Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: Systems and methods are provided for dynamically modeling and depicting overall emissions of the aviation industry and changes thereto when taking into account, for example, traffic growth and introduction of sustainability strategies, such as new and/or improved technologies, an increase in operational efficiency, and carbon offsets. Using the dynamic tool described herein, users can define scenarios on how to reduce emissions through the introduction of different sustainability strategies, both statically and over time, analyze the impact of those strategies on emissions, and understand the dependencies between select strategies.

Abstract: The present invention relates to methods of producing industrial products from plant lipids, particularly from vegetative parts of plants. In particular, the present invention provides oil products such as biofuel, and processes for producing these products, as well as plants having an increased level medium chain fatty acids such as lauric acid and myristic acid. In one particular embodiment, the present invention relates to combinations of modifications in a fatty acid thioesterase and one or more acyltransferases. In an embodiment, the present invention relates to a process for extracting lipids. In another embodiment, the lipid is converted to one or more hydrocarbon products in harvested plant vegetative parts to produce alkyl esters of the fatty acids which are suitable for use as a renewable biofuel.

Abstract: Embodiments of the present disclosure can include a method for convective intracellular delivery including providing cells and molecules to a microchannel having compressive surfaces, wherein the compressive surfaces define compression gaps having a height of from 20 and 80% of the average cell diameter, and a plurality of relaxation spaces disposed between the compressive surfaces, flowing the cell medium through the microchannel, wherein as the cell medium flows through the microchannel, the plurality of cells undergo a convective intracellular delivery process comprising: compressing the plurality of cells, wherein the compressing causes the plurality of cells to undergo a loss in intracellular volume Vloss, and passing the plurality of cells to a first relaxation space, wherein the plurality of cells undergo a gain in volume Vgain and absorb a portion of the plurality of molecules.

Abstract: Embodiments of the present disclosure can include a method for convective intracellular delivery including providing cells and molecules to a microchannel having compressive surfaces, wherein the compressive surfaces define compression gaps having a height of from 20 and 80% of the average cell diameter; and a plurality of relaxation spaces disposed between the compressive surfaces; flowing the cell medium through the microchannel, wherein as the cell medium flows through the microchannel, the plurality of cells undergo a convective intracellular delivery process comprising: compressing the plurality of cells, wherein the compressing causes the plurality of cells to undergo a loss in intracellular volume (Vloss); and passing the plurality of cells to a first relaxation space, wherein the plurality of cells undergo a gain in volume (Vgain) and absorb a portion of the plurality of molecules.

Abstract: A self-expandable stent (1) formed of a flexible, part-tubular body (2), anchoring portions (3) extending from each end of the body (2) and an array (4) of holes or perforations (40, 41, 42) through the body (2) and anchoring portions (3). The body (2) includes an open side (20) and a pair of axial edges (21) extending along a longitudinal axis (L) of the stent (1). The body (2) also includes a central portion (5) and a pair of axial edge portions (6) joining the central portion (5) to the axial edges (21). The central portion (5) of the body (2) is invertible from a relaxed, part-tubular condition to a flexed, inverted part-tubular condition in which the axial edges (21) overlap or converge toward one another for insertion and release in a lumen (TR, TET) to expand, bear against and support a wall of the lumen (TR, TET).

Abstract: Embodiments relate generally to absorbing elements in respiratory face masks. Applicants have developed a structure for respiratory masks that can both absorb moisture from the face (such as perspiration, as well as from condensed moisture in the breath), and maintain a low breath resistance (won't increase the breath resistance significantly). The structure may comprise an annular structure added to the respiratory masks for moisture management, wherein the annular structure comprises moisture absorbent materials. This structure may also be known as an absorbing element operable to absorb moisture effectively, provide a respiratory mask with improved moisture control characteristics, reduce fogging of a face shield or eyeglasses of the wearer, and reduce the amount of uncomfortable moisture buildup on the face of the wearer.

Abstract: Embodiments relate generally to absorbing elements in respiratory face masks. Applicants have developed a structure for respiratory masks that can both absorb moisture from the face (such as perspiration, as well as from condensed moisture in the breath), and maintain a low breath resistance (won't increase the breath resistance significantly). The structure may comprise an annular structure added to the respiratory masks for moisture management, wherein the annular structure comprises moisture absorbent materials. This structure may also be known as an absorbing element operable to absorb moisture effectively, provide a respiratory mask with improved moisture control characteristics, reduce fogging of a face shield or eyeglasses of the wearer, and reduce the amount of uncomfortable moisture buildup on the face of the wearer.

Abstract: An emoticon input method and device are provided. The method includes: when an emoticon input instruction is received, displaying emoticon combinations on an emoticon page according to recorded frequencies of use of the emoticon combinations, where each of the emoticon combinations including at least two emoticons; and according to a received emoticon combination selection instruction, inputting an emoticon combination corresponding to the emoticon combination selection instruction.

Abstract: A self-expandable stent (1) formed of a flexible, part-tubular body (2), anchoring portions (3) extending from each end of the body (2) and an array (4) of holes or perforations (40, 41, 42) through the body (2) and anchoring portions (3). The body (2) includes an open side (20) and a pair of axial edges (21) extending along a longitudinal axis (L) of the stent (1). The body (2) also includes a central portion (5) and a pair of axial edge portions (6) joining the central portion (5) to the axial edges (21). The central portion (5) of the body (2) is invertible from a relaxed, part-tubular condition to a flexed, inverted part-tubular condition in which the axial edges (21) overlap or converge toward one another for insertion and release in a lumen (TR, TET) to expand, bear against and support a wall of the lumen (TR, TET).

