESSING Trk
    Publication number: 20150266880
    Abstract: The present invention relates to a compound of following formula (I) or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of same in any proportions, such as a mixture of enantiomers, notably a racemic mixture, as well as pharmaceutical composition comprising such a compound, for use in the treatment of a cancer associated with the overexpression of at least one Trk protein.
    Type: Application
    Filed: July 29, 2013
    Publication date: September 24, 2015
    Applicant: PIERRE FABRE MEDICAMENT
    Inventors: Anna Kruczynski, Laurent Creancier, El Bachir Kaloun, Karim Bedjeguelal, Rémi Rabot
  • Substituted pyrazolo[3,4-b]pyridines as medicaments
    Patent number: 8883821
    Abstract: The present invention relates to a compound of following formula (I): or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of same in any proportions, such as a mixture of enantiomers, notably a racemic mixture; as well as to the use of same as a drug, notably intended for the treatment of cancer, inflammation and neurodegenerative diseases such as Alzheimer's disease; to the use of same as a kinase inhibitor; to the pharmaceutical compositions comprising same; and to methods for the preparation of same.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: November 11, 2014
    Assignee: Pierre Fabre Medicament
    Inventors: El Bachir Kaloun, Karim Bedjeguelal, Rémi Rabot, Anna Kruczynski, Philippe Schmitt, Michel Perez, Nicolas Rahier
  • (Poly)Aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents
    Patent number: 8492567
    Abstract: The present invention relates to new derivatives of epipodophyllotoxin 4-substituted with an optionally substituted (poly)aminoalkylaminoalkylamide, or alkyl-urea or alkyl-sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: July 23, 2013
    Assignee: Pierre Fabre Medicament
    Inventors: Thierry Imbert, Yves Guminski, Jean-Marc Barret, Anna Kruczynski
  • DERIVATIVES OF AZAINDAZOLE OR DIAZAINDAZOLE TYPE AS MEDICAMENT
    Publication number: 20130172360
    Abstract: The present invention relates to a compound of following formula (I): or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of same in any proportions, such as a mixture of enantiomers, notably a racemic mixture; as well as to the use of same as a drug, notably intended for the treatment of cancer, inflammation and neurodegenerative diseases such as Alzheimer's disease; to the use of same as a kinase inhibitor; to the pharmaceutical compositions comprising same; and to methods for the preparation of same.
    Type: Application
    Filed: January 27, 2012
    Publication date: July 4, 2013
    Applicant: PIERRE FABRE MEDICAMENT
    Inventors: El Bachir Kaloun, Karim Bedjeguelal, Rémi Rabot, Anna Kruczynski, Philippe Schmitt, Michel Perez, Nicolas Rahier
  • NEW (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA, OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, A PROCESS FOR PREPARING THEM, AND APPLICATION THEREOF IN THERAPY AS ANTICANCER AGENTS
    Publication number: 20120283281
    Abstract: The present invention relates to new derivatives of epipodophyllotoxin 4-substituted with an optionally substituted (poly)aminoalkylaminoalkylamide, or alkyl-urea or alkyl-sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent.
    Type: Application
    Filed: July 17, 2012
    Publication date: November 8, 2012
    Inventors: Thierry IMBERT, Yves GUMINSKI, Jean-Marc BARRET, Anna KRUCZYNSKI
  • (Poly) aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents
    Patent number: 8288567
    Abstract: The present invention relates to new derivatives of epipodophyllotoxin 4-substituted with an optionally substituted (poly)aminoalkylaminoalkylamidc, or alkyl-urea or alkyl-sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent. Formula (1) wherein: —R represents hydrogen or C1-4alkyl, —A represents CO(CH2)n or CONH(CH2)n where n=2, 3, 4, or 5, —R1 and R2 are as described herein.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: October 16, 2012
    Assignee: Pierre Fabre Medicament
    Inventors: Thierry Imbert, Yves Guminski, Jean-Marc Barret, Anna Kruczynski
  • (POLY) AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA, OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, A PROCESS FOR PREPARING THEM, AND APPLICATION THEREOF IN THERAPY AS ANTICANCER AGENTS
    Publication number: 20110172257
    Abstract: The present invention relates to new derivatives of epipodophyllotoxin 4-substituted with an optionally substituted (poly)aminoalkylaminoalkylamide, or alkyl-urea or alkyl-sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent. Formula (1) wherein: —R represents hydrogen or C1-4alkyl, —A represents CO(CH2)n or CONH(CH2)n where n=2, 3, 4, or 5, —R1 and R2 are as described herein.
    Type: Application
    Filed: August 19, 2009
    Publication date: July 14, 2011
    Inventors: Thierry Imbert, Yves Guminski, Jean-Marc Barret, Anna Kruczynski
  • (POLY) AMINOACETAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN THEIR PROCESS OF PREPARATION AND THEIR APPLICATIONS IN THERAPEUTICS AS ANTICANCER AGENTS
    Publication number: 20110053967
    Abstract: The present invention relates to novel podophyllotoxin derivatives substituted in the 4-position by a substituted (poly)aminoalkylaminoacetamide chain, to their process of preparation and to their use as medicament as anticancer agents.
    Type: Application
    Filed: November 10, 2010
    Publication date: March 3, 2011
    Inventors: Thierry IMBERT, Yves GUMINSKI, Jean-Marc BARRET, Anna KRUCZYNSKI
  • (Poly)aminoacetamide derivatives of epipodophyllotoxin their process of preparation and their applications in therapeutics as anticancer agents
    Patent number: 7846926
    Abstract: The present invention relates to novel podophyllotoxin derivatives substituted in the 4-position by a substituted (poly)aminoalkylaminoacetamide chain, to their process of preparation and to their use as medicament as anticancer agents.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: December 7, 2010
    Assignee: Pierre Fabre Medicament
    Inventors: Thierry Imbert, Yves Guminski, Jean-Marc Barret, Anna Kruczynski
  • (Poly) aminoacetamide derivatives of epipodophyllotoxin their process of preparation and their applications in therapeutics as anticancer agents
    Publication number: 20090170843
    Abstract: The present invention relates to novel podophyllotoxin derivatives substituted in the 4-position by a substituted (poly)aminoalkylaminoacetamide chain, to their process of preparation and to their use as medicament as anticancer agents.
    Type: Application
    Filed: April 14, 2005
    Publication date: July 2, 2009
    Inventors: Thierry Imbert, Yves Guminski, Jean-Marc Barret, Anna Kruczynski
  • Crystalline compound of 4'-demethyl-4'-phosphate-2", 3"-bispentafluorophenoxy-acetyl-4", 6"-ethylidene-beta-d-epipodophyllotoxin glucoside either in its free form or solvated with ethanol
    Publication number: 20070042971
    Abstract: The invention relates to a crystalline compound of 4?-demethyl-4?-phosphate-2?,3?-bispentafluorophenoxyacetyl-4?,6?-ethylidene-?-D-epipodophyllotoxin glucoside in its free form or solvated with ethanol, advantageously provided in the form of a hemiethanolate solvate. The invention also relates to a method for preparing these compounds and to their use as an anticancer drug.
    Type: Application
    Filed: September 16, 2004
    Publication date: February 22, 2007
    Applicant: Pierre Fabre Medicament
    Inventors: Yves Guminski, Thierry Imbert, Anna Kruczynski