Patents by Inventor Anna Luisa Colombo

Anna Luisa Colombo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing doxorubicin
    Patent number: 6210930
    Abstract: The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism is mutated. The mutated gene is preferably dnrU and/or dnrX.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: April 3, 2001
    Assignee: Pharmacia & Upjohn, S.P.A.
    Inventors: Silvia Filippini, Natalia Lomovskaya, Leonid Fonstein, Anna Luisa Colombo, C. Richard Hutchinson, Sharee L. Otten, Umberto Breme
  • Anthracycline glycosides
    Patent number: 6187758
    Abstract: An anthracycline glycoside of formula I wherein R is one of the two following residues: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: February 13, 2001
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Cinzia Portello, Emanuele Arlandini, Umberto Breme, Anna Luisa Colombo, Giuliano Franchi, Giuliano Oronzo, Marco Tató, Luisa Garofano, Marina Ciomei
  • Process for preparing daunorubicin and doxorubicin
    Patent number: 5989869
    Abstract: The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism involved in the glycosylation of daunorubicin to acid-sensitive, baumycin-like compounds is inactivated.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: November 23, 1999
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Silvia Filippini, Natalia Lomovskaya, Leonid Fonstein, Anna Luisa Colombo, C. Richard Hutchinson
  • Process for preparing doxorubicin
    Patent number: 5955319
    Abstract: The present invention concerns a process for improving doxorubicin production by means of a recombinant Streptomyces peucetius strain bearing a mutation in the gene dnrU coding for a protein involved in the metabolism of daunorubicin.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: September 21, 1999
    Assignee: Pharmacia & Upjohn, S.p.A.
    Inventors: Silvia Filippini, Umberto Breme, Anna Luisa Colombo, Natasha Lomovskaya, Leonid Fonstein, Sharee Otten, Charles R. Hutchinson
  • Daunorubin 14-hydroxylase
    Patent number: 5786190
    Abstract: The ability to convert daunorubicin to doxorubicin can be conferred on a host cell by transformation with a recombinant vector comprising DNA encoding daunorubicin 14-hydroxylase. The host cell can then be used to produce doxorubicin.
    Type: Grant
    Filed: December 3, 1996
    Date of Patent: July 28, 1998
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Augusto Solari Inventi, Umberto Breme, Anna Luisa Colombo, Charles Richard Hutchinson, Sharee Otten, Claudio Scotti
  • DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin
    Patent number: 5695966
    Abstract: The ability to convert daunorubicin to doxorubicin can be conferred on a host cell by transformation with a recombinant vector comprising DNA encoding daunorubicin 14-hydroxylase. The host cell can then be used to produce doxorubicin.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: December 9, 1997
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Augusto Solari Inventi, Umberto Breme, Anna Luisa Colombo, Charles Richard Hutchinson, Sharee Otten, Claudio Scotti
  • Isolation and characterisation of genes resistant to anthracycline antibiotics
    Patent number: 5665564
    Abstract: Doxorubicin resistance can be conferred on a host by transforming the host with a recombinant vector comprising a DNA having the configuration of restriction sites shown in FIGS. 1 or 2 of the accompanying drawings or a restriction fragment derived therefrom containing a gene coding for doxorubicin resistance.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: September 9, 1997
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Marinella Caruso, Anna Luisa Colombo, Luisa Garofano, Francesca Torti, Guiseppe Zanella
  • Process for preparing daunorubicin
    Patent number: 5652125
    Abstract: The ability to improve the conversion of .epsilon.-rhodomycinone to daunorubicin can be conferred on a bacterial host transformed with a recombinant vector comprising a DNA coding for an appropriate protein useful for that conversion. Furthermore, the bacterial host may have a mutation that blocks the function of a gene of daunorubicin metabolism.
    Type: Grant
    Filed: June 10, 1996
    Date of Patent: July 29, 1997
    Assignee: Pharmacia S.p.A.
    Inventors: Claudio Scotti, Charles Richard Hutchinson, Anna Luisa Colombo, Silvia Filippini