Patents by Inventor Anna-Lena GLASS

Anna-Lena GLASS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF A CHIRAL TRIOL
    Publication number: 20240018076
    Abstract: The invention comprises a process for the preparation of a chiral triol of formula I wherein, R1 is hydrogen or halogen by way of an asymmetric hydrogenation of a ketone compound of formula IIa wherein, R1 is hydrogen or halogen and R2 is C1-6-alkyl; with hydrogen in the presence of an iridium spiro-pyridylamidophosphine catalyst (Ir-SpiroPAP catalyst). The chiral triols of formula I are versatile building blocks for the preparation of various pharmaceutically active drug substances such as for instance for statins.
    Type: Application
    Filed: July 12, 2023
    Publication date: January 18, 2024
    Applicants: Hoffmann-La Roche Inc., Genentech, Inc.
    Inventors: Anna-Lena GLASS, Allen Yu HONG, Kurt PUENTENER