Patents by Inventor Anna-Lena BOLENDER

Anna-Lena BOLENDER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LARGE MOLECULE UNSPECIFIC CLEARANCE ASSAY
    Publication number: 20230194547
    Abstract: Herein is reported a method for determining non-specific clearance of an antibody comprising the steps of incubating the antibody, which is conjugated to a pH-sensitive fluorescent dye, with primary human endothelial cells, and determining the fluorescence intensity of the primary human endothelial cells, whereby an increase of the fluorescence intensity of the primary human endothelial cells above background level is indicative for non-specific clearance of the antibody.
    Type: Application
    Filed: October 7, 2022
    Publication date: June 22, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Anna-Lena BOLENDER, Martina DUSCHMALE, Lisa EBELER, Johannes FRAIDLING, Thomas KRAFT