Abstract: Embodiments of the present disclosure can include a method for convective intracellular delivery including providing cells and molecules to a microchannel having compressive surfaces, wherein the compressive surfaces define compression gaps having a height of from 20 and 80% of the average cell diameter; and a plurality of relaxation spaces disposed between the compressive surfaces; flowing the cell medium through the microchannel, wherein as the cell medium flows through the microchannel, the plurality of cells undergo a convective intracellular delivery process comprising: compressing the plurality of cells, wherein the compressing causes the plurality of cells to undergo a loss in intracellular volume (Vloss); and passing the plurality of cells to a first relaxation space, wherein the plurality of cells undergo a gain in volume (Vgain) and absorb a portion of the plurality of molecules.

Abstract: A water purification system (100) including an inlet (110) configured to accept a flow of water (105) is provided. The system (100) includes a KDF filtration stage (120) fluidly connected to the inlet (110) and including a metal alloy including elemental copper and elemental zinc. The system (100) includes a reverse osmosis stage (140) fluidly connected to the KDF stage (120). The system (100) also includes an outlet (150) fluidly connected to the reverse osmosis stage (140) and configured to output a flow of purified water (155). The reverse osmosis stage (140) is downstream of the KDF stage (120). A method of purifying water is also provided.

Abstract: A reverse osmosis membrane (100) and a method of processing the same are described herein. One device includes a hollow fiber membrane material (102), and a polyamide material (104) on a surface of the hollow fiber membrane material(1 02) in a lumen (106) side of the hollow fiber membrane material (102). One method includes forming the hollow fiber membrane material (102), and forming the polyamide material (104) on the surface of the hollow fiber membrane material (102) in the lumen (106) side of the hollow fiber membrane material (102).

Abstract: Embodiments relate to systems and methods for providing airflow within a particulate matter sensor. A particulate matter sensor may comprise an air duct, a light source configured to pass light through the air duct, a extender connected to the light source configured to dissipate thermal energy generated by the light source, and to generate a updraft of airflow into the air duct, a photodetector located in the air duct, and a computing device coupled to the photodetector. The computing device has a processor and a memory storing instructions which, when executed by the processor, determines a mass concentration of particles in the air duct based on an output of the photodetector.

Abstract: An emoticon input method and device are provided. The method includes: when an emoticon input instruction is received, displaying emoticon combinations on an emoticon page according to recorded frequencies of use of the emoticon combinations, where each of the emoticon combinations including at least two emoticons; and according to a received emoticon combination selection instruction, inputting an emoticon combination corresponding to the emoticon combination selection instruction.

Abstract: Embodiments relate generally to absorbing elements in respiratory face masks. Applicants have developed a structure for respiratory masks that can both absorb moisture from the face (such as perspiration, as well as from condensed moisture in the breath), and maintain a low breath resistance (won't increase the breath resistance significantly). The structure may comprise an annular structure added to the respiratory masks for moisture management, wherein the annular structure comprises moisture absorbent materials. This structure may also be known as an absorbing element operable to absorb moisture effectively, provide a respiratory mask with improved moisture control characteristics, reduce fogging of a face shield or eyeglasses of the wearer, and reduce the amount of uncomfortable moisture buildup on the face of the wearer.

Abstract: Embodiments relate to systems and methods for providing airflow within a particulate matter sensor. A particulate matter sensor may comprise an air duct, a light source configured to pass light through the air duct, a extender connected to the light source configured to dissipate thermal energy generated by the light source, and to generate a updraft of airflow into the air duct, a photodetector located in the air duct, and a computing device coupled to the photodetector. The computing device has a processor and a memory storing instructions which, when executed by the processor, determines a mass concentration of particles in the air duct based on an output of the photodetector.

Abstract: An apparatus for inspecting a light transmissive optical component comprises an image capturing module arranged on a first side of a support configured to hold a light transmissive optical component while it is being inspected. One or more first illuminating means are arranged on the first side of the support and adapted to illuminate from a first side of a light transmissive optical component held by the support. One or more second illuminating means are arranged on a second side of the support and adapted to illuminate from a second side of the light transmissive optical component held by the support, the second side of the support opposing the first side of said support.

Abstract: A cloud based method and system for the backup and recovery of a computer or computer system is provided with the ability to determine a network model that emulates the network environment of the computer or computer system being backed up. Should a disaster event occur, the network model is used by a disaster recovery computer to construct a virtual network environment that emulates the network environment of the backed up computer or computer system.

Abstract: This disclosure relates to creating a resource and for configuring a resource (314) in cloud computing. A processor receives a source resource identifier of a source resource (304) in a source cloud (302) and sends a request to create a target resource (314) in the target cloud (312). The processor then receives a target resource identifier of the created target resource (314) and stores an association (500) between the target resource identifier (504) and the source resource identifier (502). Using the stored association allows to determine a target resource identifier for a resource identifier and therefore configuration of target resources, where the configuration depends on target resource identifiers.