Patents by Inventor Anna M. Krichevsky

Anna M. Krichevsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genome Editing for Treating Glioblastoma
    Publication number: 20190010496
    Abstract: A method of treating a subject who has a glioma, e.g., astrocytoma, oligodendroglioma, or glioblastoma multiforme tumor, the method comprising administering to the subject a therapeutically effective amount of a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) microRNA-10b (miR-10b) editing complex comprising a CRISPR Associated Protein 9 (Cas9) and at least one guide RNA targeting a sequence encoding miR-10b.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 10, 2019
    Inventors: Anna M. Krichevsky, Rachid El-Fatimy, Erik J. Uhlmann
  • Diagnosing and monitoring CNS malignancies using microRNA
    Patent number: 10100367
    Abstract: The use of specific microRNAs (miRNAs) present in CSF as biomarkers for particular brain malignancies and disease activity.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: October 16, 2018
    Assignees: The Regents of the University of California, The Brigham and Women's Hospital, Inc.
    Inventors: Anna M. Krichevsky, Nadiya Teplyuk, Santosh Kesari, Brit Mollenhauer
  • Targeting microRNA-26a/b for the treatment of neurodegenerative disease
    Patent number: 9951331
    Abstract: Methods for treating a neurodegenerative disorder associated with aggregation of tau protein in the brain of a subject, comprising administering to the subject a therapeutically effective amount of one or more inhibitory nucleic acids targeting microRNA-26a, microRNA-26b, or both microRNA-26a and 26b.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: April 24, 2018
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventor: Anna M. Krichevsky
  • Diagnosing and Monitoring CNS Malignancies Using MicroRNA
    Publication number: 20170342505
    Abstract: The use of specific microRNAs (miRNAs) present in CSF as biomarkers for particular brain malignancies and disease activity.
    Type: Application
    Filed: June 13, 2017
    Publication date: November 30, 2017
    Inventors: Anna M. Krichevsky, Nadiya Teplyuk, Santosh Kesari, Brit Mollenhauer
  • Targeting microRNA-26a/b for the Treatment of Neurodegenerative Disease
    Publication number: 20160272968
    Abstract: Methods for treating a neurodegenerative disorder associated with aggregation of tau protein in the brain of a subject, comprising administering to the subject a therapeutically effective amount of one or more inhibitory nucleic acids targeting microRNA-26a, microRNA-26b, or both microRNA-26a and 26b.
    Type: Application
    Filed: September 10, 2014
    Publication date: September 22, 2016
    Inventor: Anna M. Krichevsky
  • Diagnosing and Monitoring CNS Malignancies Using MicroRNA
    Publication number: 20160115549
    Abstract: The use of specific microRNAs (miRNAs) present in CSF as biomarkers for particular brain malignancies and disease activity.
    Type: Application
    Filed: October 5, 2015
    Publication date: April 28, 2016
    Inventors: Anna M. Krichevsky, Nadiya Teplyuk, Santosh Kesari, Brit Mollenhauer
  • Diagnosing and monitoring CNS malignancies using MicroRNA
    Patent number: 9150928
    Abstract: The use of specific microRNAs (miRNAs) present in CSF as biomarkers for particular brain malignancies and disease activity.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: October 6, 2015
    Assignees: The Brigham and Women's Hospital, Inc., The Regents of the University of California
    Inventors: Anna M. Krichevsky, Nadiya Teplyuk, Brit Mollenhauer, Santosh Kesari
  • Treatment of inflammatory diseases using miR-124
    Patent number: 8962583
    Abstract: Methods of treating, reducing the risk of developing, or delaying the onset of an inflammatory disease are disclosed. The methods involved providing a subject with or at risk of developing an inflammatory disease and administering to the subject an effective amount of a first therapeutic composition comprising miR-124. Further provided are methods of diagnosing a subject with or at risk of developing an inflammatory disease.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: February 24, 2015
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Howard Weiner, Eugene Ponomarev, Tatyana Veremeyko, Anna M. Krichevsky
  • Diagnosing and Monitoring CNS Malignancies Using MicroRNA
    Publication number: 20130344063
    Abstract: The use of specific microRNAs (miRNAs) present in CSF as biomarkers for particular brain malignancies and disease activity.
    Type: Application
    Filed: November 16, 2011
    Publication date: December 26, 2013
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Anna M. Krichevsky, Nadiya Teplyuk, Brit Mollenhauer, Santosh Kesari
  • TREATMENT OF INFLAMMATORY DISEASES USING MIR-124
    Publication number: 20120202870
    Abstract: Methods of treating, reducing the risk of developing, or delaying the onset of an inflammatory disease are disclosed. The methods involved providing a subject with or at risk of developing an inflammatory disease and administering to the subject an effective amount of a first therapeutic composition comprising miR-124. Further provided are methods of diagnosing a subject with or at risk of developing an inflammatory disease.
    Type: Application
    Filed: June 25, 2010
    Publication date: August 9, 2012
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Howard Weiner, Eugene Ponomarev, Tatyana Veremeyko, Anna M. Krichevsky